Mehmet AKIN, Işık Yasemin BALCI, Ayhan ACUN

Beta-talasemi majör hastalarında plasma vitamin BI2 ve folik asit düzeyleri

Giriş ve Amaç: Folik asit eksikliği, homozigot beta-talasemi hastalarında bilinen bir durumdur. Etkili olma- yan eritropoezis nedeni ile sürekli transfüzyon yapılan beta-talasemi hastaları daha fazla folik aside ihtiyaç duyarlar. Buna karşın, talasemi hastalarında vitamin B12 eksikliği daha nadir görülmektedir. Talasemi ma- jorde görülen mikrositoz, folik asit ve vitamin B12 eksikliğinin hematolojik bulgularını maskeleyebilir. Bu çalışmada beta-talasemi majör hastalarında vitamin B12 ve folik asit seviyelerini araştırmayı amaçladık. Yöntem: Talasemi major tanısı ile izlediğimiz 92 hastanın vitamin B12 ve folik asit düzeyi ölçüldü. Hiçbir hastaya son 1 yıl içinde vitamin B12 ve/veya folik asit verilmemişti. Sonuçlar: Talasemi major hastalarında vitamin B12, folik asit, vitamin B12 ve folik asit eksikliği birlikteliği sırası ile %13, %9.8, %2.2 oranında saptanmıştır. Sonuç: Ortalama eritrosit hacmi (MCV), talasemi major hastalarında vitamin B12 ve folik asit eksikliğini göstermede iyi bir parametre olmadığı düşünülmektedir.Talasemi major hastalarında vitamin B12 ve folik asit seviyelerinin belirli aralıklar ile ölçülmesini önermekteyiz.

Plasma vitamin B12 and folic acid levels in patients with beta-thalassemia majör

Objective: Homozygous beta thalassemia patients are known to have folic acid defciency. Undertransfused patients with beta-thalassemia major may need more folic acid as they continue to have ineffective erytro- poesis.In contrast, vitamin B12 defciency is rare in patients with beta-thalassemia major. Inthalassemic patients, microcytosis may mask the hematological fnding of macrocytosis seen in folic acid and Vitamin B12 defciecy. In this study, we investigated the levels of vitamin B12 and folic acid in patients with beta thalassemia major. Method: Plasma vitamin B12 and folic acid levels were determined in 92 thalassemia major patients. None had received folic acid and/or vitamin B12 supplementation in the last year. Results: We found that 13%, 9.8%, and 2.2% of thalassemic patients have in vitamin B12, folic acid, and both vitamin B12 and folic acid defciency, respectively. Conclusion: Mean corpuscular volume (MCV) is not a good marker of folic acid ve vitamin B12 defciency in talasemia major patients. We recommend that vitamin B12 and folic acidlevelsofthalassemia major patients should be measured periodically.

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