Klinefelter Sendromlu Bir Olguda Trombositoz

Klinefelter Sendromu (KS), erkek karyotipinde (46,XY), fazladan en az bir X kromozomunun bulunması sonucu ortaya çıkan klinik bir tablodur. Klinefelter sendromlu olgularda arteriyel ve venöz tromboembolizm sıklığı yüksek olarak bildirilmekle birlikte tromboembolizm gelişmesine etki eden değişkenler ayrıntılı ve tutarlı olarak tanımlanmamıştır. Bu yazıda trombositozu olan Klinefelter sendromlu (47,XXY) bir olgu sunulmuştur. Olgunun 3 aylık olduğu dönemde, üst solunum yolu enfeksiyonu sırasında trombosit sayısı 900x109 /L olarak bulunmuştur. Olgunun bir yıllık izleminde trombosit sayısı enfeksiyon olmayan dönemlerde de normal değerlerin üzerinde saptanmıştır. Bu nedenle trombositozun Klinefelter sendromlu olgularda tromboembolik olayların etyolojisindeki faktörlerden birisi olabileceğinden, tromboembolizmin engellenmesine yönelik olarak trombositoz dikkate alınmalıdır.

Anahtar Kelimeler:

Klinefelter sendromu, trombositoz

THROMBOCYTOSIS IN A PATIENT WITH KLINEFELTER SYNDROMES

Klinefelter syndrome is caused by an additional X chromosome in male karyotype (46, XY). Arterial and venous thromboses are commonly seen in subjects with Klinefelter syndrome. The etiological parameters of thrombosis have not been defi ned in detail in subjects with Klinefelter syndrome. In this report we present a patient with Klinefelter syndrome (47, XXY) who had thrombocytosis. His thrombocyte count was 900x109/L when he was 3 months old and suffered from an upper respiratory tract infection. His trombocyte count has remained over 350x109/L in one year follow up even when there is no infection. In Klinefelter syndromes, thrombocytosis should be evaluated in order to prevent thrombotic disorders

Keywords:

Klinefelter syndrome, thrombocytosis,

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