Sıtkı Samet ERMİŞ, Onur POLAT, Ümit Übeyt İNAN, Tuncay KÜSBECİ, Mahmut KARADAŞ, Güliz Fatma YAVAŞ

Comparison of latanoprost, brimonidine tartrate, and bimatoprost plus timolol maleate in fixed combinations

To compare the intraocular pressure (IOP)-lowering efficacy of fixed-combination antiglaucoma agents, and to evaluate the effect of these drugs on the visual field and optic disk morphology. Materials and methods: Included in this retrospective study were 17 eyes receiving latanoprost 0.005% + timolol maleate 0.5% fixed combination (group 1), 18 eyes receiving brimonidine tartrate 0.2% + timolol maleate 0.5% fixed combination (group 2), and 16 eyes receiving bimatoprost 0.03% + timolol maleate 0.5% fixed combination (group 3), all with the diagnosis of primary open-angle glaucoma or ocular hypertension. Intraocular pressure was measured by Goldmann applanation tonometer, a visual field test was performed, and optic disk morphology was evaluated by optic coherence tomography before the initiation of treatment and at the end of the follow-up period. The results were compared statistically. Results: All 3 fixed-combination drugs reduced IOP significantly compared to the baseline (for all groups, P < 0.001), although it was more pronounced in the group receiving the bimatoprost 0.03% + timolol maleate 0.5% fixed combination. No significant change was seen in the visual field and optic disk morphology in any group. Conclusion: All 3 fixed combinations are effective in lowering IOP and preserving the visual field and optic disk morphology.

Anahtar Kelimeler:

brimonidine tartrate, glaucoma, latanoprost

Comparison of latanoprost, brimonidine tartrate, and bimatoprost plus timolol maleate in fixed combinations

Keywords:

brimonidine tartrate glaucoma, latanoprost, Bimatoprost,

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