The purpose of the study is try to find out how Iran and Turkey current relations which were effected by Iran nuclear program after changing dynamics in Middle East with Arab Spring. In this context, both countries relation has been examined comparatively in terms of chronological perspective. Iran's nuclear progress caused its image more dangerous and more striking in the international arena. This situation of dilemma makes Iran a threat in Middle East and on the international arena; it produces paradox on Iran for its description as friend or foe. As being a balance fact for Eurasia politics, Turkey is expected as a state to assume role on the Iran’s nuclear practices between the West and Iran. The nuclear deal with Iran on April 2015 will probably prove inexpugnable effect on national power of Iran which will increase Iran’ impact upon on Middle East. After the Arab Spring the political struggle between both countries has been affected by regional changes. The countries relations will apparently be included into understanding of mutual interest politics