Beray Selver EKLİOĞLU, Mehmet Emre ATABEK, Nesibe AKYÜREK

Tip 1 Diabetes Mellitus'lu Hastaların Uzun Dönem İzlemi: Tek Merkez Deneyimi

Amaç: Tip 1 diyabetes mellitus (DM) çocukluk yaş grubunda sık görülen, pankreasın beta hücrelerinin tahrip olmasısonucu gelişen insülopeni ve hiperglisemi ile karakterize kronik metabolik bir hastalıktır. Çalışmada, Tip 1 DMli hastalarınklinik ve laboratuvar bulgularının değerlendirilmesi ve bulguların literatür eşliğinde tartışılması amaçlanmıştır. Gereç ve Yöntemler: Bu çalışma 2010-2013 Ocak tarihleri arasında Pediatrik Endokrinoloji Kliniğinde takip edilen,Tip 1 DMli 162 hastanın değerlendirildiği tanımlayıcı kesitsel bir araştırmadır. Bulgular: Çalışmamıza 162 hasta dahil edildi (Yaş ortalaması 12.3 ±4.2 yıl). Olguların ortalama diyabet süresi 3.9±2.3 yıl,son 1 yıldaki ortalama Hba1c değerleri%9.74 ± 2.5di. Tip 1 DMye ek olarak olguların % 6.7sinde (n=11) çölyak hasta- lığı , %18.52inde (n=30) de otoimmüntiroid hastalığı mevcuttu. Olguların %9.2sinde (n=15) hipertansiyon, %7. 4ünde(n=12) dislipidemi saptandı. Mikrovasküler komplikasyon olarak % 6.1inde (n=10) 24 saatlik idrarda mikroalbüminüri,%15.4ünde (n=25) EMGde sinir ileti hızında yavaşlama tespit edildi. Sonuç: Tip 1 DMli hastaların izleminde eşlik edebilecek otoimmün hastaların tespiti ve diyabete bağlı gelişebilecekkomplikasyonların erken dönemde saptanması ve koruyucu önlemlerin alınması hastaların hayat kalitesinin arttırılmasıaçısından önemlidir.

Long Term Monitoring of Patients with Type 1 Diabetes Mellitus:A Single Center Experience

Objective: Type 1 diabetes mellitus (DM) is a chronic metabolic disease of childhood characterized by insulin insufficiencyand hyperglycemia due to the destruction of the beta cells of the pancreas. The aim of this study was to determinethe laboratory and clinical characteristics of patients with type 1 diabetes mellitus and to compare the findings with theliterature. Material and Methods: This is a descriptive study of 162 patients with type 1 diabetes mellitus followed by thePediatric Endocrinology department between January 2010 and 2013. results: A total of 162 patients were included in this study (mean age, 12. 3 ±4. 2 years). The mean duration ofdiabetes was 3.89 ± 2.3 years and mean HbA1c was 2.5 ± 9.74%. In addition to Type 1 DM, 6.7% of cases (n = 11)had celiac disease and 18.52% of the cases (n = 30) had autoimmune thyroid disease. Hypertension was present in9.2% of the cases (n = 15) while 7.4% (n = 12) had dyslipidemia. We found had 24-hour urine microalbuminuria in 6.1%of the cases (n = 10) and decreased EMG nerve conduction velocity in 15.4% of the cases (n =25). conclusion: It is important to detect any concurrent autoimmune disorders and diabetes-related potential complicationsin the early stages and to take preventive measures to increase the quality of life during follow-up of patients with Type 1DM.

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