Ferda ÖZKINAY, Osman ZEKİOĞLU, Özge ALTUN-KÖROĞLU1, Hüseyin ONAY2, Nilgün KÜLTÜRSAY, Mehmet YALAZ1, Fuat AKERCAN, Güzide AKSU, Gülin ERDEMİR, Şebnem ÇALKAVUR1

Mannose-binding lectin may affect pregnancy outcome

Çalkavur Ş, Erdemir G, Onay H, Altun-Köroğlu Ö, Yalaz M, Zekioğlu O, Aksu G, Özkınay F, Akercan F, Kültürsay N. Mannose-binding lectin may affect pregnancy outcome. Turk J Pediatr 2015; 57: 26-33.Mannose-binding lectin (MBL) is a component of the innate immune system and acts as a complement activator through the lectin pathway. Genetic variations of MBL and low MBL levels cause several infection problems, which may also be related to pregnancy problems. We aimed to investigate the role of MBL gene codon 54 polymorphism and serum MBL levels in pregnancy problems and premature delivery. In this prospective study,MBL gene codon 54 polymorphism and serum MBL levels were studied in 45 mothers who delivered earlier than 35 gestational weeks. The frequency of MBL gene codon 54 variant allele B was much higher (homozygous 4.4% and heterozygous 33.3%) in the study group mothers than the previously reported frequency in the healthy Turkish population (homozygous 2-6%, heterozygous 12-20%). MBL variant allele B frequency was closely related to low MBL levels (

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Cedzynski M, Swierzko AS, Kilpatrick DC. Factors of the lectin pathway of complement activation and their clinical associations in neonates. J Biomed Biotechnol 2012; doi: 10.1155/2012/363246.
Madsen HO, Satz ML, Hogh B, Svejgaard A, Garred P. Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J Immunol 1998; 161: 3169-3175.
Watts DH, Krohn MA, Hillier SL, Eschenbach DA. The association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor. Obstet Gynecol 1992; 79: 351-357.
Garred P, Madsen HO, Hofmann B, Svejgaard A. Increased frequency of homozygosity of abnormal mannan-binding-protein alleles in patients with suspected immunodeficiency. Lancet 1995; 346: 941- 943.
Worthley DL, Bardy PG, Mullighan CG. Mannose- binding lectin: biology and clinical implications. Intern Med J 2005; 35: 548-555.
Annells MF, Hart PH, Mullighan CG, Heatley SL, Robinson JS, McDonald HM. Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study. BMC Pregnancy Childbirth 2005; 5: 4.
Christiansen OB, Nielsen HS, Lund M, Steffensen R, Varming K. Mannose-binding lectin-2 genotypes and recurrent late pregnancy losses. Hum Reprod 2009; 24: 291-299.
Himes KP, Simhan HN. Genetic suspectibility to infection-mediated preterm birth. Infect Dis Clin N Am 2008; 22: 741-753.
Vianna P, Da Silva GK, Dos Santos BP, et al. Association between mannose-binding lectin gene polymorphisms and pre-eclampsia in Brazilian women. Am J Reprod Immunol 2010; 64: 359-374.
Koroglu OA, Onay H, Erdemir G, et al. Mannose- binding lectin gene polymorphism and early neonatal outcome in preterm infants. Neonatology 2010; 98: 305-312.
Swierzko AS, Atkinson AP, Cedzynski M, et al. Two factors of the lectin pathway of complement, I-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates. Mol Immunol 2009; 46: 551-558.
Gibbs RS, Duff P. Progress of pathogenesis and management of clinical intraamniotic infection. Am J Obstet Gynecol 1991; 164: 1317-1326.
Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. N Engl J Med 2000; 342: 1500-1507.
Hillier SL, Martius J, Krohn MA, Kiviat N, Holmes KK, Eschenbach DA. A case-control study of chorioamniotic infection and histological chorioamnionitis in prematurity. N Engl J Med 1988; 319: 972-978.
Onay H, Pehlivan M, Alper S, Ozkinay F, Pehlivan S. Might there be a link between mannose binding lectin and vitiligo? Eur J Dermatol 2007; 17: 146-148.
Koturoglu G, Onay H, Midilli R, et al. Evidence of an association between mannose binding lectin codon 54 polymorphism and adenoidectomy and/or tonsillectomy in children. Int J Pediatr Otorhinolaryngol 2007; 71: 1157-1161.
Burgner D, Jamieson SE, Blackwell JM. Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better? Lancet Infect Dis 2006; 6: 653-663.
Amirchaghmaghi E, Taghavi SA, Shapouri F, Saeidi S, Rezaei A, Aflatoonian R. The role of toll like receptors in pregnancy. Int J Fertil Steril 2013; 7: 147-154.
Kilpatrick DC, Starrs L, Moore S, Souter V, Liston WA. Mannan binding lectin concentration and risk of miscarriage. Hum Reprod 1999; 14: 2379-2380.
Annells MF, Hart PH, Mullighan CG, et al. Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: risk of preterm birth. Am J Obstet Gynecol 2004; 191: 2056-2067.
Bodamer OA, Mitterer G, Maurer W, Pollak A, Mueller MW, Schmidt WM. Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth. Genet Med 2006; 8: 518-524.
Babula O, Lazdane G, Kroica J, Ledger WJ, Witkin SS. Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women. Clin Infect Dis 2003; 37: 733-737.
Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis 2003; 37: 1496-1505.
Duff P. Management of premature rupture of membranes in term patients. Clinical Obstet Gynecol 1991; 34: 723-729.
Kilpatrick DC. Mannan-binding lectin and its role in innate immunity. Transfus Med 2002; 12: 335-352.
Fujita T, Matsushita M, Endo Y. The lectin-complement pathway—its role in innate immunity and evolution. Immunol Rev 2004; 198: 185-202.
Jack DL, Read RC, Tenner AJ, Frosch M, Turner MW, Klein NJ. Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitides serogroup B. J Infect Dis 2001; 184: 1152-1162.
van de Geijn FE, Dolhain RJ, van Rijs W, Hazes JM, de Groot CJ. Mannose-binding lectin genotypes and pre-eclampsia: a case control study. Hum Immunol 2007; 68: 888-893.
Celik N, Ozan H. Maternal serum mannose-binding lectin in severe preeclampsia. Clin Exp Obstet Gynecol 2008; 35: 179-182.
Megia A, Gallart L, Fernández-Real JM, et al. Mannose- binding lectin gene polymorphisms are associated with gestational diabetes mellitus. J Clin Endocrinol Metab 2004; 89: 5081-5087.