This mixed research aims to design and implement the Web Application on Bayes’ Theorem (WABT) in the Statistical Instrumentation for Business subject. WABT presents the procedure to calculate the probability of Bayes’ Theorem through the simulation of data about the supply of products. Technology Acceptance Model (TAM), machine learning and data science are used to analyze the impact of WABT on the educational process. The results of machine learning (60%, 70% and 80% of training) indicate that WABT positively influences the Motivation, Autonomy, Personalized learning and Active role. Data science identifies predictive models of the impact of WABT on the teaching and learning process through the decision tree technique. In addition, WABT is a pleasant, simple, useful and innovative web tool for the educational field. Finally, teachers can use TAM model, data science and machine learning in order to identify the impact of digital tools on the educational process.