Mehmet KILIÇ, Şilem Özdem ALATAŞ, Erdal TAŞKIN, Süleyman AYDIN, Mehmet Onur KAYA

Evaluation of serum/salivary levels of carnosine and cotinine in recurrent wheezing of young children with passive smoking

Background. Recurrent wheezing is common in young children, with a cumulative prevalence of up to 40 % in the first 6 years of life. In this study, we aimed to evaluate the relationship between the number of wheezing episodes and the number of cigarettes smoked at home and serum / saliva cotinine and carnosine levels in children with recurrent wheezing. Methods. This study was conducted with 80 young children with recurrent wheezing, aged between 1-4 years and 50 healthy control groups. Patient population was divided into three groups depending on the number of their exposure to cigarette smoke and wheezing attacks. Serum cotinine, saliva cotinine, serum carnosine, saliva carnosine, vitamin D levels were measured by using the ELISA method. Results. A significant relationship for serum cotinine and saliva cotinine levels was found between groups (p

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1. Alvarez-Alvarez I, Niu H, Guillen-Grima F, Aguinaga-Ontoso I. Meta-analysis of prevalence of wheezing and recurrent wheezing in infants. Allergol Immunopathol (Madr) 2018; 46: 210-217.

2. Mallol J, García-Marcos L, Solé D, Brand P; EISL Study Group. International prevalence of recurrent wheezing during the first year of life: variability, treatment patterns and use of health resources. Thorax 2010; 65: 1004-1009

3. Ashley MJ, Ferrence R. Reducing children’s exposure to environmental tobacco smoke in homes: issues and strategies. Tob Control 1998; 7: 61-65.

4. Di Franza JR, Aligne CA, Weitzman M. Prenatal and postnatal environmental tobacco smoke exposure and children’s health. Pediatrics 2004; 113(Suppl 4): 1007-1015.

5. Willers S, Axmon A, Feyerabend C, Nielsen J, Skarping G, Skerfving S. Assesment of environmental tobacco smoke exposure in children with asthmatic symptoms by questionnaire and cotinine concentrations in plasma, saliva, and urine. J Clin Epidemiol 2000; 53: 715-721.

6. Benowitz NL. Cotinine as a biomarker of environmental tobacco smoke exposure. Epidemiol Rev 1996; 18: 188-204.

7. Zalata A, Yahia S, El-Bakary A, Elsheikha HM. Increased DNA damage in children caused by passive smoking as assessed by comet assay and oxidative stres. Mutat Res 2007; 629: 140-147.

8. Aycicek A, Ozcan E, Kocyigit A. Decreased total antioxidant capacity and increased oxidative stres in passive smoker infants and their mothers. Pediatr Int 2005; 47: 635-639.

9. Powell CV, Nash AA, Powers HJ, Primhak RA. Antioxidant status in asthma. Pediatr Pulmonol 1994; 18: 34-38.

10. Boldyrev AA, Dupin AM, Bunin AY, Babizhaev MA, Severin SE. The antioxidative properties of carnosine, a natural histidine containing dipeptide. Biochem Int 1987; 15: 1105-1113.

11. Boldyrev AA, Aldini G, Derave W. Physiology and pathophysiology of carnosine. Physiol Rev 2013; 93: 1803-1845.

12. Tanaka KI, Kawahara M. Carnosine and lung disease. Curr Med Chem 2020; 27: 1714-1725.

13. Black PN, Scragg R. Relationship between serum 25- hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest 2005; 128: 3792-3798.

14. Jolliffe DA, Griffiths CJ, Martineau AR. Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies. J Steroid Biochem Mol Biol 2013; 136: 321-329.

15. Stragierowicz J, Mikolajewska K, Zawadzka-Stolarz M, Polanska K, Ligocka D. Estimation of cut off values of cotinine in urine and saliva for pregnant women in Poland. Biomed Res Int 2013; 2013: 386784.

16. Hallit S, Leynaert B, Delmas MC, et al. Wheezing phenotypes and risk factors in early life: The ELFE cohort. PLoS One 2018; 13: e0196711.

17. Martinez FD, Wright AL, Holberg CJ, Morgan WJ, Taussig LM. Maternal age as a risk factor for wheezing lower respiratory illnesses in the first year of life. Am J Epidemiol 1992; 136: 1258-1268.

18. Sherriff A, Peters TJ, Henderson J, Strachan D; ALSPAC Study Team. Avon Longitudinal Study of Parents and Children. Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1/2) years. Int J Epidemiol 2001; 30: 1473-1484.

19. Caudri D, Savenije OEM, Smit HA, et al. Perinatal risk factors for wheezing phenotypes in the first 8 years of life. Clin Exp Allergy 2013; 43: 1395-1405.

20. Benicio MHD, Ferreira MU, Cardoso MRA, Konno SC, Monteiro CA. Wheezing conditions in early childhood: prevalence and risk factors in the city of Sao Paulo, Brazil. Bull World Health Organ 2004; 82: 516-522.

21. Demirel S, Guner SN, Celiksoy MH, Sancak R. Is vitamin D insufficiency to blame for recurrent wheezing? Int Forum Allergy Rhinol 2014; 4: 980- 985.

22. Prasad S, Rana RK, Sheth R, Mauskar AV. A hospital based study to establish the correlation between recurrent wheeze and vitamin D deficiency among children of age group less than 3 years in Indian scenario. J Clin Diagn Res 2016; 10: SC18-SC21.

23. Dogru M, Seren LP. Serum 25-hydroxyvitamin D levels in children with recurrent wheezing and relation to the phenotypes and frequency of wheezing. Eur Ann Allergy Clin Immunol 2017; 49: 257-262.

24. Peat JK, Keena V, Harakeh Z, Marks G. Parental smoking and respiratory tract infections in children. Paediatr Respir Rev 2001; 2: 207-213.

25. Lux AL, Henderson AJ, Pocock SJ. Wheeze associated with prenatal tobacco smoke exposure: a prospective, longitudinal study. ALSPAC Study Team. Arch Dis Child 2000; 83: 307-312.

26. Gilliland FD, Berhane K, Islam T. Enviromental tobacco smoke and absenteeism related to respitory illness in school children. Am J Epidemiol 2003; 157: 861-869.

27. Hofhuis W, de Jongste JC, Merkus PJ. Adverse health effects of prenatal and postnatal tobacco smoke exposure on children. Arc Dis Child 2003; 88: 1086-1090.

28. Atay Ö, Pekcan S, Göktürk B, Özdemir M. Risk factors and clinical determinants in bronchiolitis of infancy. Turk Thorac J 2020; 21: 156-162.

29. Chen Y. Environmental tobacco smoke, low birth weight, and hospitalization for respiratory disease. Am J Respir Crit Care Med 1994; 150: 54-58.

30. Mannino DM, Caraballo R, Benowitz N, Repace J. Predictors of cotinine levels in US children: data from the Third National Health and Nutrition Examination Survey. Chest 2001; 120: 718-724.

31. Irvine L, Crombie IK, Clark RA, et al. What determines levels of passive smoking in children with asthma. Thorax 1997; 52: 766-769.

32. Willers S, Axmon A, Feyerabend C, Nielsen J, Skarping G, Skerfving S. Assessment of environmental tobacco smoke exposure in children with asthmatic symptoms by questionnaire and cotinine concentrations in plasma, saliva and urine. J Clin Epidemiol 2000; 53: 715-721.

33. Chang MY, Hogan AD, Rakes GP, et al. Salivary cotinine levels in children presenting with wheezing to an emergency department. Pediatr Pulmonol 2000; 29: 257-263.