Derya BOZKURT, Ayşe SANDIKKAYA, Barış OTLU, Mukadder Ayşe SELİMOĞLU

Eight different viral agents in childhood acute gastroenteritis Original

Bozkurt D, Selimoğlu MA, Otlu B, Sandıkkaya A. Eight different viral agents in childhood acute gastroenteritis. Turk J Pediatr 2015; 57: 68-73.Viral gastroenteritis is the most frequent cause of acute gastroenteritis (AGE) of childhood. The aim of this study was to determine the prevalence of viral agents including astrovirus, rotavirus, adenovirus, enterovirus, norovirus, parechovirus, Aichivirus and sapovirus in children with AGE in a pediatric Turkish population. Fecal specimens of 240 children with AGE were investigated by polymerase chain reaction, and viral agents were identified in 131 (54.6%) samples. The distribution of viral agents was as follows: 56 (42.8%) norovirus, 44 (33.6%) rotavirus, 29 (22.1%) enterovirus, 21 (16.0%) adenovirus, 21 (16.0%) parechovirus, 5 (3.8%) sapovirus and 1 (0.8%) Aichivirus. Single and multiple viral agents were detected in 38.8% and 15.8% of patients, respectively. The duration of hospitalization was longer in children with multiple viral agents than in those infected with a single viral agent (p

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Elliott EJ. Acute gastroenteritis in children. BMJ 2007; 334: 35-40.
Bicer S, Sahin GT, Koncay B, et al. Incidence assessment of rotavirus and adenovirus associated acute gastroenteritis cases in early childhood. Infez Med 2011; 19: 113-119.
Guarino A, Albano F, Ashkenazi S, et al. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition/European Society for Paediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe. J Pediatr Gastroenterol Nutr 2008; 46: S81-S122.
Khamrin P, Okame M, Thongprachum A, et al. A single-tube multiplex PCR for rapid detection in feces of 10 viruses causing diarrhea. J Virol Methods 2011; 173: 390-393.
Ulukanlıgil M, Bakır M, Arslan G, Soran M, Seyrek A. [Investigation of diarrheal agents among 0–5-year-old children in Şanlıurfa]. [Article in Turkish] Mikrobiyol Bul 2001; 35: 307-312.
Kurugöl Z, Geylani S, Karaca Y, et al. Rotavirus gastroenteritis among children under five years of age in Izmir, Turkey. Turk J Pediatr 2003; 45: 290-294.
Özdemir S. Delialioğlu N. Emekdaş G. [Investigatıon of rotavirus, adenovirus and astrovirus frequencies in children with acute gastroenteritis and evaluation of epidemiological features]. [Article in Turkish] Mikrobiyol Bul 2010; 44: 571-578.
Tekin A. [The frequency of rotavirus and enteric adenovirus in children with acute gastroenteritis in Mardin]. [Article in Turkish] J Clin Experiment Invest 2010; 1: 41-45.
Moyo SJ, Gro N, Kirsti V, et al. Prevalence of enteropathogenic viruses and molecular characterization of group A rotavirus among children with diarrhea in Dar es Salaam Tanzania. BMC Public Health 2007; 7: 359.
Akihara S, Phan TG, Nguyen TA, Hansman G, Okitsu S, Ushijima H. Existence of multiple outbreaks of viral gastroenteritis among infants in a day care center in Japan. Arch Virol 2005; 150: 2061-2075.
Nakanishi K, Tsugawa T, Honma S, et al. Detection of enteric viruses in rectal swabs from children with acute gastroenteritis attending the pediatric outpatient clinics in Sapporo, Japan. J Clin Virol 2009; 46: 94-97.
Altindis M, Bányai K, Kalayci R, et al. Frequency of norovirus in stool samples from hospitalized children due to the acute gastroenteritis in Anatolia, Turkey, 2006-2007. Scand J Infect Dis 2009; 41: 685-688.
Uyar Y, Carhan A, Ozkaya E, Ertek M. [Evaluation of laboratory diagnosıs of the first norovirus outbreak in Turkey in 2008]. [Article in Turkish] Mikrobiyol Bul 2008; 42: 607-615.
Ozkul AA, Kocazeybek BS, Turan N, et al. Frequency and phylogeny of norovirus in diarrheic children in Istanbul, Turkey. J Clin Virol 2011; 51: 160-164.
Altay A, Bozdayı G, Meral M, et al. [Investigation of norovirus infection incidence among 0-5 years old children with acute gastroenteritis admitted to two different hospitals in Ankara, Turkey]. [Article in Turkish] Mikrobiyol Bul 2013; 47: 98-108.
Junquera CG, de Baranda CS, Mialdea OG, Serrano EB, Sánchez-Fauquier A. Prevalence and clinical characteristics of norovirus gastroenteritis among hospitalized children in Spain. Pediatr Infect Dis J 2009; 28: 604-607.
Ferreira MS, Xavier Mda P, Tinga AC, et al. Assessment of gastroenteric viruses frequency in a children’s day care center in Rio de Janeiro, Brazil: a fifteen year study (1994–2008). PLoS One 2012; 7: e33754.
Oldak E, Sulik A, Rozkiewicz D, Liwoch-Nienartowicz N, Zawadzka E. Norovirus and rotavirus—two major causative agents of sporadic viral gastroenteritis in hospitalized Polish children. Adv Med Sci 2009; 54: 183-186.
Albayrak N, Yağcı-Çağlayık D, Altaş AB, Korukluoğlu G, Ertek M. [Evaluation of the results of acute viral gastroenteritis data in Refik Saydam National Public Health Agency, Virology Reference and Research Laboratory in 2009]. [Article in Turkish] Turk Hij Den Biyol Derg 2011; 68: 9-15.
Koopmans M, Brown D. Seasonality and diversity of Group A rotaviruses in Europe. Acta Paediatr Suppl 1999; 88: 14-19.
Doğan N, Akgün Y. 0-6 yaş grubu gastroenterit olgularında rotavirus varlığı. İnfek Derg 1998; 12: 493-495.
Zarakolu P, Levent B, Gözalan A. İshalli çocuklarda rotavirüs ve enterik adenovirüs sıklığının araştırılması. Flora 1999; 4: 64-67.
Akdoğan D, Çınar S, Şahin İ, Per H, Kılıç H. 0-5 yaş çocuk ishallerinde rotavirüs araştırılması. İnfek Derg 2001; 15: 291-294.
Karadag A, Acikgoz ZC, Avcı Z, et al. Childhood diarrhoea in Ankara, Turkey: epidemiological and clinical features of rotavirus-positive versus rotavirus- negative cases. Scand J Infect Dis 2005; 37: 269-275.
Bozdayi G, Dogan B, Dalgic B, et al. Diversity of human rotavirus G9 among children in Turkey. J Med Virol 2008; 80: 733-740.
Bernstein DI, Ward RL. Rotaviruses. In: Feigin RD, Cherry JD, Demmler GJ, Kaplan SL (eds). Textbook of Pediatric Infectious Diseases (5th ed) Vol 2. Philadelphia, PA: Saunders; 2004: 2110-2133.
Velázquez FR, Matson DO, Guerrero ML, et al. Serum antibody as a marker of protection against natural rotavirus infection and disease. J Infect Dis 2000; 182: 1602-1609.
Parashar UD, Holman RC, Clarke MJ, Bresee JS, Glass RI. Hospitalizations associated with rotavirus diarrhea in the United States, 1993 through 1995: surveillance based on the new ICD-9-CM rotavirus- specific diagnostic code. J Infect Dis 1998; 177: 13-17.
American Academy of Pediatrics Committee on Infectious Diseases. Prevention of rotavirus disease: guidelines for use of rotavirus vaccine. Pediatrics 2007; 119: 171-182.
Uhnoo I, Svensson L, Wadell G. Enteric adenoviruses. Baillieres Clin Gastroenterol 1990; 4: 627-642.
Baskın E, Türkay S, Gökalp AS. [Adenovirus gastroenteritis]. [Article in Turkish] Türk Klin Tıp Bilim 1995; 15: 121-125.
Biçer S, Bezen D, Sezer S, et al. Acil çocuk servisindeki akut gastroenterit olgularında rotavirüs ve adenovirüs infeksiyonları. ANKEM Derg 2006; 20: 206-209.
Magalhães GF, Nogueria PA, Grava AF, Penati M, Silva LH, Orlandi PP. Rotavirus and adenovirus in Rondônia. Mem Inst Oswaldo Cruz 2007; 102: 555-557.
Tünger Ö, Özbakkaloğlu B, Sürücüoğlu S, Gündüz T. Akut gastroenteritli çocuklarda rotavirus ve adenovirus tip 40/41 sıklığının araştırılması. İnfek Derg 2001; 15: 43-46.
Gül M, Garipardıç M, Çıragil P, Aral M, Karabiber H, Güler İ. 0-5 yaş arası gastroenteritli çocuklarda rotavirüs ve adenovirüs tip 40/41 araştırılması. ANKEM Derg 2005; 19: 64-67.
Topkaya AE, Aksungar B, Özakkaş F, Çapan N. Examination of rotavirus and enteric adenovirus in children with acute gastroenteritis. Türk Mikrobiyol Cem Derg 2006; 36: 210-213.
Biçer S, Tunca Şahin G, Koncay B, ve ark. Çocuklarda adenovirus gastroenteriti olgularının sıklığı. Bakırköy Tıp Derg 2009; 5: 6-10.
Colomba C, De Grazia S, Giammanco GM, et al. Viral gastroenteritis in children hospitalised in Sicily, Italy. Eur J Clin Microbiol Infect Dis 2006; 25: 570-575.
Lin HC, Kao CL, Chang LY, et al. Astrovirus gastroenteritis in children in Taipei. J Formos Med Assoc 2008; 107: 295-303.
Harada S, Okada M, Yahiro S, et al. Surveillance of pathogens in outpatients with gastroenteritis and characterization of sapovirus strains between 2002 and 2007 in Kumamoto Prefecture, Japan. J Med Virol 2009; 81: 1117-1127.
Pham NT, Takanashi S, Tran DN, et al. Human parechovirus infection in children hospitalized with acute gastroenteritis in Sri Lanka. J Clin Microbiol 2011; 49: 364-366.
Pham NT, Trinh QD, Khamrin P, et al. Diversity of human parechoviruses isolated from stool samples collected from Thai children with acute gastroenteritis. J Clin Microbiol 2010; 48: 115-119.
Zhang DL, Jin Y, Li DD, et al. Prevalence of human parechovirus in Chinese children hospitalized for acute gastroenteritis. Clin Microbiol Infect 2011; 17: 1563- 1569.
Phan TG, Nguyen TA, Shimizu H, et al. IdentiŞcation of enteroviral infection among infants and children admitted to hospital with acute gastroentritis in Ho Chi Minh City. Vietnam. J Med Virol 2005; 77: 257- 264.
Lorrot M, Bon F, El Hajje MJ, et al. Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France. Eur J Clin Microbiol Infect Dis 2011; 30: 361-368.