Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer

Öz Background/aim: A number of tumor markers detected in the serum or pathological specimens using immunohistochemical methods are used for early detection of malignancies and postoperative follow-up. Human leukocyte antigen-G (HLA-G) is a nonclassic HLA class I molecule. Recent studies suggested a relationship between HLA-G positivity and the stage or the phenotype of the malignancy. In this study, the relationship between serum HLA-G positivity and thyroid cancer was investigated. Materials and methods: Fifty patients with thyroid cancer and 45 healthy volunteers were included in this study. Serum HLA-G levels were measured using ELISA. Results: HLA-G was positive in only 3 out of 50 patients with thyroid cancer (2 papillary, 1 follicular type). On the other hand, HLA-G was positive in 20 out of 45 healthy subjects (P < 0.001). The prevalence of detectable levels of serum HLA-G was independent of sex and age in the whole study population. No correlation was found between serum HLA-G value and thyroid hormone profile, neither in papillary thyroid cancer nor follicular thyroid cancer patients. Conclusion: In this study, serum HLA-G was significantly less common in patients with thyroid cancer than in healthy controls.

Kaynak Göster

Bibtex @ { tbtkmedical576342, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {47}, pages = {1263 - 1266}, doi = {}, title = {Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer}, key = {cite}, author = {Akın, Murat and Aral, Latife Arzu and Yavuz, Aydin and Karabacak, Harun and Dikmen, Kürşat and Bostancı, Hasan} }
APA Akın, M , Aral, L , Yavuz, A , Karabacak, H , Dikmen, K , Bostancı, H . (2017). Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer . Turkish Journal of Medical Sciences , 47 (4) , 1263-1266 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45687/576342
MLA Akın, M , Aral, L , Yavuz, A , Karabacak, H , Dikmen, K , Bostancı, H . "Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer" . Turkish Journal of Medical Sciences 47 (2017 ): 1263-1266 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45687/576342>
Chicago Akın, M , Aral, L , Yavuz, A , Karabacak, H , Dikmen, K , Bostancı, H . "Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer". Turkish Journal of Medical Sciences 47 (2017 ): 1263-1266
RIS TY - JOUR T1 - Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer AU - Murat Akın , Latife Arzu Aral , Aydin Yavuz , Harun Karabacak , Kürşat Dikmen , Hasan Bostancı Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1263 EP - 1266 VL - 47 IS - 4 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer %A Murat Akın , Latife Arzu Aral , Aydin Yavuz , Harun Karabacak , Kürşat Dikmen , Hasan Bostancı %T Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 4 %R %U
ISNAD Akın, Murat , Aral, Latife Arzu , Yavuz, Aydin , Karabacak, Harun , Dikmen, Kürşat , Bostancı, Hasan . "Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer". Turkish Journal of Medical Sciences 47 / 4 (Ağustos 2017): 1263-1266 .
AMA Akın M , Aral L , Yavuz A , Karabacak H , Dikmen K , Bostancı H . Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer. Turkish Journal of Medical Sciences. 2017; 47(4): 1263-1266.
Vancouver Akın M , Aral L , Yavuz A , Karabacak H , Dikmen K , Bostancı H . Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer. Turkish Journal of Medical Sciences. 2017; 47(4): 1263-1266.
IEEE M. Akın , L. Aral , A. Yavuz , H. Karabacak , K. Dikmen ve H. Bostancı , "Plasma human leukocyte antigen-G (HLA-G) in patients with thyroid cancer", Turkish Journal of Medical Sciences, c. 47, sayı. 4, ss. 1263-1266, Ağu. 2017

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