Acute necrotizing encephalopathy with organic psychosis: a pediatric case report
Background. Enteroviruses-associated acute necrotizing encephalopathy (ANE) of childhood is rarely reported in the literature. Clinico-radiological features of ANE are well-recognized and bilateral thalamic nuclei are frequently affected by ANE. Neuropsychiatric symptoms are rarely seen. Thalamic damage can cause psychosis. Case. Herein, we present a pediatric case of enterovirus-associated ANE presenting with psychosis related to thalamus damage in whom a favorable response to treatment was achieved. Conclusion. Thalamic damage occurs during the Enteroviruses-associated acute necrotizing encephalopathy and it can be related psychiatric sympthoms. Clinicians should be aware of uncommon presentations of ANE, and patients with thalamic damage should be followed for neuropsychiatric manifestations. Early recognition and appropriate treatment of ANE is important to obtain favorable outcomes.
___
1. Tabarki B, Thabet F, Al Shafi S, Al Adwani N, Chehab M, Al Shahwan S. Acute necrotizing encephalopathy associated with enterovirus infection. Brain Dev 2013; 35: 454-457.2. Mizuguchi M. Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain Dev 1997; 19: 81-92.
3. Wu X, Wu W, Pan W, Wu L, Liu K, Zhang HL. Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder. Mediators Inflamm 2015; 2015: 792578.
4. Voudris KA, Skaardoutsou A, Haronitis I, Vagiakou EA, Zeis PM. Brain MRI findings in influenza A-associated acute necrotizing encephalopathy of childhood. Eur J Paediatr Neurol 2001; 5: 199-202.
5. De Witte L, Brouns R, Kavadias D, Engelborghs S, De Deyn PP, Marien P. Cognitive, affective and behavioural disturbances following vascular thalamic lesions: a review. Cortex 2011; 47: 273-319.
6. Partlow GD, del Carpio-O'Donovan R, Melanson D, Peters TM. Bilateral thalamic glioma: review of eight cases with personality change and mental deterioration. AJNR Am J Neuroradiol 1992; 13: 1225-1230.
7. Okumura A, Mizuguchi M, Aiba H, Tanabe T, Tsuji T, Ohno A. Delirious behavior in children with acute necrotizing encephalopathy. Brain Dev 2009; 31: 594-599.
8. Glaser CA, Bloch KC. Encephalitis. In: Long SS, Prober CG, Fischer M (eds). Principles and Practice of Pediatric Infectious Diseases (5th ed). Philadelphia: Elsevier, 2018: 305-322.
9. Ravid S, Topper L, Eviatar L. Acute necrotizing encephalopathy presenting as a basal ganglia syndrome. J Child Neurol 2001; 16: 461-462.
10. Bradshaw MJ, Venkatesan A. Herpes simplex virus-1 encephalitis in adults: pathophysiology, diagnosis, and management. Neurotherapeutics 2016; 13: 493- 508.
11. Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T. Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol 2010; 9: 1097-1105.
12. Fowlkes AL, Honarmand S, Glaser C, et al. Enterovirus-associated encephalitis in the California encephalitis project, 1998-2005. J Infect Dis 2008; 198: 1685-1691.
13. McGilchrist I, Goldstein LH, Jadresic D, Fenwick P. Thalamo-frontal psychosis. Br J Psychiatry 1993; 163: 113-115.
14. Schulman JJ, Cancro R, Lowe S, Lu F, Walton KD, Llinás RR. Imaging of thalamocortical dysrhythmia in neuropsychiatry. Front Hum Neurosci 2011; 5: 69.
15. Cardosa J, Farrar J, Zijian F, et al. A Guide to Clinical Management and Public Health Response for Hand, Foot and Mouth Disease (HFMD). Geneva, Switzerland: World Health Organization Western Pacific Region, 2011.
16. Yamamoto H, Okumura A, Natsume J, Kojima S, Mizuguchi M. A severity score for acute necrotizing encephalopathy. Brain Dev 2015; 37: 322-327.
17. Kim JH, Kim IO, Lim MK, et al. Acute necrotizing encephalopathy in Korean infants and children: imaging findings and diverse clinical outcome. Korean J Radiol 2004; 5: 171-177.
18. Skatun KC, Kaufmann T, Brandt CL, et al. Thalamocortical functional connectivity in schizophrenia and bipolar disorder. Brain Imaging Behav 2018; 12: 640- 652.
19. Romero JR.Viral meningitis and the aseptic meningitis syndrome. In: Scheld WM, Whitley RJ, Marra CM, (eds). Infections of the Central Nervous System (4th ed). Philadelphia: Wolters Kluwer Health, 2014: 65-83.
20. Tunkel AR, Beek DV, Scheld WM. Acute meningitis. In: Bennett JE, Dolin R, Blaser MJ (eds). Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases (8th ed). Vol.1. Philadelphia: Churchill Livingstone Elsevier, 2015: 1097-1137.
21. Robinson CC, Willis M, Meagher A, Gieseker KE, Rotbart H, Glodé MP. Impact of rapid polymerase chain reaction results on management of pediatric patients with enteroviral meningitis. Pediatr Infect Dis J 2002; 21: 283-286.
22. Connoly KJ, Hammer SM. The acute aseptic meningitis syndrome. Infect Dis Clin North Am 1990; 4: 599-622.
23. Okumura A, Mizuguchi M, Aiba H, Tanabe T, Tsuji T, Ohno A. Delirious behavior in children with acute necrotizing encephalopathy. Brain Dev 2009; 31: 594-599.
24. Ai J, Xie Z, Liu G, et al. Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study. BMC Infect Dis 2017; 17: 494.
- ISSN: 0041-4301
- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 1958
- Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
Sayıdaki Diğer Makaleler
Tetanus; a forgotten infection disease: a report of two cases
Ülkem KOÇOĞLU BARLAS, Hasan Serdar KIHTIR, Osman YEŞİLBAŞ, Mey Talip PETMEZCİ, Nihal AKÇAY, Ercüment PETMEZCİ, Nevin HATİPOĞLU, Esra ŞEVKETOĞLU
BERİL DİLBER, Tülay KAMAŞAK, İLKER EYÜBOĞLU, Mehmet KOLA, Ahmet Taner UYSAL, Haluk SARIHAN, Hatice Sonay YALÇIN CÖMERT, Elif SAĞ, Ali CANSU
Mustafa ÇAKAN, Nuray AKTAY AYAZ, Şerife Gül KARADAĞ
The corrected QT interval prolongation in adolescents with cardiac iron overload β-thalassemia major
Najib ADVANI, Ahmad KAUTSAR, Murti ANDRIASTUTI
Pediatric case of persistent hiccups associated with hypertrophic olivary degeneration
Pınar ARICAN, Özgür ÖZTEKİN, Dilek ÇAVUŞOĞLU, Sema BOZKAYA YILMAZ, Atilla ERSEN, Nihal OLGAÇ DÜNDAR, PINAR GENÇPINAR
Clinical manifestation and outcomes of children with hypertrophic cardiomyopathy in Kosovo
Ramush A. BEJIQI, Ragip RETKOCERI, Naim ZEKA, Armend VUÇİTERNA, Aferdita MUSTAFA, Arlinda MALOKU, Rinor BEJIQI
Enrico MASIELLO, Antonio GATTO, Ilaria LAZZARESCHI, Donato RIGANTE, Paolo MARIOTTI, Piero VALENTINI
A rare case of syndromic severe congenital neutropenia: JAGN1 mutation
Funda ÇİPE, Çiğdem AYDOĞMUŞ, Avniye Kübra BASKIN, Gonca KESKİNDEMİRCİ, Wojciech GARNCARZ, Kaan BOZTUĞ