Işık ÜSTÜNER,
Serpil AYDOĞMUŞ,
Filiz AVŞAR,
Levent KESKİN,
Mehmet GÜMÜŞ,
Emel ŞİMŞEK,
Eda ÖZYİĞİT,
İsenlik SITKI,
Mustafa UZUN,
Ayşegül ÇİNKAYA,
Emine ÇELEN
5685
The Value of Ultrasonography and Tumor Markers in the Differential Diagnosis of Postmenopausal Ovarian Cysts
Aim: To evaluate the use of tumor markers in the differentiation of malignant and benign ovarian cysts in the postmenopausal period. Materials and Methods: The study included postmenopausal 46 patients with ovarian cysts that were assessed pre- and postoperatively using CA125 levels, ultrasonographic findings, and histopathological examination at the Obstetrics and Gynecology Clinic, Ankara Atatürk Training and Research Hospital. Results: Mean age of menopause onset was 46 years and mean duration of menopause was 11 years. Histopathological examination revealed that 28.3% of the ovarian cysts were malignant and 71.7% were benign. Of the malignant cysts, 84% were unilateral, with a mean diameter of 74.61 mm; mean diameter of the benign cysts was 58 mm. While 80% of cysts with a high CA125 value were malignant, 20% were benign. Pathological examination revealed that 96.8% of cysts with a normal CA125 value were benign and 3.2% were malignant. Mean CA125 values were 264 U/ml for malignant cysts and 14.2 U/ml for benign cysts. When pathological assessment was based only on ultrasonographic findings, 73.9% of the ovarian cysts were malignant and 26.1% were benign. While unilateral or bilateral localization in the ultrasonography was insignificant, the presence of a solid component was a good predictor of malignancy (P = 0.0001). Conclusions: In the differentiation of benign and malignant cysts in postmenopausal women, the presence of a solid component based on ultrasonography, cysts larger than 5-6 cm, and high CA125 values may be used as discriminative criteria. For those patients with cysts that are assumed to be benign follow-up may be an option for reducing the mortality and morbidity associated with surgery.
The Value of Ultrasonography and Tumor Markers in the Differential Diagnosis of Postmenopausal Ovarian Cysts
Aim: To evaluate the use of tumor markers in the differentiation of malignant and benign ovarian cysts in the postmenopausal period. Materials and Methods: The study included postmenopausal 46 patients with ovarian cysts that were assessed pre- and postoperatively using CA125 levels, ultrasonographic findings, and histopathological examination at the Obstetrics and Gynecology Clinic, Ankara Atatürk Training and Research Hospital. Results: Mean age of menopause onset was 46 years and mean duration of menopause was 11 years. Histopathological examination revealed that 28.3% of the ovarian cysts were malignant and 71.7% were benign. Of the malignant cysts, 84% were unilateral, with a mean diameter of 74.61 mm; mean diameter of the benign cysts was 58 mm. While 80% of cysts with a high CA125 value were malignant, 20% were benign. Pathological examination revealed that 96.8% of cysts with a normal CA125 value were benign and 3.2% were malignant. Mean CA125 values were 264 U/ml for malignant cysts and 14.2 U/ml for benign cysts. When pathological assessment was based only on ultrasonographic findings, 73.9% of the ovarian cysts were malignant and 26.1% were benign. While unilateral or bilateral localization in the ultrasonography was insignificant, the presence of a solid component was a good predictor of malignancy (P = 0.0001). Conclusions: In the differentiation of benign and malignant cysts in postmenopausal women, the presence of a solid component based on ultrasonography, cysts larger than 5-6 cm, and high CA125 values may be used as discriminative criteria. For those patients with cysts that are assumed to be benign follow-up may be an option for reducing the mortality and morbidity associated with surgery.
