An infant with intradural extramedullary synovial sarcoma: the youngest case in the literature
An infant with intradural extramedullary synovial sarcoma: the youngest case in the literature
Spinal cord involvement of synovial sarcoma is extremely rare. So far onlytwo cases have been reported. Herein we describe the youngest case in theliterature. She is 14-month-old and first presented with difficulty in walkingongoing for a week. Imagining showed a spinal cord mass at C5-T3 levels.The patient had gone under Decompressive surgery and histopathologicexamination of the specimen revealed the presence of synovial sarcoma.Although the tumor regressed after chemotherapy, she was lost due to viralpneumonia. Synovial sarcoma should be kept in mind while evaluating spinaltumors even in infantile group.
___
- 1. Brennan B, Stevens M, Kelsey A, Stiller CA. Synovial sarcoma in childhood and adolescence: a retrospective series of 77 patients registered by the Children's Cancer and Leukaemia Group between 1991 and 2006. Pediatr Blood Cancer 2010; 55: 85-90.
- 2. Okcu MF, Munsell M, Treuner J, et al. Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J Clin Oncol 2003; 21: 1602-1611.
- 3. Eilber FC, Dry SM. Diagnosis and management of synovial sarcoma. J Surg Oncol 2008; 97: 314-320.
- 4. Ferrari A, Gronchi A, Casanova M, et al. Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer 2004; 101: 627-634.
- 5. Kim J, Lee SH, Choi YL, Bae GE, Kim ES, Eoh W. Synovial sarcoma of the spine: a case involving paraspinal muscle with extensive calcification and the surgical consideration in treatment. Eur Spine J 2014; 23: 27-31.
- 6. Puffer RC, Daniels DJ, Giannini C, Pichelmann MA, Rose PS, Clarke MJ. Synovial sarcoma of the spine: A report of three cases and review of the literature. Surg Neurol Int 2011; 2: 18.
- 7. de Ribaupierre S, Vernet O, Beck-Popovic M, Meagher-Villemure K, Rilliet B. Cervical nerve root synovial sarcoma in a child with chromosomal (X;18) translocation. Case report and review of the literature. Pediatr Neurosurg 2007; 43: 382-385.
- 8. Greene S, Hawkins DS, Rutledge JC, et al. Pediatric intradural extramedullary synovial sarcoma: case report. Neurosurgery 2006; 59: E1339.
- 9. Maurer HM, Beltangady M, Gehan EA, et al. The Intergroup Rhabdomyosarcoma Study-I. A final report. Cancer 1988; 61: 209-220.
- 10. Wilson P, Oleszek JL Clayton GH. Pediatric spinal cord tumors and masses. J Spinal Cord Med 2007; 30(Suppl 1): S15-S20.
- 11. Beall DP, Googe DJ, Emery RL, et al. Extramedullary intradural spinal tumors: a pictorial review. Curr Probl Diagn Radiol 2007; 36: 185-198.
- 12. Sandberg AA, Bridge JA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma. Cancer Genet Cytogenet 2002; 133: 1-23.
- 13. Brecht IB, Ferrari A, Int-Veen C, et al. Grosslyresected synovial sarcoma treated by the German and Italian Pediatric Soft Tissue Sarcoma Cooperative Groups: discussion on the role of adjuvant therapies. Pediatr Blood Cancer 2006; 46: 11-17.
- 14. Ferrari A, De Salvo GL, Brennan B, et al. Synovial sarcoma in children and adolescents: the European Pediatric Soft Tissue Sarcoma Study Group prospective trial (EpSSG NRSTS 2005). Ann Oncol 2015; 26: 567-572.
- 15. McCarville MB, Spunt SL, Skapek SX, Pappo AS. Synovial sarcoma in pediatric patients. AJR Am J Roentgenol 2002; 179: 797-801.
- 16. Sultan I, Rodriguez-Galindo C, Saab R, Yasir S, Casanova M, Ferrari A. Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005: an analysis of 1268 patients. Cancer 2009; 115: 3537-3547.
- 17. Orbach D, Mc Dowell H, Rey A, Bouvet N, Kelsey A, Stevens MC. Sparing strategy does not compromise prognosis in pediatric localized synovial sarcoma: experience of the International Society of Pediatric Oncology, Malignant Mesenchymal Tumors (SIOPMMT) Working Group. Pediatr Blood Cancer 2011; 57: 1130-1136.
- 18. Ferrari A, De Salvo GL, Dall'Igna P, et al. Salvage rates and prognostic factors after relapse in children and adolescents with initially localised synovial sarcoma. Eur J Cancer 2012; 48: 3448-3455.
- 19. Spunt SL, Poquette CA, Hurt YS, et al. Prognostic factors for children and adolescents with surgically resected nonrhabdomyosarcoma soft tissue sarcoma: an analysis of 121 patients treated at St Jude Children's Research Hospital. J Clin Oncol 1999; 17: 3697-3705.