Mustafa Ömer İZZETTİNOĞLU, Fatih Erkan AKAY, Rüveyde GARİP

CLINICAL AND HISTOPATHOLOGICAL EVALUATION OF EYELID LESIONS: RETROSPECTIVE ANALYSIS OF TERTIARY MEDICAL CENTER REFERRALS

Aims: To clinically and histopathologically examine eyelid lesions and evaluate the consistency of clinical examination by comparing the provisional diagnoses of patients with their postoperative histopathology results. Methods: In this study, the records of 408 patients who applied to Trakya University, Department of Ophthalmology with an eyelid mass and underwent surgery between January 2000 to November 2019 were retrospectively analyzed. Patients’ data comprised age, gender, location of the mass, lesion distribution according to age and gender, provisional clinical diagnosis of the patients, and histopathological reports. Results: Out of 408 patients, 220 (54%) were female, and 188 (46%) were male. The mean age of the patients was 46.9 ± 20.17 years (range; 5-90 years). In the histopathological examination of the lesions, 318 (77.9%) of them were benign, and 90 (22.1%) of them were malignant. The most common benign lesion was chalazion [112 (35.2%)], while the most common malignant lesion was basal cell carcinoma [71 (78.9%)]. The clinical pre-diagnosis and histopathological di- agnosis were found to be compatible in 81 (90%) patients with a malignant lesion. There was a statistically significant difference in age between malignant and benign lesions, where malignant lesions were found more in older patients. The histopathological examination ended up being malignant in 2.2% of the lesions with a benign provisional diagnosis. Conclusion: In conclusion, even though most common eyelid lesions in our study were found to be benign, some lesions diagnosed as benign in clinic were found to be malignant after histopathological examination. Hence all excisions should be evaluated histopathologically to achieve a better clinical outcome in all patients with an eyelid lesion.

Keywords:

Eyelid lesion, basal cell carcinoma, chalazion,

PDF

___

1. Gundogan FC, Yolcu U, Tas A et al. Eyelid tumors: clinical data from an eye center in Ankara, Turkey. Asian Pac J Cancer Prev 2015;16(10):4265-9.
2. Al-Faky YH. Epidemiology of benign eyelid lesions in patients presenting to a teaching hospital. Saudi J Ophthalmol 2012;26(2):211-6.
3. Hussain I, Khan FM, Alam M et al. Clinicopathological analysis of malignant eyelid tumours in north-west Pakistan. J Pak Med Assoc 2013;63(1):25-7.
4. Huang YY, Liang WY, Tsai CC et al. Comparison of the clinical characteristics and outcome of benign and malignant eyelid tumors: an analysis of 4521 eyelid tumors in a tertiary medical center. Biomed Res Int 2015;2015:453091.
5. Karabulut HH, Karabulut YY, Şenel E et al. Göz kapağı tümörlerinin histopatolo- jik ve demografik özellikleri. Turk J Dermatol 2014;4:197-201.
6. Bagheri A, Tavakoli M, Kanaani A et al. Eyelid masses: a 10-year survey from a tertiary eye hospital in Tehran. Middle East Afr J Ophthalmol 2013;20(3):187-92.
7. Uzlu D, Akyol N, Ercin ME et al. Kliniğimizde cerrahi olarak tedavi edilen göz kapağı tümörlerinin histopatolojik bulguları. Dicle Tip Derg 2020;47:146-53.
8. Coroi MC, Roşca E, Muţiu G et al. Eyelid tumors: histopathological and clinical study performed in County Hospital of Oradea between 2000-2007. Rom J Mor- phol Embryol 2010;51(1):111-5.
9. Keçeci Y, Taşlı FA, Sır E et al. Göz kapağı tümörlerinin insidansı. Turk J Plast Surg 2013;21(2):20-3.
10. Ho M, Liu DTL, Chong KKL et al. Eyelid tumours and pseudotumours in Hong Kong: a ten-year experience. Hong Kong Med J 2013;19(2):150-5.
11. Kumar R. Clinicopathologic study of malignant eyelid tumours. Clin Exp Optom 2010;93(4):224-7.
12. Jahagirdar SS, Thakre TP, Kale SM et al. A clinicopathological study of eyelid ma- lignancies from central India. Indian J Ophthalmol 2007;55(2):109-12.
13. Kaliki S, Bothra N, Bejjanki KM et al. Malignant eyelid tumors in India: a study of 536 Asian Indian patients. Ocul Oncol Pathol 2019;5:210-9.
14. Kurt A, Mutlu S, Yener H et al. Primer göz kapağı tümörlerinde histopatoloji sonuçları. Dicle Tıp Derg 2015;42(1):72-7.
15. Kersten RC, Ewing-Chow D, Kulwin DR et al. Accuracy of clinical diagnosis of cutaneous eyelid lesions. Ophthalmology 1997;104(3):479-84.