Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia

Stenotrophomonas maltophilia is a nosocomial pathogen of increasing importance. Empiric antibiotic therapy for S. maltophilia infection is difficult because the microorganism is resistant to a number of agents typically used for health care associated infections, thus potentially increasing mortality. This study investigates 23 nosocomial pneumonia cases caused by S. maltophilia, the antibacterial sensitivity of the bacterium and the effect on mortality of suitable empiric therapy. Materials and methods: Twenty-three patients with nosocomial pneumonia caused by S. maltophilia between January 2000 and December 2006 at the Karadeniz Technical University Hospital were retrospectively investigated. Results: Suitable empiric therapy was used with 12 patients (52.2%), but the therapies administered to the other 11 patients were inappropriate for S. maltophilia infection. Eight (72.7%) of the patients who were not given suitable empiric antibiotherapy died (P = 0.002). Conclusion: The appropriate empiric antibiotic was administered to only 12 of the patients. The mortality rate among those patients to whom appropriate empiric antibiotics were not administered was high, proving that suitable empiric therapy is vitally important. Due to the increase in mortality, it is essential to initiate appropriate empiric therapy by carefully evaluating the risk factors for S. maltophilia in nosocomial pneumonia and taking sputum and bronchoalveolar lavage specimens without delay.

Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia

Stenotrophomonas maltophilia is a nosocomial pathogen of increasing importance. Empiric antibiotic therapy for S. maltophilia infection is difficult because the microorganism is resistant to a number of agents typically used for health care associated infections, thus potentially increasing mortality. This study investigates 23 nosocomial pneumonia cases caused by S. maltophilia, the antibacterial sensitivity of the bacterium and the effect on mortality of suitable empiric therapy. Materials and methods: Twenty-three patients with nosocomial pneumonia caused by S. maltophilia between January 2000 and December 2006 at the Karadeniz Technical University Hospital were retrospectively investigated. Results: Suitable empiric therapy was used with 12 patients (52.2%), but the therapies administered to the other 11 patients were inappropriate for S. maltophilia infection. Eight (72.7%) of the patients who were not given suitable empiric antibiotherapy died (P = 0.002). Conclusion: The appropriate empiric antibiotic was administered to only 12 of the patients. The mortality rate among those patients to whom appropriate empiric antibiotics were not administered was high, proving that suitable empiric therapy is vitally important. Due to the increase in mortality, it is essential to initiate appropriate empiric therapy by carefully evaluating the risk factors for S. maltophilia in nosocomial pneumonia and taking sputum and bronchoalveolar lavage specimens without delay.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkmedical147442, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2010}, volume = {40}, pages = {99 - 103}, doi = {}, title = {Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia}, key = {cite}, author = {Yılmaz, Gürdal and Özsu, Savaş and Köksal, İftihar and Özlü, Tevfik} }
APA Yılmaz, G , Özsu, S , Köksal, İ , Özlü, T . (2010). Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia . Turkish Journal of Medical Sciences , 40 (1) , 99-103 .
MLA Yılmaz, G , Özsu, S , Köksal, İ , Özlü, T . "Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia" . Turkish Journal of Medical Sciences 40 (2010 ): 99-103 <
Chicago Yılmaz, G , Özsu, S , Köksal, İ , Özlü, T . "Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia". Turkish Journal of Medical Sciences 40 (2010 ): 99-103
RIS TY - JOUR T1 - Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia AU - Gürdal Yılmaz , Savaş Özsu , İftihar Köksal , Tevfik Özlü Y1 - 2010 PY - 2010 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 99 EP - 103 VL - 40 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia %A Gürdal Yılmaz , Savaş Özsu , İftihar Köksal , Tevfik Özlü %T Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia %D 2010 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 40 %N 1 %R %U
ISNAD Yılmaz, Gürdal , Özsu, Savaş , Köksal, İftihar , Özlü, Tevfik . "Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia". Turkish Journal of Medical Sciences 40 / 1 (Ocak 2010): 99-103 .
AMA Yılmaz G , Özsu S , Köksal İ , Özlü T . Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia. Turkish Journal of Medical Sciences. 2010; 40(1): 99-103.
Vancouver Yılmaz G , Özsu S , Köksal İ , Özlü T . Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia. Turkish Journal of Medical Sciences. 2010; 40(1): 99-103.
IEEE G. Yılmaz , S. Özsu , İ. Köksal ve T. Özlü , "Suitable Empiric Antibiotic Therapy Saves Life in Nosocomial Pneumonia Caused by Stenotrophomonas maltophilia", Turkish Journal of Medical Sciences, c. 40, sayı. 1, ss. 99-103, Oca. 2010
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

33.3b30.7b

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