Malignant fibrous histiocytoma (giant cell type) of soft parts in the abdominal mammary region of a female Ankara (Angora) cat
The present report describes a giant cell type of malignant fibrous histiocytoma (MFH), diagnosed in soft parts of the right abdominal mammary region, in an 11-year old, 8 kg, nulliparous female Ankara (Angora) cat diagnosed in soft parts of the right abdominal mammary region. The tumor, surgically excised from the abdominal region, had a flexible consistency with ulcerated overlying skin. The tumor was elliptical (8.0 cm × 7.0 cm × 5.0 cm) with a necrotic area of 3.0 cm × 1.5 cm × 1.0 cm in the middle of the cut surface. Microscopically, the tumor was subcutaneous and unencapsulated. Tumor cells were comprised of a mixture of fibroblast-like spindle and histiocytic-like cells with a pale pink cytoplasm. Cells were oval or elongated with a round, large nucleus, and small single nucleoli. In addition, an abundant number of multi-nucleated giant cells were observed. In some fields, there was a dense collagen connective tissue, foci of cartilaginous, bony metaplasia, and hemorrhage surrounding necrosis.
Malignant fibrous histiocytoma (giant cell type) of soft parts in the abdominal mammary region of a female Ankara (Angora) cat
The present report describes a giant cell type of malignant fibrous histiocytoma (MFH), diagnosed in soft parts of the right abdominal mammary region, in an 11-year old, 8 kg, nulliparous female Ankara (Angora) cat diagnosed in soft parts of the right abdominal mammary region. The tumor, surgically excised from the abdominal region, had a flexible consistency with ulcerated overlying skin. The tumor was elliptical (8.0 cm × 7.0 cm × 5.0 cm) with a necrotic area of 3.0 cm × 1.5 cm × 1.0 cm in the middle of the cut surface. Microscopically, the tumor was subcutaneous and unencapsulated. Tumor cells were comprised of a mixture of fibroblast-like spindle and histiocytic-like cells with a pale pink cytoplasm. Cells were oval or elongated with a round, large nucleus, and small single nucleoli. In addition, an abundant number of multi-nucleated giant cells were observed. In some fields, there was a dense collagen connective tissue, foci of cartilaginous, bony metaplasia, and hemorrhage surrounding necrosis.
___
- Ford, G.H., Empson, R.N. Jr., Plopper, C.G., Brown, P.H.: Giant cell tumor of soft parts. A report of an equine and a feline case. Vet. Pathol., 1975; 12: 428-433.
- Gibson, K.L, Blass, C.E., Simpson, M., Gaunt, S.D.: Malignant fibrous histiocytoma in a cat. J. Am. Vet. Med. Assoc., 1989; 194: 1443-1445.
- Gleiser, C.A., Raulston, G.L., Jardine, J.H., Gray, K.N.: Malignant fibrous histiocytoma in dogs and cats. Vet. Pathol., 1979; 16: 199-208.
- Garma-Aviña, A.: Milgnant fibrous histiocytoma of the giant cell type in a cat. J. Comp. Pathol., 1987; 97: 551-557.
- Boneschi, V., Parafioriti, A., Armiraglio, E., Gaiani, F., Brambilla, L.: Primary giant cell tumor of soft tissue of the groin – a case of 46 years duration. J. Cutan. Pathol., 2009; 36 (Suppl. 1): 20-24.
- Kıran, M.M., Karaman, M., Hatipoğlu, F., Koç, Y.: Malignant fibrous histiocytoma in a dog: a case report. Vet. Med. Czech, 2005; 50: 553–557.
- Oda, Y., Tamiya, S., Oshiro, Y., Hachitanda, Y., Kinukawa, N., Iwamoto, Y., Tsuneyoshi, M.: Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts. Pathol. Int., 2002; 52: 595–606.
- Ichikawa, K., Tanino, R.: Soft tissue giant cell tumor of low malignant potential. Tokai J. Exp. Clin. Med., 2004; 29: 91-95.
- Haziroğlu, R., Kul, O., Tunca, R., Güvenç, T.: Osteoclast-like giant cell tumour arising from the kidney in a dog. Acta Vet. Hung., 2005; 53: 225-230.
- Pires, M.A.: Malignant fibrous histiocytoma in a puppy. Vet. Rec., 1997; 140: 234-235.
- Morris, J.S., McInnes, E.F., Bostock, D.E., Hoather, T.M., Dobson, J.M.: Immunohistochemical and histopathologic features of 14 malignant fibrous histiocytomas from flat-coated retrievers. Vet. Pathol., 2002; 39: 473–479.
- Wobeser, B.K., Kidney, B.A., Powers, B.E., Withrow, S.J., Mayer, M.N., Spinato, M.T., Allen, A.L.: Diagnoses and clinical outcomes associated with surgically amputated feline digits submitted to multiple veterinary diagnostic laboratories. Vet. Pathol., 2007; 44: 362–365.
- Doddy, F.D., Glickman, L.T., Glickman, N.W., Janovitz, E.B.: Feline fibrosarcomas at vaccination sites and non-vaccination sites. J. Comp. Pathol., 1996; 114: 165-174.
- Tuluc, M., Zhang, X., Inniss, S.: Giant cell tumor of the nasal cavity: case report. Eur. Arch. Otorhinolaryngol., 2007; 264: 205–208.
- Guo, H., Garcia, R.A., Perle, M.A., Amodio, J., Greco, M.A.: Giant cell tumor of soft tissue with pulmonary metastases: pathologic and cytogenetic study. Pediatr. Dev. Pathol., 2005; 8: 718–724.