Effect of low birthweight on serum tyroid hormones, glucose, urea and blood pH in newborn lambs

Bu çalışmada, altı kontrol (doğum ağırlığı a 25 kg) ve yedi düşük doğum ağırlığına sahip (doğum ağırlığı

Yeni doğan kuzularda düşük doğum ağırlığının serum tiroit hormonları, glikoz, üre ve kan pH' sı üzerindeki etkisi

In this study, serum thyroid hormone, glucose and urea levels as well as blood pH values were compared between six control (birthweight a 2.B kg) and seven experimental Merino lambs (birthweight < 2.5 kg, hypotrophic) at 2, 4, 8 and 24 h postpartum. Serum levels of total thyroxin (T4), free thyroxin (FT4), total triiodothyronine (T3; with exception of 24 h postpartum), free triiodothyronine (FT3; with the exception of 4, 8 and 24 h postpartum) and glucose were lower in hypotrophic lambs compared to the controls. However, the serum urea levels of hypotrophic animals were higher than those of the controls. On the other hand, serum T3, FT3 and FT4 levels determined at 4 and 8 h were higher than those at 2 and 24 h postpartum in both groups. A similar case was also observed in the serum T4 levels of hypotrophic lambs. In addition, the serum glucose levels of hypotrophic lambs were higher and the blood pH values of both groups were lower at 2 h postpartum. In conclusion, It was observed that low birthweight affected neonatal thyroid function, serum glucose and urea levels in lambs.

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Slebodzinski, A.B.: Perinatal thyroid activity in farm animals and the roie of iodocompounds in maternal milk. Endocrin. Experimentalis. 1986; 20: 229-246.
Fisher, DA. Dussault, J.H.:' Development of the mammalian thyroid gland. In: Handbook of Physiology. Ed. Geiger, S.R-. Washington, Am. Physiol. Soc.'pp. 21-38, 1975.
Fisher, D.A.,,pussault, J.H., Sack, S., Chapra, IJ.: Ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in man, sheep and rat: Rec. Prog. Horm. Res. 1977; 33: 59-116.
Cabello, C, Levieux, D.: Neonatal changes in the concentrations of thyrotropin, triiodothyronine, thyroxine and cortisol in the plasma of preterm and fullterm lambs. J. Develop. Physiol. 1980; 2: 59-69.
Cabello, G., Levieux, D.: Hormonal status in the newborn lamb (Cortisol, T3, T4). Relationships to the birth weight and the length of gestation: effect of the litter size. Biol. Neonate. 1981; 39: 208-216.
Larsen, P.R., Silva, E.J., Kaplan, M.M.: Relationship between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocrine Rev. 1981; 2: 87-102.
Larsson, M., Pettersson, T., Carlstrom, A.: Thyroid hormone binding in serum of 15 vertebrate species: isolation of thyroid binding globulin and prealbumin analogs. Gen. Comp. Endocrinol. 1985; 58: 360-375.
Davison, T.F., Flack, I.H., Butler, E.J.: The binding of thyroxine and triiodothyronine to plasma proteins in the chicken at. the physiological pH. Res. Vet. Sci. 1978; 25: 280-283.
Rudas, P., Szenci, 0., Pethes, G., Bartyik, J.: Correlation between thyroid hormone level and blood pH in cows and in their offspring. Acta Vet. Hun. 1990; 38: 87-93.
Keçeci, T., Kocabatmaz, M.: Hipotiroidizmin kan üre azotu, total protein, glikoz ve total kolesterol düzeyleri üzerindeki etkisi. Vet. Bil. Derg. 1994; 10: 134-138.
Stamper, D.L., Denver, R.J., Licht, P.: Effects of thyroidal status on metabolism and growth of juvenile turtles, Pseudemys elegans. Comp. Biochem. Physiol., 1990; 96A: 67-73.
Sakaguchi, M., Suzuki, S., Nagashima, K., Shimano, S., Uchida, S., Kuroume, T.: Longitudinal study of free thyroxine in low-birth- weight infants by paper disk method. J. Pediatr. 1983; 103: 793-796.
Wrutniak, C, Cabello, G.: Changes in the concentration of thyroxine in the plasma of rat fetuses during late gestation: influence of ligation of the maternal uterine vein and artery. J. Endocr. 1983; 99: 233-238.
Theriez, M., Tissier, M., Molenat, G., Brelurut, A., Brun, J.P., Dacheux, F.: Productivite comparee de deux troupeaux de brebis Limousines et Romanov x Limousines en conduite intensive. In 27e Reun. Annu. F.E.Z., 1976; 43: 1-6.
Houssin, Y., Brelurut, A.: Mortalite avant sevrage d'agneaux de differents genotypes dans un troupeau en conduite intensive. Bull. Techn. C.R.Z.V. Theix. 1980; 40: 5-12.
Stbrak, V., Macho, L, Skultetyova, M., Michalickova, J.: Thyroid activity in early weaned and suckling infants and their lactating mothers. Endocrinol. Exper. 1978; 12: 103-107.
Koldovsky, 0., Krulick, L, Tenore, A., Jumavan, J., Horowitz, C, Lau, H.: Effect of triiodothyronine injection on levels of triiodothyronine and thyroid-stimulating hormone in sera and milk of lactating rats and in sera of their sucklings; precocious development of jejunal-dissacharidases in the sucklings. Biol. Neonate. 1980:37: 103-108.
Anderson, R.R., Nixon, D.A., Akasha, M.A.: Total and free thyroxine and triiodothyronine in blood serum of mammals. Comp. Biochem. Physiol. 1988; 89A: 401-404.
SPSS: SPSS/PC+V.2.0, Base Manual for IBM PC/XT/AT and PS/2. Marija and Morusis, Chicago, IL, Soil Science Society of America, Inc.,
Wrutniak, C, Cabello, G.: Neonatal changes in plasma cortisol, free and total iodothyronine levels in control and hypotrophic lambs. Reprod. Nutr. Develop. 1987; 27: 945-953.
Wrutniak, C, Cabello, G.: Effects of food restriction on cortisol, TSH and iodothyronine concentrations in the plasma of the newborn lamb. Reprod. Nutr. Develop. 1987; 27: 721-732.
Dussault, J.H., Morissette, J., Laberge, C: Blood thyroxine concentration is lower in low birth-weight infants. Clin. Chem. 1979; 12: 2047-2049.
Brock-Jacobsen, B., Andersen, H.J., Prtersein, B., Dige-Petersein, H., Hummer L.: Serum levels of thyrotropin, thyroxine, and triiodothyronine in fullterm, small for gestational age and preterm newborn babies. Acta Paediatr. Scand. 1977; 66: 681-687.
Houssin, Y., Davicco, M.J.: Influence of birthweight on the digestibility of a milk-replacer in newborn lambs. Ann. Rech. Vet. 1979; 10:419-421.
Alexander, G.: Birth weight of lambs:influence and consequences. In: Size at birth, Amsterdam, CIBA Foundation Symp., Elsevier, pp. 215-246, 1974.
Girard, J., Pintado, E., Ferre, P.: Fuel metabolism in mammalian fetus. Ann. Biol. Anim. Biochim. Biophys. 1979; 19: 181-197.
Cabello, G., Wrutniak, C: Influence of experimental acidosis on the concentrations of thyreostimulin (TSH) and iodothyronines (total T4, free T4, T3) in the plasma of newborn lambs. Reprod. Nutr. Develop. 1989; 29: 509-515.
Cabello, G., Wrutniak, C: Thyroid function in the newborn lamb. Physiological approach of the mechanism inducing the changes in plasma thyroxin, free thyroxin and triiodothyronine concentrations. J. Develop. Physiol. 1990; 13: 25-32.
Keçeci, T.: Koyunlarda ve yeni doğan kuzularında kan pH'sı ve tiroit hormon düzeyleri. Vet. Bil. Derg. 1995; 11: 23-27.