Adnan TAŞ, İbrahim Koral ÖNAL, Aysel ÜLKER, Bilge TUNÇ, Mehmet ARHAN, İsmail Hakkı KALKAN, Mevlüt KURT, Yasemin ÖZİN

Th e role of red cell distribution width as a marker in infl ammatory bowel disease

Amaç: Bu çalışma, kırmızı hücre dağılım hacminin, infl amatuar barsak hastalığı olan hastalarda, hastalık aktivitesinin değerlendirilmesinde kullanılabilirliğini belirlemek amacıyla yapılmıştır. Yöntem ve gereç: İnfl amatuar barsak hastalığı olan toplam 165 hasta (105 ülseratif kolit; 60 Crohn hastalığı) ve 43 sağlıklı kan donörü, tersiyer bir merkezde bu retrospektif çalışmaya dahil edildi. Hastaların tıbbi kayıtları klinik aktivite endeksi, kırmızı hücre dağılım hacmi, serum C reaktif protein, eritrosit sedimentasyon hızı, lökosit ve trombosit sayısı kaydedilmek için gözden geçirildi. Bulgular: Kırmızı hücre dağılım hacmi, serum C reaktif protein, eritrosit sedimantasyon hızı, trombosit sayısı ve artmış kırmızı hücre dağılım hacimli bireylerin oranı, kontrollerle karşılaştırıldığında hastalarda anlamlı bir biçimde yüksekti (P < 0,05). Kırmızı hücre dağılım hacmi ve artmış kırmızı hücre dağılım hacimli bireylerin oranı ülseratif kolit ile karşılaştırıldığında, Crohn hastalığı olan hastalarda daha yüksekti (P < 0,05). Kırmızı hücre dağılım hacmi, eritrosit sedimentasyon hızı, endoskopik aktivite indeksi (ülseratif kolitde) ve trombosit sayısı ile anlamlı bir biçimde ilişkiliydi (P < 0,05). Crohn hastalığının ülseratif kolitden ayrımında, kırmızı hücre dağılım hacmi kestirim değeri 14,45 için duyarlılık % 70, özgüllük % 56 idi. Sonuç: Kırmızı hücre dağılım hacmi, maliyet etkin bir araç olarak, infl amatuar barsak hastalığında hastalık aktivitesinin değerlendirilmesi için ek bir parametre ve Crohn hastalığının ülseratif kolitden ayrımında bir ek belirteç olabilir.

Kırmızı hücre dağılım hacminin infl amatuar barsak hastalığında belirteç olarak rolü

Aim: To determine whether red cell distribution width could be used for the assessment of disease activity in patients with infl ammatory bowel disease. Materials and methods: A total of 165 patients with infl ammatory bowel disease (105 ulcerative colitis; 60 Crohn’s disease) and 43 healthy blood donors were included in this retrospective study in a tertiary care setting. Th e medical records of the patients were reviewed to note clinical activity indices, red cell distribution width, serum C reactive protein, erythrocyte sedimentation rates, leukocyte, and platelet counts. Results: Red cell distribution width, serum C reactive protein, erythrocyte sedimentation rate, platelet count, and the proportion of individuals with increased red cell distribution width were all signifi cantly elevated in the patients compared to the controls (P < 0.05). Red cell distribution width and the proportion of patients having elevated red cell distribution width were higher in patients with Crohn’s disease compared with ulcerative colitis (P < 0.05). Red cell distribution width was signifi cantly correlated with erythrocyte sedimentation rate, endoscopic activity index (in ulcerative colitis), and platelet count (P < 0.05). For a red cell distribution width cut-off of 14.45 sensitivity for diff erentiation of Crohn’s disease from ulcerative colitis was 70% and specifi city was 56%. Conclusion: Red cell distribution width, as a cost-eff ective tool, could be an additional parameter to assess disease activity in infl ammatory bowel disease and an adjunctive marker in the diff erentiation between ulcerative colitis and Crohn’s disease.

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