Uğur DEMİRSOY, Burcu ALPARSLAN, Mehmet Celal ŞEN, Yonca ANIK, Gür AKANSEL, Gözde GÖRÜR, Bora GÜREL, Görkem AKSU, Funda ÇORAPÇIOĞLU

More than Ophelia syndrome: Multiple paraneoplastic syndromes in pediatric Hodgkin lymphoma

ISSN: 0041-4301
Yayın Aralığı: Yılda 6 Sayı
Başlangıç: 1958
Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü

Paraneoplastic syndromes in Hodgkin lymphoma (HL) can be seen withdifferent symptoms and organ findings within a significant time beforedefinite diagnosis of the primary disease. Achalasia, Holmes-Adie pupil, andlimbic encephalitis are rarely reported paraneoplastic components in pediatricHL. In this report, we present an 11-year-old girl who had all these threeparaneoplastic components synchronously before HL was identified.

PDF

___

1. Graus F, Ariño H, Dalmau J. Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas. Blood 2014; 123: 3230-3238.

2. Juneja M, Kaur S, Mishra D, Jain S. Ophelia syndrome: Hodgkin lymphoma with limbic encephalitis. Indian Pediatr 2015; 52: 335-336.

3. Srinivasan A, Satish G, Scott JX, Madhavan R, Sathiyasekaran M. Two uncommon paraneoplastic neurological syndromes in a child with Hodgkin lymphoma. J Pediatr Hematol Oncol 2016; 38: 473-475.

4. Petersen CL, Hemker BG, Jacobson RD, Warwick AB, Jaradeh SS, Kelly ME. Wilms tumor presenting with Lambert-Eaton myasthenic syndrome. J Pediatr Hematol Oncol 2013; 35: 267-270.

5. Carr I. The Ophelia syndrome: Memory loss in Hodgkin’s disease. Lancet 1982; 1: 844-845.

6. Buyukpamukcu M, Buyukpamukcu N, Cevik N. Achalasia of the oesophagus associated with Hodgkin’s disease in children. Clin Oncol 1982; 8: 73-76.

7. Peeples WJ, El-Mahdi AM, Rosato FE. Achalasia of the esophagus associated with Hodgkin disease. J Surg Oncol 1979; 11: 213-216.

8. Katzka DA, Farrugia G, Arora AS. Achalasia secondary to neoplasia: A disease with a changing differential diagnosis. Dis Esophagus 2012; 25: 331-336.

9. Smith MA, Altekruse SF, Adamson PC, Reaman GH, Siebel NL. Declining childhood and adolescent cancer mortality. Cancer 2014; 120: 2497-2506.