Is there any relation between connective tissue growth factor and scar tissue in vesicoureteral reflux?
Vesicoureteral reflux (VUR) is the most common uropathy in childhoodwhich leads to increased frequency of urinary tract infection (UTI) andrenal scarring. Connective tissue growth factor (CTGF) plays an importantrole in the development of glomerular and tubulointerstitial fibrosis inprogressive kidney diseases. The aim of this study was to investigate therelation between urinary CTGF and renal damage resulted from VUR. Thiscross sectional study included 70 patients with VUR and 62 healthy sex andage matched children. Urinary creatinine and CTGF (uCTGF) concentrationswere analysed in all cases and CTGF to creatinine ratio were calculated.The records of radiologic evaluations of the patients including ultrasound,voiding cystouretrography and 99m-technetium dimercaptosuccinic acid(DMSA) scintigraphy were obtained retrospectively. The patient group wasfurther divided into two groups according to the existence of renal corticalscarring in the DMSA scan. The study consisted of three groups; Group1 (control group) 62 children, Group 2 (VUR positive, scar negative) 24patient, Group 3 (VUR positive, scar positive) 46 patient (VUR+scar). Themedians of uCTGF and uCTGF to creatinine ratio of the three groups weresignificantly different (p
___
1. Smellie JM, Normand IC. Bacteriuria, reflux, and renal scarring. Arch Dis Child 1975; 50: 581-585.2. Skoog SJ, Belman AB, Majd M. A nonsurgical approach to the management of primary vesicoureteral reflux. J Urol 1987; 138: 941-946.
3. Caione P, Ciofetta G, Collura G, Morano S, Capozza N. Renal damage in vesico-ureteric reflux. BJU Int 2004; 93: 591-595.
4. Szlyk GR, Williams SB, Majd M, Belman AB, Rushton HG. Incidence of new renal parenchymal inflammatory changes following breakthrough urinary tract infection in patients with vesicoureteral reflux treated with antibiotic prophylaxis: Evaluation by 99m-technetium dimercapto-succinic acid renal scan. J Urol 2003; 170: 1566-1569.
5. Swerkersson S, Jodal U, Sixt R, Stokland E, Hansson S. Relationship among vesicoureteral reflux, urinary tract infection and renal damage in children. J Urol 2007; 178: 647-651.
6. Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. Risk of renal scarring in children with a first urinary tract infection: A systematic review. Pediatrics 2010; 126: 1084-1091.
7. Jacobson SH, Eklöf O, Eriksson CG, Lins LE, Tidgren B, Winberg J. Development of hypertension and uraemia after pyelonephritis in childhood: 27 year follow up. BMJ 1989; 299: 703-706.
8. El-Khatib MT, Becker GJ, Kincaid-Smith PS. Reflux nephropathy and primary vesicoureteric reflux in adults. Q J Med 1990; 77: 1241-1253.
9. Claësson I, Jacobsson B, Jodal U, Winberg J. Compensatory kidney growth in children with urinary tract infection and unilateral renal scarring: An epidemiologic study. Kidney Int 1981; 20: 759-764.
10. Lahdes-Vasama T, Niskanen K, Rönnholm K. Outcome of kidneys in patients treated for vesicoureteral reflux (VUR) during childhood. Nephrol Dial Transplant 2006; 21: 2491-2497.
11. Dillon MJ, Goonasekera CD. Reflux nephropathy. J Am Soc Nephrol 1998; 9: 2377-2383.
12. Bob F, Gluhovschi G. Processes of fibrogenesis in glomerular nephropathies. TMJ 2004; 54: 297-307.
13. Qi W, Chen X, Poronnik P, Pollock CA. Transforming growth factor-beta/connective tissue growth factor axis in the kidney. Int J Biochem Cell Biol 2008; 40: 9-13.
14. Gilbert RE, Akdeniz A, Weitz S, et al. Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy. Diabetes Care 2003; 26: 2632-2636.
15. Nguyen T, Tarnow L, Andersen S, et al. Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy. Diabetes Care 2006; 29: 83-88.
16. Report of the International Reflux Study Committee. Medical versus surgical treatment of primary vesicoureteral reflux. Pediatrics 1981; 67: 392-400.
17. Imperiale A, Olianti C, Sestini S, et al. 123I-hippuran renal scintigraphy with evaluation of single-kidney clearance for predicting renal scarring after acute urinary tract infection: Comparison with (99m)TcDMSA scanning. J Nucl Med 2003; 44: 1755-1760.
18. Willemsen J, Nijman RJ. Vesicoureteral reflux and videourodynamic studies: Results of a prospective study. Urology 2000; 55: 939-943.
19. Wu C-Y, Chiu P-C, Hsieh KS, Chui CL, Shih CH, Chiou YH. Childhood urinary tract infection: A clinical analysis of 597 cases. Acta Paediatr Taiwan 2004; 45: 328-333.
20. Gonzalez E, Papazyan J-P, Girardin E. Impact of vesicoureteral reflux on the size of renal lesions after an episode of acute pyelonephritis. J Urol 2005; 173: 571-574.
21. O’Seaghdha CM, Hwang SJ, Bhavsar NA, et al. Lower urinary connective tissue growth factor levels and incident CKD stage 3 in the general population. Am J Kidney Dis 2011; 57: 841-849.
22. Karlen J, Linne T, Wikstad I, Aperia A. Incidence of microalbuminuria in children with pyelonephritic scarring. Pediatr Nephrol 1996; 10: 705-708.
23. Hunziker M, Colhoun E, Puri P. Renal cortical abnormalities in siblings of ındex patients with vesicoureteral reflux. Pediatrics 2014; 133: 933-937.
24. Kincaid-Smith P, Becker G. Reflux nephropathy and chronic atrophic pyelonephritis: A review. J Infect Dis 1978; 138: 774-780.
25. Bourchier D, Abbott GD, Maling TM. Radiological abnormalities in infants with urinary tract infections. Arch Dis Child 1984; 59: 620-624.
26. Yokoi H, Mukoyama M, Mori K, et al. Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice. Kidney Int 2008; 73: 446-455.
27. Wang S, Denichilo M, Brubaker C, Hirschberg R. Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy. Kidney Int 2001; 60: 96-105.
28. Roestenberg P, van Nieuwenhoven FA, Joles JA, et al. Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice. Am J Physiol Renal Physiol 2006; 290: 1344-1354.
29. Slagman M, Nguven T, Waanders F, et al. Effects of Antiproteinuric intervention on elevated connective tissue growth factor (CTGF/CCN-2) plasma and urine levels in nondiabetic nephropathy. Clin J Am Soc Nephrol 2011; 6: 1845-1850.
- ISSN: 0041-4301
- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 1958
- Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
Sayıdaki Diğer Makaleler
Intrathecal baclofen use in the management of tetanus related spasm: A case report
Güntülü ŞIK, Aydın AYDOSELİ, Agop ÇITAK
Bilateral Wilms tumors: Treatment results from a single center
Burça AYDIN, Canan AKYÜZ, Bilgehan YALÇIN, Saniye EKİNCİ, Berna OĞUZ, Zühal AKÇÖREN, Ferah YILDIZ, Ali VARAN, Nilgun KURUCU, Münevver BÜYÜKPAMUKÇU, Tezer KUTLUK
Zuhal BAYRAMOĞLU, Ravza YILMAZ, Ali Aslan DEMİR, Çigdem Ataizi ÇELİKEL, Faruk Erdem KOMBAK, Aygün İKİNCİ, Ensar YEKELER
Effect of iron supplementation during infancy period
Is serum procalcitonin level a reliable indicator in early diagnosis of congenital pneumonia?
Davut BOZKAYA, Şule YİĞİT, Murat YURDAKÖK
Murat KONAK, Murat MİNİCİ, Nuriye TARAKÇI, Hüseyin ALTUNHAN, Aysun TOKER, Rahmi ÖRS
Prolonged QT dispersion is associated with pediatric syncope
Meki BİLİCİ, Zübeyde Fidancı DEDEOĞLU, Fikri DEMİR, Alper AKIN, Mehmet TÜRE, Hasan BALIK, İlhan TAN, Sabahattin ERTUĞRUL
Jumana ALBARAMKİ, Haitham DMOUR, Mohammad SHBOUL, Carine BONNARD, Byrappa VENKATESH, Rasha ODEH
Body mass index is decreased in children and adolescents with postural tachycardia syndrome
Jing LİN, Huacai ZHAO, Lei MA, Fuyong JİAO
The pathogens and curative effects analysis of perianal abscess of infants under 3 months