Armağan ÇOLAK, Armağan HAYIRLI, Mehmet CENGİZ, Muhammad Furqan Asghar CHACHER

Investigation of the effect of repeated use of PRIVD on serum progesterone, estrogen levels, and ovulatory follicle diameter in pubertal heifers

The purpose of this study was to evaluate the effect of reuse of progesterone-releasing intravaginal devices (PRIVDs) onserum progesterone, estrogen levels, and ovulatory follicle diameter in pubertal heifers. Three pubertal Holstein heifers were used inthe study for three different periods with the usage of three PRIVDs up to three times from day 0 to 7 according to the Latin squaremodel. Blood samples were collected on days 0, 3, 5, 7, and 9 for hormonal analysis. Ovulatory follicle diameter was measured bytransrectal ultrasonography 60 h after removal of the PRIVD. Serum progesterone demonstrated a significant relationship with deviceuse and day (P < 0.01) with the 1st use group showing the highest mean serum progesterone levels. Mean serum progesterone levelsof the 2nd and 3rd use did not show any significant difference among them. The peak level of mean serum progesterone was recordedon day 3 of the study, whereas minimum levels were seen at days 0 and 9. Serum progesterone concentrations of days 5 and 7 had nosignificant differences among them. The interaction between use of PRIVDs and days interval was significant (P < 0.01). Serum estrogenconcentration (P > 0.05) and ovulatory follicle diameter (P > 0.05) did not differ significantly with the use of the PRIVD at day 9. Inthe present study, even the 3rd use of the PRIVD produced similar results as the first use. In conclusion, PRIVDs can be reused ormanufactured with low progesterone for heifers to reduce hormonal synchronization cost.

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1. Aali M, Pretheeban T, Giritharan G, Rajamahendran R. Pregnancy rates and peripheral progesterone levels following Ovsynch or CIDR ovulation synchronization/timed artificial insemination protocols in postpartum dairy cows. Can J Anim Sci 2008; 88: 457-461.
2. Lima F, De Vries A, Risco C, Santos J, Thatcher W. Economic comparison of natural service and timed artificial insemination breeding programs in dairy cattle. J Dairy Sci 2010; 93: 4404- 4413.
3. Revah I, Butler W. Prolonged dominance of follicles and reduced viability of bovine oocytes. J Reprod Fertil 1996; 106: 39-47.
4. Colazo MG, Kastelic JP, Davis H, Rutledge MD, Martinez MF, Small JA, Mapletoft RJ. Effects of plasma progesterone concentrations on LH release and ovulation in beef cattle given GnRH. Domest Anim Endocrinol 2008; 34: 109-117.
5. Zuluaga JF, Williams GL. High-pressure steam sterilization of previously used CIDR inserts enhances the magnitude of the acute increase in circulating progesterone after insertion in cows. Anim Reprod Sci 2008; 107: 30-35.
6. Brann DW, Chorich LP, Mahesh VB. Effect of progesterone on galanin mRNA levels in the hypothalamus and the pituitary: correlation with the gonadotropin surge. Neuroendocrinology 1993; 58: 531-538.
7. Abdallah H, El Rahim AA. Efficiency of previously used CIDR stored for a prolonged period. Adv Anim Vet Sci 2014; 2: 508- 515.
8. Júnior IC, Sá Filho O, Peres R, Aono F, Day M, Vasconcelos JLM. Reproductive performance of prepubertal Bos indicus heifers after progesterone-based treatments. Theriogenology 2010; 74: 903-911.
9. Vale W, Melo P, Walter E, Ribeiro H, Rolim-Filho S, Reis A, Sousa J, Silva A. Fixed timed artificial insemination (FTAI) through the progesterone (CIDR) of 1st, 2nd, 3rd and 4th uses in bovine. I. Conception rate related to reproductive category, related to body condition scoring (BCS), related to calf withdrawal and use of eCG. Livestock Res Rural Dev 2011; 23: 1-10.
10. Muth-Spurlock A, Poole D, Whisnant C. Comparison of pregnancy rates in beef cattle after a fixed-time AI with once-or twice-used controlled internal drug release devices. Theriogenology 2016; 85: 447-451.
11. Dias F, Colazo M, Kastelic J, Mapletoft R, Adams G, Singh J. Progesterone concentration, estradiol pretreatment, and dose of gonadotropin-releasing hormone affect gonadotropinreleasing hormone-mediated luteinizing hormone release in beef heifers. Domest Anim Endocrinol 2010; 39: 155-162.
12. Dadarwal D, Mapletoft R, Adams G, Pfeifer L, Creelman C, Singh J. Effect of progesterone concentration and duration of proestrus on fertility in beef cattle after fixed-time artificial insemination. Theriogenology 2013; 79: 859-866.
13. Dahlen C, Klein S, Lamb G, Mercadante V, Steichen P. Physiological response of beef heifers after receiving a reused controlled internal drug release insert processed with different heat-treating methods. J Anim Sci 2014; 92: 2275-2279.
14. Martínez M, Kastelic J, Colazo M, Mapletoft R. Effects of estradiol on gonadotrophin release, estrus and ovulation in CIDR-treated beef cattle. Domest Anim Endocrinol 2007; 33: 77-90.
15. Colazo M, Kastelic J, Small J, Mapletoft R. Follicle dynamics, estrus and ovulation in CIDR-treated cows given ECP, GnRH, or progesterone during diestrus, International congress on animal reproduction 2014; pp. 330.
16. Savio J, Thatcher W, Morris G, Entwistle K, Drost M, Mattiacci M. Effects of induction of low plasma progesterone concentrations with a progesterone-releasing intravaginal device on follicular turnover and fertility in cattle. J Reprod Fertil 1993; 98: 77-84.
17. Whittaker P, Colazo M, Martínez M, Kastelic J, Mapletoft R. New or used CIDR-B devices and estradiol benzoate, with or without progesterone, for fixed-time AI in beef cattle. Theriogenology 2002; 57: 391.
18. Cerri RL, Rutigliano HM, Bruno R, Santos JE. Progesterone concentration, follicular development and induction of cyclicity in dairy cows receiving intravaginal progesterone inserts. Anim Reprod Sci 2009; 110: 56-70.
19. El-Tarabany MS. The efficiency of new CIDR and onceused CIDR to synchronize ovulation in primiparous and multiparous Holstein cows. Anim Reprod Sci 2016; 173: 29-34.
20. Esterman R, Austin B, Woodall S, McKinniss E, Yelich J. Effects of day of cycle at initiation of a Select Synch/CIDR+ TAI protocol in suckled Angus (AN) and Brangus (BN) cows. J Anim Sci 2008; 86: 65.
21. Eslami M, Bolourchi M, Seifi HA, Asadi F, Akbari R. Treatment of clinical endometritis in dairy cows by previously used controlled internal drug release devices. Theriogenology 2015; 84: 437-445.
22. Naseer Z, Ahmad E, Singh J, Ahmad N. Fertility Following CIDR Based Synchronization Regimens in Anoestrous Nili‐ Ravi Buffaloes. Reprod Domest Anim 2011; 46: 814-817.
23. López-Helguera I, López-Gatius F, Garcia-Ispierto I, Serrano- Perez B, Colazo MG. Effect of PRID-Delta devices associated with shortened estrus synchronization protocols on estrous response and fertility in dairy cows. Ann Anim Sci 2017; 17: 757-770.
24. Mingoti RD, de Freitas BG, Ramos RS, Bastos MR, Teixeira AA, Rezende MLG, de Castro MW, Faquim A, Sá Filho MF, Baruselli PS. Pregnancy rate to TAI Nelore (Bos indicus) protocol submitted to 3 or 4 managements using Sincrogest® or CIDR® new and reused. Anim Reprod 2016; 13: 415-415.
25. Colazo M, Kastelic J, Whittaker P, Gavaga Q, Wilde R, Mapletoft R. Fertility in beef cattle given a new or previously used CIDR insert and estradiol, with or without progesterone. Anim Reprod Sci 2004; 81: 25-34.
26. Chacher MFA, Çolak A, Hayırlı A. Efficacy of repeatedly used CIDR device in cattle reproduction: a metaanalysis review of progesterone concentration and conception rate. Turk J Vet Anim Sci 2017; 41: 692-697.
27. Bó G, Baruselli P, Martınez M. Pattern and manipulation of follicular development in Bos indicus cattle. Anim Reprod Sci 2003; 78: 307-326.
28. Rathbone MJ, Bunt CR, Ogle CR, Burggraaf S, Macmillan KL, Burke CR, Pickering KL. Reengineering of a commercially available bovine intravaginal insert (CIDR insert) containing progesterone. J Controll Release 2002; 85: 105-115.
29. Van Cleeff J, Lucy MC, Wilcox CJ, Thatcher WW. Plasma and milk progesterone and plasma LH in ovariectomized lactating cows treated with new or used controlled internal drug release devices. Anim Reprod Sci 1992; 27: 91-106.
30. Martinez M, Kastelic J, Adams G, Mapletoft R. The use of a progesterone-releasing device (CIDR-B) or melengestrol acetate with GnRH, LH, or estradiol benzoate for fixed-time AI in beef heifers. J Anim Sci 2002; 80: 1746-1751.
31. Kesler DJ. Review of estrous synchronization systems: CIDR inserts. In: Proceedings of Applied Reproductive Strategies in Beef Cattle; 2002. pp. 47-60.
32. Wiltbank M, Souza A, Giordano J, Nascimento A, Vasconcelos J, Pereira M, Fricke P, Surjus R, Zinsly F, Carvalho P. Positive and negative effects of progesterone during timed AI protocols in lactating dairy cattle. Anim Reprod 2012; 9: 231-241.
33. Denicol A, Lopes G Jr, Mendonça L, Rivera F, Guagnini F, Perez R, Lima J, Bruno R, Santos J, Chebel R. Low progesterone concentration during the development of the first follicular wave reduces pregnancy per insemination of lactating dairy cows. J Dairy Sci 2012; 95: 1794-1806.
34. Bisinotto R, Chebel R, Santos J. Follicular wave of the ovulatory follicle and not cyclic status influences fertility of dairy cows. J Dairy Sci 2010; 93: 3578-3587.
35. Mauer R, Webel S, Brown M. Ovulation control in cattle with progesterone intravaginal device (PRID) and gonadotropin releasing hormone (GnRH). Annales de Biologie Animale Biochimie Biophysique 1975; 15: 291-296.
36. Stumpf T, Day M, Wolfe M, Clutter A, Stotts J, Wolfe P, Kittok R, Kinder J. Effect of estradiol on secretion of luteinizing hormone during the follicular phase of the bovine estrous cycle. Biol Reprod 1989; 41: 91-97.
37. Bergfeld E, Kojima F, Cupp AS, Wehrman M, Peters K, Mariscal V, Sanchez T, Kinder J. Changing dose of progesterone results in sudden changes in frequency of luteinizing hormone pulses and secretion of 17β-estradiol in bovine females. Biol Reprod 1996; 54: 546-553.
38. Mantovani A, Nichi M, Sá Filho M, Ayres H, Vettorato L, Bó G, Baruselli P. Follicular growth and plasma progesterone patterns in Bos indicus x Bos taurus heifers submitted to different PGF2a/progesterone-based synchronization protocols. Anim Reprod 2010; 7: 91-96.
39. Peres R, Júnior IC, Sá Filho O, Nogueira GDP, Vasconcelos JLM. Strategies to improve fertility in Bos indicus postpubertal heifers and nonlactating cows submitted to fixed-time artificial insemination. Theriogenology 2009; 72: 681-689.
40. Adams G, Matteri R, Ginther O. Effect of progesterone on ovarian follicles, emergence of follicular waves and circulating follicle-stimulating hormone in heifers. J Reprod Fertil 1992; 96: 627-640.