İftikhar HUSSAIN, Muhammad Shahid MAHMOOD, Muhammad İmran ARSHAD, Masood AKHTAR, Fazal MAHMOOD, Azhar RAFIQUE

117100

Immune system dysfunction in broiler chickens experimentally inoculated with fowl adenovirus serotype-4 associated with inclusion body hepatitis hydropericardium syndrome

Inclusion body hepatitis-hydropericardium syndrome (IBH-HPS) in broilers is caused by an adenovirus, here referred to as inclusion body hepatitis-hydropericardium syndrome virus (IBH-HPSV). This study describes the immune status of broiler chickens experimentally inoculated with an isolate of fowl adenovirus-4 serotype-1, involved in IBH-HPS in various trials. When compared with the unchallenged controls, IBH-HPSV-inoculated broilers had significantly higher atrophy of the bursa of Fabricius (BF) by up to 2-fold, as well as of the thymus (up to 9-fold) and spleen (up to 1.5-fold) (P < 0.05), with up to 60% mortality. Upon challenge with sheep red blood cells (SRBCs), IBH-HPSV-inoculated birds had from 2- to 3-log lower anti-SRBC antibody titers than the control. Response to phytohemagglutinin-P (PHA-P) was significantly reduced in IBH-HPSV-inoculated birds (P < 0.05) as compared to the control. Results of the studies revealed that the immune status of broilers is compromised significantly during IBH-HPSV infection in terms of lymphoid organ integrity, humoral, and cell-mediated immune responses, respectively. These findings suggest that immune dysfunction could be a contributing factor in the increased mortality of birds affected by IBH-HPS, which renders the birds immunosuppressed for the rest of their lives.

Anahtar Kelimeler:

Key words: Immune system dysfunction, inclusion body hepatitis-hydropericardium syndrome, broilers, immune response, sheep red blood cells, phytohemagglutinin-P

Immune system dysfunction in broiler chickens experimentally inoculated with fowl adenovirus serotype-4 associated with inclusion body hepatitis hydropericardium syndrome

Inclusion body hepatitis-hydropericardium syndrome (IBH-HPS) in broilers is caused by an adenovirus, here referred to as inclusion body hepatitis-hydropericardium syndrome virus (IBH-HPSV). This study describes the immune status of broiler chickens experimentally inoculated with an isolate of fowl adenovirus-4 serotype-1, involved in IBH-HPS in various trials. When compared with the unchallenged controls, IBH-HPSV-inoculated broilers had significantly higher atrophy of the bursa of Fabricius (BF) by up to 2-fold, as well as of the thymus (up to 9-fold) and spleen (up to 1.5-fold) (P < 0.05), with up to 60% mortality. Upon challenge with sheep red blood cells (SRBCs), IBH-HPSV-inoculated birds had from 2- to 3-log lower anti-SRBC antibody titers than the control. Response to phytohemagglutinin-P (PHA-P) was significantly reduced in IBH-HPSV-inoculated birds (P < 0.05) as compared to the control. Results of the studies revealed that the immune status of broilers is compromised significantly during IBH-HPSV infection in terms of lymphoid organ integrity, humoral, and cell-mediated immune responses, respectively. These findings suggest that immune dysfunction could be a contributing factor in the increased mortality of birds affected by IBH-HPS, which renders the birds immunosuppressed for the rest of their lives.

Keywords:

Key words: Immune system dysfunction, inclusion body hepatitis-hydropericardium syndrome, broilers, immune response, sheep red blood cells, phytohemagglutinin-P,

Turkish Journal of Veterinary and Animal Sciences-Cover

ISSN: 1300-0128
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

Arşiv

Sayıdaki Diğer Makaleler

The hair characteristics of Turkish Angora and Van cats

Serkan ERAT, Şevket ARIKAN

Prevalence of Escherichia coli O157 in red meat and meat products determined by VIDAS ECPT and LightCycler PCR

Seran TEMELLİ, Ayşegül EYİGÖR*, Şahsene ANAR

Probiotic properties, sensory qualities, and storage stability of probiotic banana yogurts

Songül ÇAKMAKÇI, Bülent ÇETİN, Tamer TURGUT, Mustafa GÜRSES, Ahmet ERDOĞAN

The effect of pentylenetetrazole-induced seizures on blood-brain barrier integrity in a rat model of preeclampsia

Mutlu KÜÇÜK, Mehmet KAYA, Nurcan ORHAN, Oğuzhan EKİZOĞLU, Erol ARSLAN, Nadir ARICAN, R.candan GÜRSES, İmdat ELMAS, Rivaze KALAYCI, Bülent AHISHALI

The effect of maternal undernutrition on muscle development in the ovine fetus*

Berjan DEMİRTAŞ, Mukaddes ÖZCAN

The detection of classical enterotoxins of Staphylococcus aureus in raw cow milk using the ELISA method

Ebrahim RAHIMI, Hassan MOMMTAZ, Amir SHAKERIAN, Hamid Reza KAVYANI

Assessing the nutritive value of fruit and vegetable residues as ruminant feed

Keyvan KARKOODI, Hassan FAZAELI, S. Sadegh MIRGHAFFARI

The influence of egg shell crack types on hatchability and chick quality

Mozhdeh Moosanezhad KHABISI, Ahmad SALAHI, Seyed Naser MOUSAVI

Progesterone concentrations and pregnancy rates of repeat breeder cows following postinsemination PRID and GnRH treatments*

Progesterone concentrations and pregnancy rates of repeat breeder cows following postinsemination PRID and GnRH treatments