Mikst gliomlar

Tanısal ölçütleri zor olmakla birlikte, mikst gliomlar iki farklı hücreden oluşan tümörlerdir. Mikst gliom tanısı için, iki birbirinden farklı morfolojik özellik gösteren alanın birlikte bulunması ön koşuldur. Birçok astrositomada oligodendrogliomayı anımsatan alanlar bulunabildiği gibi tersi de geçerlidir. Bunlara karşın, bir tümörde böylesi bir karşımın bulunması ona mikst gliom tanısı için yeterli değildir. Bu tümörlere tanısal nöropatolojinin günlük uygulamasında nadiren rastlanır. En sık oligoastrositoma şeklindeki mikst gliomaya rastlanmasına karşın, kuramsal olarak oligoastrositoma, ependimoastrositoma, ve oligoependimoma şeklindeki kombinasyonları olabilir

Anahtar Kelimeler:

Mikst glioma, oligoastrositoma, patoloji, oligoastrositoma, oligoependimoma, ependimoastrositoma, hidrid tümör

Mixed gliomas

Mixed gliomas are composed of two types of neoplastic glia, but the diagnostic criteria are difficult to define. A diagnosis of mixed glioma should be reserved for neoplasms with separate regions of morphologically distinct cells. Many astrocytomas contain a few cells reminiscent of those in oligodenderoglioma and vice-versa, but such an admixture does not qualify for the term of mixed glioma. Although they are rare tumors in daily practice of diagnostic neuropathology, theoretic combinations of oligoastrocytoma, ependymoastrocytoma, and oligoependymoma, the oligoastrocytoma clearly predominates

Keywords:

Mixed glioma, oligoastrocytoma, pathology, oligoastrocytoma, oligoependymoma, ependymoastrocytoma, hybrid tumor,

PDF

___

Kleihues P, Cavenee WK. Pathology and Genetics of Tumours of the Nervous System. World Health Orga- nization Classification of Tumours. International Agency for Research on Cancer (IARC). IARC Pres, Lyon, 2000; 55- de la Monte SM. Uniform lineage of oligodendrogliomas. Am J Pathol 1989; 135: 529-40.
Hart MN, Petito CK, Earle KM. Mixed gliomas. Cancer 1974; 33: 134-40.
Scherer HJ. Cerebral astrocytomas and their derivatives. Am J Cancer 1940; 40: 159-198.
Parisi JE, Scheithauer BW. Glial Tumors. In: Nelson JS, Parisi JE, Schochet SS (editors). Principles and Practice of Neuropathology. First ed., Mosby-Year Book, Inc., 1993; 153-1
David Schiffer. Oligodendroglioma. In: David Schiffer (editor). Brain Tumors. Second ed, Springer; 1997; 214- 2
Burger PC, Scheithauer BW. Tumors of Neuroglia and Choroid Plexus Epithelium. In: Burger PC, Scheithauer BW (editors). Atlas of Tumor Pathology. Tumors of the Central Nervous System, third series, fascicle 10, Washington, D.C. Armed Forces Institute of Pathology; 1993; 107-120.
Glass J, Hochberg FH, Gruber ML, Louis DN, Smith D, Rattner B. The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy. J Neurosurg 1992; 76: 741-5.
Kros JM, Van Eden CG, Stefanko SZ, Waayer-Van Batenburg M, Van der Kwast TH. Prognostic implications of glial fibrillary acidic protein containing cell types in oligodendrogliomas. Cancer 1990; 66: 1204-12.
Shaw E, Scheithauer B, O’Fallon J. Astocytomas (A), oligo-astrocytomas (OA), and oligodendrogliomas (O): a comparative survival study. Neurology 1992; 42(Suppl 3): 3
Bonnin JM, Colon LE, Morawetz RB. Focal glial differentia- tion and oncocytic transformation in choroid plexus papilloma. Acta Neuropathol (Berl) 1987; 72: 277-80.
Kawano N, Yada K, Yagishita S. Clear cell ependymoma. A histological variant with diagnostic implications. Virchow’s Arch (A) 1989; 415: 467-72..