Background. The objective of this study was to determine the effect of febrile convulsion (FC) on neuromotor development. Methods. Data of 325 patients, who were followed up at our outpatient clinic and diagnosed with FC between January 2012 and December 2018, were retrospectively evaluated. Of these patients, 203 underwent the Denver Developmental Screening Test II (DDST II) and were included in the study as the patient group and 100 healthy children as the control group. Results. Of the study group, 84 (41.4%) were girls and 119 (58.6%) were boys (B/G: 1.4). Of all patients, 163 (80.3%) were diagnosed with simple FC, 22 (10.8%) with complicated FC, and 18 (8.9%) with FC+. There was no significant relationship found between FC subtypes and gender, family history of FC, family history of epilepsy, iron (Fe) deficiency, and Fe deficiency anemia. DDST II subtest points were significantly lower in all developmental areas in the patient group when compared to the controls (p
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1.Guidelines for Epidemiologic Studies on Epilepsy. Commission on Epidemiology and Prognosis, International League Against Epilepsy. Epilepsia 1993; 34: 592-596.
2. Verity CM, Butler NR, Golding J. Febrile convulsions in a national cohort followed up from birth. I-Prevalence and recurrence in the first five years of life. Br Med J (Clin Res Ed) 1985; 290: 1307-1310.
3. Gupta A. Febrile seizures. Continuum (Minneap Minn) 2016; 22(Epilepsy 1): 51-59.
4. Wallace SJ. The Child with Febrile Seizures. London: John Wright, 1988: 109-126.
5. Daoud AS, Batieha A, Abu-Ekteish F, Gharaibeh N, Ajlouni S, Hijazi S. Iron status: a possible risk factor for the first febrile seizure. Epilepsia 2002; 43: 740- 743.
6. Garty BZ, Olomucki R, Lerman-Sagie T, Nitzan M. Cerebrospinal fluid zinc concentrations in febrile convulsions. Arch Dis Child 1995; 73: 338-341.
7. Nilsson G, Westerlund J, Fernell E, et al. Neurodevelopmental problems should be considered in children with febrile seizures. Acta Paediatr 2019; 108: 1507-1514.
8. Visser AM, Jaddoe VW, Ghassabian A, et al. Febrile seizures and behavioural and cognitive outcomes in preschool children: the Generation R study. Dev Med Child Neurol 2012; 54: 1006-1011.
9. Deonna T. Febrile seizures and behavioural and cognitive outcomes in preschool children: an old issue revisited. Dev Med Child Neurol 2012; 54: 969.
10. Yalaz K, Anlar B, Bayoğlu B. Denver II gelişimsel tarama testi. Ankara: Hacettepe Üniversitesi BasımYayım Koordinatörlüğü, 2009.
11. Riou EM, Ghosh S, Francoeur E, Shevell MI. Global developmental delay and its relationship to cognitive skills. Dev Med Child Neurol 2009; 51: 600-606.
12. Mussatto KA, Hoffmann RG, Hoffmann GM, et al. Risk and prevalence of developmental delay in young children with congenital heart disease. Pediatrics 2014; 133: e570-e577.
13. El Ters NM, Vesoulis ZA, Liao SM, Smyser CD, Mathur AM. Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants. Early Hum Dev 2018; 119: 68-72.
14. Knudsen FU, Westermark S. Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. Arch Dis Child 1978; 53: 660-663.
15. Okumura A, Uemura N, Suzuki M, Itomi K, Watanabe K. Unconsciousness and delirious behavior in children with febrile seizures. Pediatr Neurol 2004; 30: 316-319.
16. Choi YJ, Jung JY, Kim JH, et al. Febrile seizures: are they truly benign? Longitudinal analysis of risk factors and future risk of afebrile epileptic seizure based on the national sample cohort in South Korea, 2002-2013. Seizure 2019; 64: 77-83.
17. Şen Y, Şengül İ, Arslan N, Kabakuş N. Febril konvülziyonlar: 265 olgunun analizi. Turkiye Klinikleri J Pediatr 2008; 17: 75-79.
18. Shinnar S, Glauser TA. Febrile seizures. J Child Neurol 2002;17(Suppl 1): S44-S52.
19. Verrotti A, Latini G, di Corgia G, et al. Intermittent oral diazepam prophylaxis in febrile convulsions: its effectiveness for febrile seizure recurrence. Eur J Paediatr Neurol 2004; 8: 131-134.
20. Hauser WA, Annegers JF, Anderson VE, Kurland LT. The risk of seizure disorders among relatives of children with febrile convulsions. Neurology 1985; 35: 1268-1273.
21. Özaydın E, Yaşar MZ, Güven A, Değerliyurt A, Vidinlisan S, Köse G. Febril konvülziyonlu 1385 vakanın klinik özellikleri ve risk faktörleri. Türkiye Çocuk Hastalıkları Dergisi 2011; 5: 11-18.
22. Ling SG. Febrile convulsions: acute seizures characteristics and anti-convulsant therapy. Ann Trop Paediatr 2000; 20: 227-230.
23. Verity CM, Greenwood R, Golding J. Long‐term intellectual and behavioral outcomes of children with febrile convulsions. N Engl J Med 1998; 338: 1723-1728.
24. Leaffer EB, Hinton VJ, Hesdorffer DC. Longitudinal assessment of skill development in children with first febrile seizure. Epilepsy Behav 2013; 28: 83-87.
25. O’Donohoe NV. Febrile convulsions. In: Roger J, Bureau M, Dravet C, Dreius FE, Perret A, Wolf P (eds). Epileptic Syndromes in Infancy, Childhood and Adolescence (2nd ed) London: John Libbey, 1992; 418.
26. Verity CM. Febrile Convulsions. In: Anthony H, Simon S, Gregory C (eds). Epilepsy (2nd ed). London-New York: Chapman and Hall Medical, 1995; 675.
27. Bertelsen EN, Larsen JT, Petersen L, Christensen J, Dalsgaard S. Childhood epilepsy, febrile seizures, and subsequent risk of ADHD. Pediatrics 2016; 138: e20154654.
28. Weiss EF, Masur D, Shinnar S, et al; FEBSTAT Study Team. Cognitive functioning one month and one year following febrile status epilepticus. Epilepsy Behav 2016; 64(Pt A): 283-288.
29. Annegers JF, Hauser WA, Shirts SB, Kurland LT. Factors prognostic of unprovoked seizures after febrile convulsions. N Engl J Med 1987; 316: 493-498.
30. Hermann B, Seidenberg M. Epilepsy and cognition. Epilepsy Curr 2007; 7: 1-6.
31. Kolfen W, Pehle K, Konig S. Is the long-term outcome of children following febrile convulsions favorable? Dev Med Child Neurol 1998; 40: 667-671.
32. Tsai ML, Hung KL, Tsan YY, Tung WT. Long-term neurocognitive outcome and auditory event-related potentials after complex febrile seizures in children. Epilepsy Behav 2015; 47: 55-60.
33. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 2001; 131(2S-2): S649-S666.
34. Lozoff B, Jimenez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med 1991; 325: 687-694