Cholesterol efux from sperm: approaches and applications

Cholesterol efux from sperm: approaches and applications

Following ejaculation, sperm appear morphologically mature, but functionally they are inactive. To attain functional capabilityor capacitation in vivo, sperm must reside in the female reproductive tract for a certain period of time before fertilization. In the femalereproductive tract, cholesterol efux from the sperm plasma membrane is considered vital for the initiation of capacitation. A number ofin vitro studies have used biological and nonphysiological means to understand the phenomenon of cholesterol efux and capacitation.In this review, we present a short overview of the role of cholesterol efux in regulating sperm capacitation using various agents. Thisreview provides insight to researchers designing new procedures for sperm preparation to be used in assisted reproductive technology.

___

  • 1. de Lamirande E, Leclerc P, Gagnon C. Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Mol Hum Reprod 1997; 3: 175–194.
  • 2. Yanagimachi R. Requirements of extracellular calcium ions for various stages of fertilization and fertilization-related phenomena in the hamster. Gamete Res 1982; 5: 323–344.
  • 3. Zhu JJ, Barratt CLR, Cooke ID. Effect of human cervical mucus on human sperm motion and hyperactivation in vitro. Hum Reprod 1992; 7: 1402–1406.
  • 4. Davis BK. Uterine fuid proteins bind sperm cholesterol during capacitation in the rabbit. Experientia 1982; 38: 1063–1064.
  • 5. Wolf DE, Hagopian SS, Ishijima S. Changes in sperm plasma membrane lipid difusibility afer hyperactivation during in vitro capacitation in the mouse. J Cell Biol 1986; 102: 1372– 1377.
  • 6. Benof S, Hurley I, Cooper GW, Mandel FS, Rosenfeld DL, Hershlag A. Head-specifc mannose-ligand receptor expression in human spermatozoa is dependent on capacitation associated membrane cholesterol loss. Hum Reprod 1993; 8: 2141–2154.
  • 7. Fraser LR. Mechanisms regulating capacitation and the acrosome reaction. In: Fenichel P, Parinaud J, editors. Human Sperm Acrosome Reaction. Colloque INSERM no. 236. Paris, France: John Libbey Eurotext Ltd.; 1995. pp. 17–33.
  • 8. Baldi E, Casana R, Falsetti C, Krausz C, Maggi M, Forti G. Intracellular calcium accumulation and responsiveness to progesterone in capacitating human spermatozoa. J Androl 1991; 12: 323–330.
  • 9. Bielfeld PR, Anderson A, Mack SR, De Jonge CJ, Zaneveld LJD. Are capacitation or calcium ion fux required for the human sperm acrosome reaction? Fertil Steril 1994; 62: 1255–1261.
  • 10. Leyton L, Saling P. 95 kd sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Cell 1989; 57: 1123–1130.
  • 11. Davis BK. Interaction of lipids with the plasma membrane of sperm cells. I. Te antifertilization action of cholesterol. Arch Androl 1980; 5: 249–254.
  • 12. Yanagimachi R. Mammalian fertilization. In: Knobil E, Neill JD, editors. Te Physiology of Reproduction. New York, NY, USA: Raven Press; 1994. pp. 189–317.
  • 13. Lin Y, Mahan K, Lathrop WF, Myles DG, Primakof P. A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg. J Cell Biol 1994; 125: 1157–1163.
  • 14. Ehrenwald E, Foote RH, Parks JE. Bovine oviductal fuid components and their potential role in sperm cholesterol efux. Mol Reprod Develop 1990; 25: 195–204.
  • 15. Térien I, Moreau R, Manjunath P. Major proteins of bovine seminal plasma and high-density lipoprotein induce cholesterol efux from epididymal sperm. Biol Reprod 1998; 59: 768–776.
  • 16. Davis BK, Byrne R, Bedigian K. Studies on the mechanism of capacitation: albumin-mediated changes in plasma membrane lipids during in vitro incubation of rat sperm. Proc Natl Acad Sci U S A 1979; 668: 257–266.
  • 17. Davis BK, Byrne R, Bedigan K. Studies on the mechanism of capacitation: albumin mediated changes in plasma membrane lipids during in vitro incubation of rat sperm cells. Proc Natl Acad Sci U S A 1980; 77: 1546–1550.
  • 18. Go KJ, Wolf DP. Albumin-mediated changes in sperm sterol content during capacitation. Biol Reprod 1985; 32: 145–153.
  • 19. Langlais J, Kan FWK, Granger L, Raymond L, Bleau G, Roberts KD. Identifcation of sterol acceptors that stimulate cholesterol efux from human spermatozoa during in vitro capacitation. Gamete Res 1988; 20: 185–201.
  • 20. Yancey PG, Rodrigueza WV, Kilsdonk EP, Stoudt GW, Johnson WJ, Phillips MC, Rothblat GH. Cellular cholesterol efux mediated by cyclodextrins. Demonstration of kinetic pools and mechanism of efux. J Biol Chem 1996; 271: 16026–16034.
  • 21. Térien I, Soubeyrand S, Manjunath P. Major proteins of bovine seminal plasma modulate sperm capacitation by high- density lipoprotein. Biol Reprod 1997; 57: 1080–1088.
  • 22. Tanphaichitr N, Zheng Y, Kates M, Abdullah N, Chan A. Cholesterol and phospholipid levels of washed and Percoll- gradient centrifuged mouse sperm: presence of lipids possessing inhibitory efects on sperm motility. Mol Reprod Develop 1996; 43: 187–195.
  • 23. Furimsky A, Vuong N, Xu H, Kumarathasan P, Xu M, Weerachatyanukul W, Khalil MB, Kates M, Tanphaichitr N. Percoll gradient-centrifuged capacitated mouse sperm have increased fertilizing ability and higher contents of sulfogalactosylglycerolipid and docosahexaenoic acid- containing phosphatidylcholine compared to washed capacitated mouse sperm. Biol Reprod 2005; 72: 574–583.
  • 24. Cincik M, Ergur AR, Tutuncu L, Muhcu M, Kilic M, Balaban B, Urman B. Combination of hypoosmotic swelling/eosin Y test for sperm membrane integrity evaluation: correlations with other sperm parameters to predict ICSI cycles. Arch Androl 2007; 53: 25–28.
  • 25. Crockett EL. Cholesterol function in plasma membranes from ectotherms: membrane-specifc roles in adaptation to temperature. Amer Zool 1998; 38: 291–304.
  • 26. Martinez P, Morros A. Membrane lipid dynamics during human sperm capacitation. Front Biosci 1996; 1: 103–117.
Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

New understanding of an old phenomenon: uncontrolled factors and misconceptions that cast a shadow over studies of the male efect' on reproduction in small ruminants

Trina JORRE DE ST JORRE, Graeme Bruce MARTIN, Penny Alison Rhian HAWKEN

Investigation of the effcacy of Tarantula cubensis extract (Teranekron D6) in the treatment of subclinical and clinical mastitis in dairy cows

Esra CANOOĞLU, Murat ABAY, Kutlay GÜRBULAK, Aytaç AKÇAY, Tayfur BEKYÜREK, Birgit SIST, Simone STEINER, Kadir Semih GÜMÜŞSOY

Antioxidant supplementation and purification of semen for improved artificial insemination in livestock species

Peter PETRUSKA, Marcela CAPCAROVA, Peter SUTOVSKY

Effect of inbreeding on yield and quality of embryos recovered from superovulated Holstein cows

Jiri BEZDICEK, Ludek STADNIK, Alexander MAKAREVICH, Elena KUBOVICOVA, Frantisek LOUDA, Zdenka HEGEDÜSOVA, Radek HOLASEK, Jan BERAN, Michaela NEJDLOVA

Study of insulin-like growth factor 1 effects on bovine type A spermatogonia proliferation and viability

Babak QASEMI PANAHI, Parviz TAJIK, Mansoureh MOVAHEDIN, Gholamali MOGHADDAM, Mohammad Hossein GERANMAYEH

The avian ovary and follicle development: some comparative and practical insights

Alan L. JOHNSON

Application of dietary fish oil in dairy cow reproduction

Anna ZWYRZYKOWSKA, Robert KUPCZYNSKI

New understanding of an old phenomenon: uncontrolled factors and misconceptions that cast a shadow over studies of the ‘male effect’ on reproduction in small ruminants

Trina Jorre De St JORRE, Penny Alison Rhian HAWKEN, Graeme Bruce MARTIN

Expression of vascular endothelial growth factor and hypoxia-inducible factor-1 alpha during the periovulatory period in goats

Chainarong NAVANUKRAW, Jiratti THAMMASIRI, Tossapol MOONMANEE, Jaruk NATTHAKORNKUL

Maternal embryokines that regulate development of the bovine preimplantation embryo

Peter James HANSEN, Anna Carolina DENICOL, Kyle Bradley DOBBS