Gökçen GÜVENÇ BAYRAM, Burçin ALTINBAŞ, Murat YALÇIN

Merkezi Yolla Enjekte Edilen Histamin ve Reseptör Antagonistlerinin, Sıçanların Yem, Su Alımı ve Vücut Ağırlıkları Üzerine Etkileri

Amaç: Başta hipotalamus olmak üzere merkezi sinir sisteminde geniş bir dağılım gösteren histamin birçok otonomik işlevin düzenlenmesinde bir nörotransmitter veya nöromodülatör olarak rol almaktadır. Hipotalamusta; yiyecek, su alımı ve vücut ağırlığının düzenlenmesinde görev alan birçok çekirdekte histamin reseptörleri geniş bir dağılıma sahiptir. Çalışmada, merkezi yolla histamin, klorfeniramin, ranitidin ve tiyoperamid tedavilerinin sıçanlarda oluşturduğu yiyecek ve su alımı ile vücut ağırlığı değişimleri araştırılmıştır. Gereç ve Yöntemler: Çalışma, Sprague-Dawley ırkı sıçanlarda gerçekleştirilmiştir. Histamin (100 nmol), histaminerjik H1 reseptör antagonisti klorfeniramin (100 nmol), histaminerjik H2 reseptör antagonisti ranitidin (100 nmol) veya histaminerjik H3/H4 reseptör antagonisti tiyoperamid (100 nmol) serebral yan ventriküler yolla günde bir kez olacak şekilde 7 gün boyunca enjekte edilmiştir. Bulgular: Histamin, klorfeniramin ve ranitidinin gıda ve su alımı ile vücut ağırlığında azalmalara neden olmuştur. Fakat tiyoperamid ile yapılan tedavi bahsedilen ilaçların tersine gıda ve su alımı ile vücut ağırlığında artışlara yol açmıştır. Sonuç: Elde edilen veriler, 7 günlük tedaviler sonrasında merkezi histamin, klorfeniramin ve ranitidin tedavilerinin beslenmenin düzenlenmesinde negatif etkilere yol açtığını göstermektedir. Bunun yanında, merkezi tiyoperamid ile yapılan 7 günlük tedavinin gıda ve su alımı ile kilo alımına neden olduğu ortaya çıkmıştır.

Anahtar Kelimeler:

Histamin, Histamin antagonistleri, Gıda alımı, Su alımı, Vücut ağırlığı

Effects of Centrally Injected Histamine and Receptor Antagonists on Feed, Water Intake and Body Weight of Rats

Aim: The histaminergic system, which has a wide distribution in the central nervous system, especially the hypothalamus, plays a role as a neurotransmitter or neuromodulator in the regulation of many autonomic functions. In the hypothalamus, histamine receptors are widely distributed in many nuclei involved in the regulation of food, water intake, and body weight. In this study, food and water intake and body weight changes caused by histamine, chlorpheniramine, ranitidine, and thioperamide treatments chronically in rats were investigated. Materials and Methods: The study was carried out in Sprague-Dawley rats. Histamine (100 nmol), histaminergic H1 receptor antagonist chlorpheniramine (100 nmol), histaminergic H2 receptor antagonist ranitidine (100 nmol), or histaminergic H3/H4 receptor antagonist thioperamide (100 nmol) were injected via the cerebral side ventricular route for 7 days. Results: Histamine, chlorpheniramine, and ranitidine caused reductions in food and water intake and body weight. However, treatment with thioperamide led to increases in food and water intake and body weight, unlike the aforementioned drugs. Conclusion: As a result, the data obtained show that after 7 days of treatments, central histamine, chlorpheniramine, and ranitidine treatments cause negative effects on the regulation of nutrition. In addition, it was revealed that 7 days of treatment with central thioperamide caused weight gain with food and water intake.

Keywords:

Histamine, Histamine antagonists, Eating, Drinking, Body weight,

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