Çocuklarda Ağır Astım, Biyolojik Tedaviler ve Covid-19 Pandemisinde Güncel Yaklaşımlar

Astım, çocukluk çağında gözlenen en sık kronik hastalıktır. Ağır astım, çocuklarda daha nadir görülen bir durumdur. Ağır astımda farklı mekanizmalar rol oynadığı için farklı fenotipler söz konusu olup tedavi hastaya göre kişiselleştirilmelidir. Hastanın ağır astım fenotipine katkıda bulunan faktörlerin değerlendirilmesi sonucunda, tip 2 astım olduğu belirlenen hastalara biyolojik tedavilerin uygulaması günümüzde ağır astım tedavisi yönetiminde önemli bir gelişme sağlamıştır. COVID-19 pandemisi sırasında güncel rehberler, biyolojik ajan uygunluk kriterlerini karşılayan ve bu tedavilerin etkili olduğu hastalarda biyolojik tedavilerin uygulanmasına devam edilmesini önermektedir. Aktif SARS-CoV-2 enfeksiyonu durumunda klinik düzelme sağlanana kadar biyolojik tedavi durdurulmalıdır.

Anahtar Kelimeler:

ağır astım, biyolojikler, ÇOCUK, COVID-19

Severe Asthma, Bıological Treatments in Chıldren And Current Approaches In the COVID-19 Pandemic

Asthma is the most common chronic disease observed in children. Severe asthma is a relatively rare condition in children. As different mechanisms play role in severe asthma, there are different phenotypes and treatment should be individualized. The utilization of biological treatments to patients identified to have type 2 asthma, according to the evaluation of the factors that contribute to the patient’s asthma phenotype, has led to a significant improvement in the management of severe asthma treatment today. During the COVID-19 pandemic, current guidelines recommend continuing the biological treatments to the patients meeting biological agent usage criteria and to whom these treatments are effective. In case of active SARS‐CoV‐2 infection, biological therapy should be stopped until clinical improvement is achieved.

Keywords:

severe asthma, biologicals, child, COVID-19,

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