Background. Congenital fibrinogen deficiency is one of the rare inherited coagulation disorders. Congenital fibrinogen deficiency complicated with a hematological malignancy can be life threatening. Case. We present a four-year-old girl with congenital fibrinogen deficiency complicated with acute lymphoblastic leukemia. Conclusion. This case aims to highlight therapeutic approaches for the management of afibrinogenemia patients with acute leukemia.
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