Polymorphisms in ABC transporters (ABCA1 and ABCC8) in metabolic syndrome

To identify important single nucleotide polymorphisms (SNPs) in the ABCA1 and ABCC8 (SUR1) genes and determine if they are associated with metabolic syndorome (MetS). Materials and methods: Fifty-eight subjects fulfilling all 5 MetS criteria were chosen from 4809 subjects who participated in our screening study (Trabzon MetS study). Forty-three subjects who did not fulfill any MetS criteria were chosen as the control group. Genotyping of the samples after DNA isolation was performed by direct sequencing. For SNP analysis, exons 7, 15, 19, 36, 41, and 49 for ABCA1 and exons 16 and 18 for ABCC8 were selected. Results: The most important SNPs in the present study were R219K (AGG-AAG for codon 219 in exon 7) for ABCA1, and 16-3t (CTT-TTT for codon 723 in exon 16) and GAC-GAG for codon 760 in exon 18 for ABCC8. Conclusion: It was concluded that MetS may be associated with polymorphisms in ABCA1 and ABCC8.

Polymorphisms in ABC transporters (ABCA1 and ABCC8) in metabolic syndrome

To identify important single nucleotide polymorphisms (SNPs) in the ABCA1 and ABCC8 (SUR1) genes and determine if they are associated with metabolic syndorome (MetS). Materials and methods: Fifty-eight subjects fulfilling all 5 MetS criteria were chosen from 4809 subjects who participated in our screening study (Trabzon MetS study). Forty-three subjects who did not fulfill any MetS criteria were chosen as the control group. Genotyping of the samples after DNA isolation was performed by direct sequencing. For SNP analysis, exons 7, 15, 19, 36, 41, and 49 for ABCA1 and exons 16 and 18 for ABCC8 were selected. Results: The most important SNPs in the present study were R219K (AGG-AAG for codon 219 in exon 7) for ABCA1, and 16-3t (CTT-TTT for codon 723 in exon 16) and GAC-GAG for codon 760 in exon 18 for ABCC8. Conclusion: It was concluded that MetS may be associated with polymorphisms in ABCA1 and ABCC8.

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Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

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Clinical manifestations of 16 oropharyngeal tularemia patients: experience of a referral hospital in the city of Konya, Turkey

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The effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of rats

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Compliance to treatment and reaching of metabolic goals are better in OAD-treated diabetics than insulin-treated diabetics in the Turkish population

Yüksel ALTUNTAŞ, Okcan BASAT, Emine ŞATIR, Sema UÇAK

Comparison of the effects of intraarticular hyaluronic acid and antiinflammatory drug treatments on the surgical intervention rates in patients with gonarthrosis

Yalçın ERDOĞAN, İlhan GÜNAYDIN, Ayşe Yeşim GÖÇMEN, Murat KORKMAZ, Aylin OKUR

Polymorphisms in ABC transporters (ABCA1 and ABCC8) in metabolic syndrome

Yunus Emre YANDI, Mihriban AYVAZ, Arif Bayram HACIHASANOĞLU, Cihangir EREM, Orhan DEĞER

Comparison of the efficacies of I-gelTM and LMA-ProSealTM for airway management in pediatric patients

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Mehmet YILDIRIM, Mustafa AYYILDIZ, Erdal AĞAR, Duygu AYDIN

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