Fatma Esra GÜNAYDIN, Sedat ALTIN, Barış DEMİRKOL, Gülşah GÜNLÜOĞLU, Esma Nur AKTEPE, Nurdan KALKAN

The relationship between serum levels of surfactant protein D in COPD exacerbation severity and mortality

Background/aim: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. In COPD patients,various inflammatory markers such as cytokines and acute phase proteins, which show systemic inflammation in the circulation,increase during exacerbations. In our study, we aimed to determine the relationship between serum SP-D levels and exacerbationseverity, clinical course of the disease, and early mortality after discharge.Materials and methods: Fifty hospitalized patients with COPD acute exacerbation (46 male and 4 female) were recruited in this study.Thirty-three of the subjects (31 male and 2 female) were reevaluated after discharge. Venous blood samples were taken from all patientsand followed up for exacerbation frequency, hospital admission, and mortality for 12 months.Results: Serum SP-D levels in the stable period of the patients were lower than exacerbation (P < 0.001). The median exacerbationperiod SP-D level of the patients admitted to emergency department in the first month was statistically significantly higher than thatof the patients who were not admitted (P < 0.05) after discharge. There was a correlation between the rate of emergency admission andserum SP-D levels during the 12-month period after discharge (P = 0.04 (r = 0.29)).Conclusion: Our study showed that serum SP-D was found to be a useful biomarker in predicting emergency admission and predictorof the health status of COPD patients but did not predict early mortality after the exacerbation.

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