Haematological and Coagulation Profiles during Severe Tropical Theileriosis in Cattle

This study was conducted to measure selected haematological parameters in Holstein cattle naturally infected with Theileria annulata. Haematological analysis indicated significant decreases in red blood cell count, haematocrit value, haemoglobin amount, mean corpuscular haemoglobin concentration, and white blood cell, lymphocyte, neutrophil, monocyte, eosinophil, and basophil counts. On the other hand, significant increases were seen in mean corpuscular volume and marked reticulocytosis in infected animals compared to the animals in the control (uninfected) group. In the coagulation profile, activated partial thromboplastin time and prothrombin time were significantly prolonged, and platelet counts were significantly less in the infected group compared to those in the control group. Fibrinogen concentration was slightly higher in the infected group than that in the control group. These observations revealed that T. annulata infection in cattle is associated with marked changes in haematological and coagulation parameters.

Haematological and Coagulation Profiles during Severe Tropical Theileriosis in Cattle

This study was conducted to measure selected haematological parameters in Holstein cattle naturally infected with Theileria annulata. Haematological analysis indicated significant decreases in red blood cell count, haematocrit value, haemoglobin amount, mean corpuscular haemoglobin concentration, and white blood cell, lymphocyte, neutrophil, monocyte, eosinophil, and basophil counts. On the other hand, significant increases were seen in mean corpuscular volume and marked reticulocytosis in infected animals compared to the animals in the control (uninfected) group. In the coagulation profile, activated partial thromboplastin time and prothrombin time were significantly prolonged, and platelet counts were significantly less in the infected group compared to those in the control group. Fibrinogen concentration was slightly higher in the infected group than that in the control group. These observations revealed that T. annulata infection in cattle is associated with marked changes in haematological and coagulation parameters.

___

  • Sayin, F., Dinçer, S., Karaer, Z., Cakmak, A., Inci, A., Yukari, B.A., Eren, H., Vatansever, Z, Nalbantoglu, S.: Studies on the epidemiological of tropical theileriosis (Theileria annulata infection) in cattle in Central Anatolia, Turkey. Trop. Anim. Health Prod., 2003; 35: 521-539. 2.
  • Omer, O.H., El-Malik, K.H., Mahmoud, O.M., Haroun, E.M.,
  • Hawas, A., Sweeney, D., Magzoub, M.: Haematological profiles in
  • pure bred cattle naturally infected with Theileria annulata in Saudi
  • Graham, S.P., Brown, D.J., Vatansever, Z., Waddington, D., Taylor, L.H., Nichani, A.K., Campbell, J.D.M., Adamson, R.E., Glass, E.J., Spooner, R.L.: Proinflammatory cytokine expression by Theileria annulata infected cell lines correlates with the pathology they cause in vivo, Vaccine. 2001; 19: 2932-2944.
  • Stockham, S.L., Kjemtrup, A.M., Conrad, P.A., Schmidt, D.A., Scott, M.A., Robinson, T.W., Tyler, J.W., Johnson, G.C., Carson, C.A., Cuddihee, P.: Theileriosis in a Missouri beef herd caused by Theileria buffeli: case report, herd investigation, ultrastructure, phylogenetic analysis, and experimental transmission. Vet. Pathol., 2000; 37: 11-21.
  • Singh, A., Singh, J., Grewal, A.S., Brar, R.S.: Studies on some blood parameters of crossbred calves with experimental Theileria annulata infections. Vet. Res. Commun., 2001; 25: 289-300.
  • Yagi, Y., Furuuchi, S., Takahashi, H., Koyama, H.: Abnormality of osmotic fragility and morphological disorder of bovine erythrocytes infected with Theileria sergenti. Nippon Juigaku Zasshi, 1989; 51: 389-395.
  • Beniwal, R.K., Sharma, R.D., Nichani, A.K.: Determination of duration of immunity of calves vaccinated with the Theileria annulata schizont cell culture vaccine. Vet. Parasitol., 2000; 90: 25-35.
  • Sandhu, G.S., Grewal, A.S., Singh, A., Kondal, J.K., Singh, J., Brar, R.S.: Haematological and biochemical studies on experimental Theileria annulata infection in crossbred calves. Vet. Res. Commun., 1998; 22: 347-354.
  • Mbassa, G.K., Balemba, O., Maselle, R.M., Mwaga, N.V.: Severe anaemia due to haematopoietic precursor cell destruction in field cases of East Coast Fever in Tanzania. Vet. Parasitol., 1994; 52: 243-256.
  • Dumanlı, N., Kelefltimur, H., Nizamlıoğlu, M.: Theileria annulata ile deneysel olarak enfekte edilmifl danalarda hematolojik arafltırmalar. Doğa Vet. Hayv. Derg., 1987; 11: 108-114.
  • Sina, M., Günay, M.: Theileria annulata attenue ve virulent flizontları ile inokule edilen dalaklı ve dalakları çıkarılmıfl danalarda eritrosit, lökosit, hemoglobin PCV ile kanda total bilirubin ve bakır değerlerinin saptanması üzerinde bir arafltırma, Pendik Vet. Kont. Araflt. Enst. Derg., 1981; 13: 35-39.
  • Uilenberg, G.: Theileria infections other than east coast fever. Curr. Top. Vet. Med. Anim. Sci., 1981; 6: 411-427.
  • Yagi, Y., Thongnoon, P., Shiono, H., Chikayama, Y.: Increase in oxidized proteins in Theileria sergenti-infected erythrocyte membrane. J. Vet. Med. Sci., 2002; 64: 623-625.
  • Clark, I.A., Hunt, N.H., Cowden, W.B.: Oxygen-derived free radicals in the pathogenesis of parasitic disease. Adv. Parasitol., 1986; 25: 1-44.
  • Mehta, H.K., Sisodia, R.S., Misraulia, K.S.: Clinical and haematological observations in experimentally induced cases of bovine tropical theileriosis. Indian J. Anim. Sci., 1988; 58: 584- 587.
  • Can, R.: Theileria annulata (Dschunkowsky et Luhs, 1904)’dan ileri gelen Theileriozis üzerinde klinik patolojik çalıflmalar ve tedavi denemeleri, TÜBİTAK VII. Bilim Kongresi, İstanbul, 1980.
  • Shitakha, V.M., Natulya, V.M., Musoke, A.J., Ramasamy, R., Buscher, G.: Complement activation and fibrinolysis during infection with Theileria parva (East Coast fever) in cattle. Vet. Immunol. Immunopathol., 1983; 4: 361-373.
  • Levi, M., Van der Poll, T., ten Cate, H., van Deventer, S.J.H.: The cytokine-mediated imbalance between coagulant and anticoagulant mechanism in sepsis and endotoxaemia. Eur. J. Clin. Invest., 1997; 27: 3-9.
  • Maxie, M.G., Dolan, T.T., Jura, W.G., Tabel, H., Flowers, M.J.: A comparative study of the disease in cattle caused by Theileria parva or T. lawrencei: II. Hematology, clinical chemistry, coagulation studies and complement. Vet. Parasitol., 1982; 10: 1- 19.
  • Kimento, B.A.: Ultrastructure of blood platelets in cattle with East Coast Fever. Am. J. Vet. Res., 1976; 37: 443-447.
Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK