Prognostic role of homeostasis model assessment and oral glucose tolerance test in nondiabetic patients with Bell’s palsy
Prognostic role of homeostasis model assessment and oral glucose tolerance test in nondiabetic patients with Bell’s palsy
Background/aim: We aimed to reveal the incidence and predictive role of insulin resistance and distorted oral glucose tolerance test innondiabetic patients with Bell’s Palsy (BP).Materials and methods: Eighty-six patients with BP and 28 control subjects; all with normal blood glucose levels and no history ofdiabetes, were enrolled in the study. We investigated insulin resistance (IR) in all subjects, in terms of HOMA-IR greater than 2.7. Sixtytwoof the patients also underwent an oral glucose tolerance test (OGTT).Results: The mean HOMA-IR value was significantly increased in patients, compared to the control group (3.2 vs 1.6; P < 0.01). IR wasdetected more in BP patients than in controls (P < 0.05). The patients with higher HOMA-IR values had more severe facial dysfunctionat the initial presentation and complete recovery time took longer than the patients with normal HOMA-IR value (75 days vs 42 days; P< 0.05). Following a 2h-OGTT, impaired glucose tolerance and newly diagnosed DM were found in 60% of the patients. Recovery timewas significantly longer in prediabetics and newly diagnosed diabetic patients than in patients with normal glycemia (68 days, 52 days,and 32 days, respectively; P < 0.01).Conclusion: There is a strong linkage between HOMA-IR value and BP prognosis so HOMA-IR value may have a significant role ofpredicting BP prognosis at presentation.
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