Kadirhan SUNGUROĞLU, Toker ERGÜDER, Aslıhan AVCI, İmge B. ERGÜDER, Aslı UÇAR, Işıl ARITÜRK, Semiha HASIPEK

Üniversite öğrencilerinde sigara içmenin serum oksidan durum, kolesterol, homosistein, folik asit, bakır ve çinko seviyeleri üzerine etkileri

Amaç: Bu çalışmanın amacı üniversite öğrencilerinde sigara içiminin serum oksidan durum üzerineolan etkilerini araştırmakdı.Yöntem ve Gereç: Çalışmaya katılan kişiler Ankara Üniversitesi Fen Fakültesi öğrencileri arasındanrastgele seçildiler. Çalışma Ankara Üniversitesi Sağlık Bilimleri Fakültesi Beslenme ve DietetikBölümü ve Tıp Fakültesi Biyokimya Bölümünde gerçekleştirildi. Çalışmaya 44 gönüllü (22 sigaraiçen ve 22 içmeyen) katıldı. Serum örneklerinde malondialdehid, oksidasyona duyarlılık (OD),antioksidan potansiyel (AOP), total kolesterol, HDL kolesterol, LDL kolesterol, VLDL kolesterol,homosistein, folik asid, bakır ve çinko seviyeleri ölçüldü.Bulgular: Serum OD seviyeleri sigara içenlerde içmeyenlerden istatistiksel olarak anlamlı düzeydeyüksekti (sırasıyla; 1,01 ± 0,64 ve 0,49 ± 0,14).Sonuç: Sigara içme artmış oksidan stres (artmış oksidasyona duyaylılık) ve bozulmuş oksidansavunma sistemi nedenidir.

Anahtar Kelimeler:

Sigara içme, oksidasyona duyarlılık, ontioksidan potansiyel, kolesterol, homosistein, folik asid, bakır, çinko

The effects of cigarette smoking on serum oxidant status, and cholesterol, homocysteine, folic acid, copper, and zinc levels in university students

Aim: To examine the effect of cigarette smoking on serum oxidative damage and oxidant status in university students. Materials and Methods: Subjects were randomly chosen from among Ankara University Faculty of Science students. The study was performed at the Ankara University Faculty of Health Sciences, Department of Nutrition and Dietetics, and the Ankara University Faculty of Medicine, Department of Biochemistry. In all, 44 volunteer (22 smokers and 22 non-smokers) students participated in the study. Malondialdehyde, sensitivity to oxidation (SO), and antioxidant potential (AOP), and total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol, homocysteine, folic acid, copper, and zinc levels were measured in serum samples. Results: Serum SO levels were significantly higher in smokers than in non-smokers (1.01 ± 0.64 and 0.49 ± 0.14, respectively). Conclusions: Smoking history could be evidence of oxidative stress (high serum SO concentrations) and an impaired oxidant defense system.

Keywords:

Smoking, sensitivity to oxidation, antioxidant potential, cholesterol, homocysteine, folic acid, copper, zinc,

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