Premarital screening of 466 Mediterranean women for serum ferritin, vitamin B12, and folate concentrations

Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus. We aimed to investigate hemoglobin, ferritin, folate, and vitamin B12 levels in preconceptional women in an area where a plant-based diet referred to as Mediterranean cuisine is commonly used. Materials and methods: The study population included 466 women between the ages of 18 and 45 years admitted for thalassemia screening. Sociodemographic variables and history of menometrorrhagia, pica, and dietary habits were collected. Serum vitamin B12, folate, ferritin, and hemoglobin levels were measured. Ferritin of Keywords: Vitamin B12, folate, ferritin, anemia Full Text: PDF
Anahtar Kelimeler:

Vitamin B12, folate, ferritin, anemia

Premarital screening of 466 Mediterranean women for serum ferritin, vitamin B12, and folate concentrations

Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus. We aimed to investigate hemoglobin, ferritin, folate, and vitamin B12 levels in preconceptional women in an area where a plant-based diet referred to as Mediterranean cuisine is commonly used. Materials and methods: The study population included 466 women between the ages of 18 and 45 years admitted for thalassemia screening. Sociodemographic variables and history of menometrorrhagia, pica, and dietary habits were collected. Serum vitamin B12, folate, ferritin, and hemoglobin levels were measured. Ferritin of Keywords: Vitamin B12, folate, ferritin, anemia Full Text: PDF

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  • Karabulut A, Şevket O, Acun A. Iron, folate and vitamin B12 levels in first trimester pregnancies in the Southwest region of Turkey. J Turk Ger Gynecol Assoc 2011; 12: 153–156.
  • WHO. WHO Global Database on Anaemia: Worldwide Prevalence of Anaemia 1993-2005. Geneva, Switzerland: WHO; 2008. Available online at http://whqlibdoc.who.int/ publications/2008/9789241596657_eng.pdf. 3. McArdle HJ, Ashworth CJ. Micronutrients in fetal growth and development. Br Med Bull 1999; 55: 499–510.
  • Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J 1993; 7: 1344–1353.
  • Tefferi A, Pruthi RK. The biochemical basis of cobalamin deficiency. Mayo Clin Proc 1994; 69: 181–186.
  • Ray JG, Wyatt PR, Thompson MD, Vermeulen MJ, Meier C, Wong PY, Summers AM, Farrell SA, Cole DE. Vitamin B12 and the risk of neural tube defects in a folic acid-fortified population. Epidemiology 2007; 18: 362–366.
  • Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull 2008; 29: S126–131.
  • Ray JG, Blom HJ. Vitamin B12 insufficiency and the risk of fetal neural tube defects. QJM 2003; 96: 289–295.
  • Ray JG, Meier C, Vermeulen MJ, Boss S, Wyatt PR, Cole DE. Association of neural tube defects and folic acid food fortification. Lancet 2002; 360: 2047–2048.
  • Thompson MD, Cole DE, Ray JG. Vitamin B-12 and neural tube defects: the Canadian experience. Am J Clin Nutr 2009; 89: 697S–701S.
  • Hu EA, Toledo E, Diez-Espino J, Estruch R, Corella D, Salas- Salvado J, Vinyoles E, Gomez-Gracia E, Aros F, Fiol M et al. Lifestyles and risk factors associated with adherence to the Mediterranean diet: a baseline assessment of the PREDIMED Trial. PLoS One 2013; 8: e60166.
  • Koehler KM, Romero LJ, Stauber PM, Pareo-Tubbeh SL, Liang HC, Baumgartner RN, Garry PJ, Allen RH, Stabler SP. Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J Am Coll Nutr 1996; 15: 364–376.
  • Watkins D, Whitehead MV, Rosenblatt DS. Megaloblastic anemia. In: Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE 4th, editors. Nathan and Oski’s Hematology of Infancy and Childhood. 7th ed. Philadelphia, PA, USA: WB Saunders; 2009. pp. 467–521.
  • WHO. The Prevalence of Anemia in Women: A Tabulation of Available Information. Geneva, Switzerland: Maternal Health and Safe Motherhood Program, World Health Organization; 1990.
  • Perkins SL. Red blood cell values at various ages: mean and lower limit of normal (-2SD). In: Greer JP, Foerster J, Rodgers GM, Lukens J, Paraskevas F, Glader B, editors. Wintrobe’s Clinical Hematology. 11th ed. Philadelphia, PA, USA: Williams & Wilkins; 2004. p. 2701.
  • Hagve TA, Lilleholt K, Svendsen M. Iron deficiency anaemia– interpretation of biochemical and haematological findings. Tidsskr Nor Laegeforen 2013; 133: 161–164.
  • Kayihan P, Dundar N. Prevalence & risk factors of anaemia among women of reproductive age in Bursa, Turkey. Indian J Med Res 2008; 128: 282–286.
  • Kilinc M, Yuregir G.T. Ekerbicer H. Anaemia and iron deficiency anaemia in south-east Anatolia. Eur J Haematol 2002; 69: 280–283.
  • Oner N, Vatansever U, Karasalihoğlu S, Ekuklu G, Celtik C, Biner B. The prevalence of folic acid deficiency among adolescent girls living in Edirne, Turkey. J Adolesc Health 2006; 38: 599–606.
  • Kirke PN, Molloy AM, Daly LE, Burke H, Weir DG, Scott JM. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993; 86: 703–708.
  • Von Schenck U, Bender-Gotze C, Koletzko B. Persistence of neurological damage induced by dietary vitamin B12 deficiency in infancy. Arch Dis Childhood 1997; 77: 137–139.
  • Balcı YI, Ergin A, Karabulut A, Polat A, Doğan M, Küçüktaşcı K. Serum vitamin B12 and folate concentrations and the effect of the Mediterranean diet on vulnerable populations. Pediatr Hematol Oncol 2014; 31: 62–67.
  • Koc A, Kocyigit A, Soran M, Demir N, Sevinc E, Erel O, Mil Z. High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa province of Turkey. Eur J Nutr 2006; 45: 291–297.
  • Molloy AM, Kirke PN, Troendle JF, Burke H, Sutton M, Brody LC, Scott JM, Mills JL. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification. Pediatrics 2009; 123: 917–923.
  • McLean E, de Benoist B, Allen L. Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr Bull 2008; 29: S38–S51.
  • Planells E, Sánchez C, Montellano MA, Mataix J, Llopis J. Vitamins B6 and B12 and folate status in an adult Mediterranean population. Eur J Clin Nutr 2003; 57: 777–785.
  • Ronnenberg AG, Wood RJ, Wang X, Xing H, Chen C, Chen D, Guang W, Huang A, Wang L, Xu X. Preconception hemoglobin and ferritin concentrations are associated with pregnancy outcome in a prospective cohort of Chinese women. J Nutr 2004; 134: 2586–2591.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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