Hilal ÖZKAN, Nilgün KÖKSAL, Pelin DOĞAN, İpek Güney VARAL, Onur BAĞCI, Taner ÖZGÜR

The effectiveness of serum amyloid A for prediction of neonatal cholestasis associated with parenteral nutrition in premature infants

Parenteral nutrition (PN) has been widely used in premature infants untillenteral feeding can be tolerated. Cholestasis is an important complication ofPN. The objective of this study was to evaluate the role of serial measurementsof serum amyloid A (SAA) during PN and compare its’ effectiveness withC-reactive protein (CRP) and procalcitonin (PCT). We also aimed to determinethe risk factors for PN associated cholestasis (PNAC).Premature infants (

PDF

___

1. Christensen RD, Henry E, Wiedmeier SE, Burnett J, Lambert DK. Identifying patients, on the first day of life, at high-risk of developing parenteral nutritionassociated liver disease. J Perinatol 2007; 27: 284-290.

2. Hsieh MH, Pai W, Tseng HI, Yang SN, Lu CC, Chen HL. Parenteral nutrition-associated cholestasis in prematüre babies: risk factors and predictors. Pediatr Neonatol 2009; 50: 202-207.

3. Klein CJ, Ravenis M, Kusenda C, Scavo L. Parenteral Nutrition–Associated Conjugated Hyperbilirubinemia in Hospitalized Infants. J Am Diet Assoc 2010; 110: 1684-1695.

4. Robinson DT, Ehrenkranz RA. Parenteral nutritionassociated cholestasis in small for gestational age infants. J Pediatr 2008; 152: 59-62.

5. Gura KM, Duggan CP, Collier SB, et al. Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management. Pediatrics 2006; 118: 197-201.

6. Colomb V, Jobert-Giraud A, Lacaille F, Goulet O, Fournet JC, Ricour C. Role of lipid emulsion in cholestasis associated with long-term parenteral nutrition in children. J Parenter Enteral Nutr 2000; 24: 345-350.

7. Kurvinen A, Nissinen MJ, Andersson S, et al. Parenteral plant sterols and intestinal failure-associated liver disease in neonates. J Pediatr Gastroenterol Nutr 2012; 54: 803-811.

8. Cober MP, Teitelbaum DH. Prevention of parenteral nutrition-associated liver disease: lipid minimization. Curr Opin Organ Transplant 2010; 15: 330-333.

9. Kosters A, Karpen SJ. The role of inflammation in cholestasis: clinical and basic aspects. Semin Liver Dis 2010; 30: 186-194.

10. DeMauro SB, Kilpatrick LE, Gerdes JS, Abbasi S. Early inflammatory markers for prediction of cholestasis in very-low-birth-weight nfants. Neonatology 2012; 102: 229-234.

11. Koksal N, Harmancı R, Cetinkaya M, Hacımustafaoğlu M. Role of procalcitonin and CRP in diagnosis and follow-up of neonatal sepsis. Turk J Pediatr 2007; 49: 21-29.

12. Cetinkaya M, Ozkan H, Koksal N, Solmaz Ç, Hacımustafaoğlu M. Comparison of serum amyloid A concentrations with those of C-reactive protein and procalcitonin in diagnosis and follow-up of neonatal sepsis in premature infants. J Perinatol 2009; 29: 225-231.

13. Korczowski B. Serum procalcitonin concentration in children with liver disease. Pediatr Infect Dis J 2006; 25: 268-269.

14. Malle E, Steinmetz A, Raynes JG. An acute phase protein and apolipoprotein. Atherosclerosis 1993; 102: 131-146.

15. Arnon S, Litmanovitz I, Regev RH, Bauer S, ShainkinKestenbaum R, Dolfin T. Serum amyloid A: an early and accurate marker of neonatal early-onset sepsis. J Perinatol 2007; 5: 297-302.

16. Rau B, Steinbach G, Baumgart K, Gansauge F, Gru¨nert A, Beger HG. Serum amyloid A versus C-reactive protein in acute pancreatitis: clinical value of an alternative acute-phase reactant. Crit Care Med 2000; 28: 736-742.

17. Mayer JM, Raraty M, Slavin J, et al. Serum amyloid A is a better early predictor of severity than C-reactive protein in acute pancreatitis. Br J Surg 2002; 89: 163-171.

18. Cetinkaya M, Ozkan H, Koksal N, Akacı O, Ozgur T. The efficacy of serial serum amyloid A measurements for diagnosis and follow-up of necrotizing enterocolitis in premature infants. Pediatr Surg Int 2010; 26: 835-841.

19. Cetinkaya M, Ozkan H, Koksal N, Akacı O, Ozgur T. Comparison of the efficacy of serial serum amyloid A, C-reactive protein and procalcitonin in the diagnosis and follow-up of necrotizing enterocolitis in premature infants. J Ped Surg 2011; 46: 1482-1489.

20. Feldman AG, Sokol RJ. Neonatal Cholestasis. Neoreviews 2013; 1: 14.

21. Goldstein B, Giroir B, Randolph A. International Consensus Conference on Pediatric Sepsis. International Pediatric Sepsis Consensus Conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6: 2-8.

22. Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 1986; 33: 179-201.

23. Kelly DA. Liver complications of pediatric parenteral nutrition: epidemiology. Nutrition 1998; 14: 153-157.

24. Jolin-Dahel K, Ferretti E, Montiyeros C, Grenon R, Barrowman N, Jimenaz-Rivera C. Parenteral nutritioninduced cholestasis in neonates: where does the problem lie? Gastroenterol Res Pract 2013; 2013: 163632.

25. Premkumar MH, Carter BA, Hawthrone KM, King K, Abrams SA. Fish oil based lipid emulsions in the treatment of parenteral nutrition associated liver disease: an ongoing positive experience. Adv Nutr 2014; 5: 65-70.

26. Chaudhari S, Kadam S. Total parenteral nutrition in neonates. Indian Pediatr 2006; 43: 953-964.

27. Kosters A, Karpen SJ. The role of inflammation in cholestasis- clinical and basic aspects. Semin Liver Dis 2010; 30: 186-194.

28. Vouloumanou EK, Plessa E, Karageorgopoulos DE, Mantadakis E, Falagas ME. Intensive Care Med 2011; 37: 747-762.

29. Rau B, Steinbach G, Baumgart K, Gansauge F, Grünert A, Beger HG. Serum amyloid A versus C-reactive protein in acute pancreatitis: clinical value of an alternative acute-phase reactant. Crit Care Med 2000; 28: 736-742.

30. Siegmund SV, Schlosser M, Schwabe RF, et al. Serum amyloid A induces inflammation, proliferation and cell death in activated hepatic stellate cells. PLOsOne 2016; 11: e0150893.