Penile Mondor's disease can be effectively treated with the use of an acetyl salicylic acid and pentoxifylline combination

Amaç: Penil Mondor hastalığı nadir bir durum olduğundan, bugüne değin farklı tedavi yöntemleri kullanılmıştır. Bu nedenle biz de bu çalışmamızda Penil Mondor hastalığı olan 14 hastada asetil salisilik asit (ASA) ve pentoksifilin ile yeni bir tedavi stratejisi önerdik.Yöntem ve gereç: Bu çalışmaya penil Mondor hastalığı olan 14 hasta dahil edildi. Hastalara 14 gün boyunca ağız yoluyla ASA günde dört kez 500 mg ve pentoksifilin günde 2 kez 600 mg verildi. Fizik muayeneleri yapıldı. Tüm hastalara tedaviye başlamadan önce ve tedavinin 7. ve 14. günlerinde dorsal vendeki trombozisi değerlendirmek için ultrason yapıldı.Bulgular: Fizik muayenede 9 hastada koronal sulkusa paralel ve 5 hastada proksimal penisin dorsal yüzünde lezyonlar gözlendi. Tüm hastalarda peniste ağrılı endurasyon vardı. 7. Gün ultrasonlarında 8 hastada penil dorsal veninde trombüsle uyumlu hiperekoik yapılar gözlendi. 6 hastada ise trombus izlenmedi. 14. gün yapılan ultrasonlarında ise, 4 hastada penil dorsal vende trombüsle uyumlu hiperekoik yapılar tekrar gözlendi. Takip süresince hiçbir yan etkiyle karşılaşılmadı.Sonuç: Penil Mondor Hastalığının, vücudun diğer bölgelerinde gelişen trombotik olayların tedavisinde de kullanılan ASA ve pentoksifilin protokoluyla, önceki tedavi protokollerine oranla daha kısa sürede tedavi edilebileceğine inanıyoruz. Ancak kesin yargıya varmak için randomize kontrollü çalışmalara ihtiyaç vardır.

Penil Mondor hastalığı asetilsalisilik asit ve pentoksifilin kombinasyonu kullanarak etkili olarak tedavi edilebilir

Abstract: Since penile Mondor's disease is a rare condition, different treatment choices are used. Herein we recommend a new treatment strategy with acetylsalicylic acid and pentoxifylline, which was tested in 14 patients with penile Mondor's disease. Materials and methods: Fourteen patients with the clinical presentation of penile Mondor's disease were included. Patients were given acetylsalicylic acid (ASA) 500 mg qid and pentoxifylline 600 mg bid for 14 days. Physical examinations were performed in all patients. In addition, ultrasonic examinations were done before the treatment and on days 7 and 14 of treatment to evaluate dorsal vein thrombosis. Results: Physical examinations revealed lesions parallel to the coronal sulcus in 9 patients and in the dorsal aspect of the proximal penis in 5 patients. All patients had painful induration of the penis. On day 7, hyperechoic structures were still observed in 8 patients and no thrombus was seen in 6 patients. Ultrasonographic measurements were repeated 14 days after treatment and a hyperechoic structure was observed in 4 patients. No side effects were encountered during the follow-up period. Conclusion: We think that the ASA and pentoxifylline protocol, which is also used for the treatment of thrombotic events in other parts of the body, helps to resolve penile Mondor's disease in a shorter time compared to previous treatment protocols. Further randomized controlled studies are needed for a definitive decision.

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