Duygu GÖK YURTSEVEN, Zehra MİNBAY, Özhan EYİGÖR

Besin Alımının Kontrolündeki Anoreksijenik Peptit: Nesfatin-1

Enerji homeostazının regülasyonunda yer alan açlık ve tokluğun fizyolojik mekanizması, besin alımını uyarıcı oreksijenik faktörlerle inhibe edici anoreksijenik çoğu faktörün birleşiminden oluşan kompleks bir süreçle düzenlenir. Son on yılda, besin alımı ve enerji harcanmasını değiştiren pek çok nöropeptit tanımlanmıştır. NEFA/Nükleobindin2 prekürsöründen türeyen nesfatin-1 peptiti besin alımını baskılayan hipotalamik nöropeptit olarak karşımıza çıkar. Nesfatin-1 ilk defa hipotalamus ve soliter traktusta (NTS) yerleşik nöronlarda belirlenmiştir. Nesfatin-1 nöronlarının beyin alanlarındaki ekspresyon profilleri, fizyolojik mekanizmalar üzerindeki etkisi ve de diğer nöropeptitlerle olan kolokalizasyonları hala üzerinde çalışılmakta olan konulardandır. Laboratuvarımızda yürütülen çalışmalarda bizde nesfatin-1’in hipotalamik çekirdeklerdeki lokalizasyonunu belirledik. Bu derleme makalede, nesfatin nöronlarının lokalizasyonunun yanı sıra, nesfatin-1 peptitinin fizyolojisi ile fonksiyonlarına ait, bugüne kadar literatürde yer alan bilgilere yer verilmiştir.

Anahtar Kelimeler:

NUCB2, Nesfatin-1, Hipotalamik çekirdekler, Beslenme

Anorexigenic Peptide in the Control of Food Intake: Nesfatin-1

The sensations of hunger and fullness during the regulation of the energy homeostasis are regulated through a complex process. This process consists of many anorexigenic factors’ combination that inhibit food intake as well as appetite-stimulating (orexigenic) factor. In the last decade, many neuropeptides have been identified that alter food intake and energy expenditure. Nesfatin-1 peptide derived from the NEFA/nucleobindin2 precursor have emerged as a hypothalamic neuropeptide suppressing the food intake. Nesfatin-1 was first identified in the hypothalamus and solitary tract neurons (NTS). The expression profiles in the brain areas of NUCB2/Nesfatin-1 neurons, their effect on physiological mechanisms, and their co-localizations with other neuropeptides are topics still studied. In the studies carried out in our laboratory, we also have identified the location of nesfatin-1 in the hypothalamic nuclei. In this review, in addition to the localization of nesfatin neurons, recent literature knowledge on the physiology and functions of nesfatin-1 peptide are included.

Keywords:

NUCB2, Nesfatin-1, Hypothalamic nuclei, Feeding,

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