Köpeklerde deneysel akut etilen glikol toksikasyonunun 4-metil pirazol ve etanol ile tedavisi

Bu çalışmada, Antifiriz (AF) verilen 30 adet köpek üzerinde Etanol ve 4-Metil Pirazol'ün (4-MP) tedavideki etkileri araştırıldı. Antifıriz toksikasyonu; serum üre, kreatinin ve potasyum düzeylerinde önemli artışlar, kalsiyum düzeyinde ise azalmaya neden oldu. Bu toksikasyon için patognomik olan Ca-okzalat monohidrat kristalleri de idrar sedimentinde önemli oranda görüldü. Köpeklerde AF toksikasyonunda şekillenen multisistemik etkiler üzerinde ve Alkol Dehidrojenaz enziminin inhibisyonunda Etanol kısmen etkili oldu. Etanol verildikten sonra MSS bulguları da gözlendi. Bu sonuçlara göre 4-Metil Pirazol ile daha erken ve güvenli bir iyileşme dikkati çekti. Kanın metabolik parametreleri ile idrar bulgularının çok fazla değişmemesi ve nekropsi bulgularındaki önemli değişiklikler nedeniyle 4-MP+NaHC03 tedavisinin Etanol+NaHC03 tedavisinden daha etkili olduğuna karar verildi.

The treatment of experimental acute ethylene glycol (Anifreeze) toxication using 4-methyl pyrazol and ethanol in dogs

The effects of ethanol and 4-methyl pyrazole were investigated in the treatment of 30 dogs toxicated with antifreeze (AF). The AF toxication produced significant increases in blood urea, creatinin and potassium and a decrease in blood calcium levels. Calcium-oxalate monohydrate, which is pathognomic for AF toxication, was consistently seen in urine sediment. Ethanol was rarely effective on the multisystemic effects that occurred in dogs or ADH inhibition. CNS findings were also observed after ethanol administration. The results indicated that 4-MP treatment provided earlier and safer healing than ethanol. It was deduced that 4-MP + NaHC03 was more effective than ethanol + NaHC03 on AF toxication, based on the metabolic parameters, urine chemistry and necropsy findings.

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