Plasma lipid levels in patients with acute bacterial infections

To assess the impact of acute bacterial infections on plasma lipid levels and to determine the value of plasma lipid measurements in the diagnosis of acute bacterial infection. Materials and methods: A cross-sectional study was conducted involving 112 patients with acute bacterial infections admitted in hospital and 112 healthy individuals as controls. Levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein, and triglycerides were measured in blood samples of all subjects. Mean levels of serum lipids were compared in both groups. Results: Both groups were matched based on age (P = 0.10), sex (P = 0.789), BMI (P = 0.515), and history of diabetes mellitus (P = 0.231). Compared with control subjects, in patients with acute bacterial infections, significantly lower levels of total cholesterol (P = 0.013) and high-density lipoprotein cholesterol (P = 0.001) were found. There was no statistically significant differences in triglycerides (P = 0.194) and low-density lipoprotein (P = 0.075) serum levels between patients and controls. Conclusion: These results suggested that acute bacterial infections are associated with decreased serum cholesterol and high-density lipoprotein level. Therefore plasma lipids levels may serve as indicators of acute bacterial infections.

Anahtar Kelimeler:

Key words: Acute bacterial infections, lipoproteins, cholesterol, triglycerides

Plasma lipid levels in patients with acute bacterial infections

Keywords:

Key words: Acute bacterial infections, lipoproteins, cholesterol, triglycerides,

PDF

___

Emancipator K, Csako G, Elin RJ. In vitro inactivation of bacterial endotoxin by human lipoproteins and apolipoproteins. Infect Immun. 1992; 60: 596-601. 7. Carpentier YA, Scruel O. Changes in the concentration and composition of plasma lipoproteins during the acute phase response. Curr Opin Clin Nutr Metab Care 2002; 5: 153-8.
Khovidhunkit W, Memon RA, Feingold KR, Grunfeld C. Infection and infl ammation-induced proatherogenic changes of lipoproteins. J Infect Dis 2000; 181: 462-472. 9. Khosla SN, Goyle N, Seth RK. Lipid profi le in enteric fever. J Assoc Phys India 1991; 39: 260-2.
Alvarez C, Ramos A. Lipids, lipoproteins and apoproteins in serum during infections. Clin Chem 1986; 32: 142-5.
Wu A, Hinds CJ, Th iemermann C. High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications. Shock 2004; 21: 210-21.
Sammalkorpi K, Valtonen V, Kerttula Y, Nikkila E, Taskinen MR. Changes in serum lipoprotein pattern induced by acute infections. Metabolism 1988; 37: 859-65.
Hardardóttir I, Grünfeld C, Feingold KR. Eff ects of endotoxin and cytokines on lipid metabolism. Curr Opin Lipidol 1994; 5: 207-15.
Fraunberger P, Schaefer S, Werdan K, Walli AK, Seidel D. Reduction of circulating cholesterol and apolipoprotein levels during sepsis. Clin Chem Lab Med 1999; 37: 357-62.
Kaminska M, Badzio T, Ksiezopolska-Kaczorowska A, Bako W, Boj E, Przymanowski Z. High-molecular-weight lipoprotein concentrations in pneumonia in children. Problem Med Wieku Rozwoj 1983; 12: 363-75.
Gordon BR, Parker TS, Levine DM, Saal SD, Wang JC, Sloan BJ et al. Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients. Crit Care Med 2001; 29: 1563-8.
van Leeuwen HJ, Heezius EC, Dallinga GM, van Strijp JA, Verhoef J, van Kessel KP. Lipoprotein metabolism in patients with severe sepsis. Crit Care Med 2003; 31: 1359-66.
Ettinger WH, Varma VK, Sorci-Th omas M, Parks JS, Sigmon RC, Smith TK et al. Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. Arterioscler Th romb 1994; 14: 8-13.
Artl A, Marsche G, Lestavel S, Sattler W, Malle E. Role of serum amyloid A during metabolism of acute-phase HDL-C by macrophages. Arterioscler Th romb Vasc Biol 2000; 20: 763- 72.
Lüthold S, Berneis K, Bady P, Müller B.Eff ects of infectious disease on plasma lipids and their diagnostic signifi cance in critical illness. Eur J Clin Inves 2007; 37: 573-579.
Gruber M, Christ-Crain M, Stolz D, Keller U, Müller C, Bingisser R et al. Prognostic impact of plasma lipids in patients with lower respiratory tract infections – an observational study. Swiss Med Wkly 2009; 139: 166-72.
Vermont CL, den Brinker M, Kâkeci N, de Kleijn ED, de Rijke YB, Joosten KF et al. Serum lipids and disease severity in children with severe meningococcal sepsis. Crit Care Med 2005; 33: 1610-5.
Deniz O, Tozkoparan E, Yaman H, Cakir E, Gumus S, Ozcan O et al. Serum HDL-C levels, log (TG/HDL-C. serum total cholesterol/HDL-C ratios signifi cantly correlate with radiological extent of disease in patients with community- acquired pneumonia. Clin Biochem 2006; 39: 287-92. and
Henter JI, Carlson LA, Hansson M, Nilsson-Ehle P, Ortqvist E. Lipoprotein alterations in children with bacterial meningitis. Acta Paediatr 1993; 82: 694-8.
Kerttula Y, Weber T. Serum lipids in pneumonia of diff erent aetiology. Ann Clin Res 1988; 20:184-8.
Iscan A, Yigitoglu R, Onag A, Vurgun N, Ari Z, Ertan P et al. Should children with infection be tested for lipid, lipoprotein and apolipoprotein? Acta Paediatr Jpn 1998; 40: 47-51.
Gordon BR, Parker TS, Levine DM, Saal SD, Wang JC, Sloan BJ et al. Low lipid concentrations in critical illness: implications for preventing and treating endotoxemia. Crit Care Med 1996; 24: 584-9.