Mehmet ATAŞ, Nergiz Hacer TURGUT, Ömer POYRAZ, Turabi GÜNEŞ

The seroprevalence of Rickettsia conorii in humans living in villages of Tokat Province in Turkey, where Crimean-Congo hemorrhagic fever virus is endemic, and epidemiological similarities of both infectious agents

Amaç: Tokat, Kırım-Kongo Hemorajik Ateş Virüsü (CCHFV) yönünden yüksek derece endemik bir yöredir. Bu çalışmanın amacı, Tokat yöresinde Rickettsia conoriinin seroprevalansını araştırmak ve CCHFVü ve Rickettsia conorii arasındaki epidemiyolojik benzerlikleri ortaya koymaktır. Yöntem ve gereç: 151i CCHFVü yönünden seropozitif olmak üzere, toplam 364 serum örneğinde ELISA yöntemi ile R. conorii ile reaktif antikorların prevalansı araştırılmıştır. Bulgular: R. conorii ile reaktif antikorların genel prevalansı % 36,81 olarak saptanmıştır. R. conorii enfeksiyonuna karşı oluşmuş antikor prevalansı, CCHFV seropozitifliği olanlarda, seronegatiflere göre daha yüksek tespit edilmiş olup sırasıyla % 52,32 ve % 25,82 oranlarında saptanmıştır (P = 0,001). Kene ısırığı öyküsü olanlarda % 41,52 ve olmayanlarda % 29,29 oranında görülmesiyle, gruplar arasında seroprevalans bakımından anlamlı bir farklılık bulunmuştur (P = 0,019). Sonuç: Bulgularımız CCHFV yönünden risk grubundan olan insanların R. conorii yönünden de risk grubundan olmasının muhtemel olduğunu göstermiştir.

Kırım Kongo hemorajik ateş virüsünün endemik olduğu Tokat ın köylerinde yaşayan insanlarda Rickettsia conorii seroprevalansı ve her iki enfeksiyon etkeninin epidemiyolojik benzerlikleri

Aim: Tokat Province is an epicenter for Crimean-Congo hemorrhagic fever virus (CCHFV) in Turkey. The aim of this study was to investigate the seroprevalence of Rickettsia conorii and to clarify the epidemiological similarities between CCHFV and R. conorii in Tokat Province. Materials and methods: The prevalence of antibodies reactive with R. conorii was examined by ELISA in 364 sera, 151 of which were seropositive for CCHFV. Results: The overall prevalence of antibodies reactive with R. conorii was 36.81%. The prevalence of antibodies to R. conorii infection was higher in humans who showed CCHFV seropositivity than seronegativity, 52.32% and 25.82%, respectively (P = 0.001). A significant difference in seroprevalence was found between groups who had a history of tick bite and who did not, 41.52% and 29.29%, respectively (P = 0.019). Conclusion: Our data show that people who are a risk group for CCHFV are likely to be a risk group for R. conorii.

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