Tevfik Berk BİLDACI, Esra CÖMERT ÇABUK, Özlem ÖZEN, Nefise Çağla TARHAN, Salih GÜLŞEN, Polat DURSUN, Burcu KARAKAYA KISA, Ali AYHAN

Outcomes in 12 gynecologic cancer patients with brain metastasis: A single center's experience

Amaç: İleri yaş bayan hastalarda, jinekolojik malignensiler; meme kanserinden sonra en sık gözüken ikinci kanserlerdir. Bu kanserler ilk olarak lokal yayılmaktadır ancak uzak metastazı akciğer, karaciğer, dalak ve lenf nodlarıdır. Beyin olağan metastaz yeri değildir. Bu çalışmadaki amacımız jinekolojik kanserle takip edilen 12 hastanın beyin metastazını literatür bilgisiyle beraber değerlerlendirmektir. Yöntem ve gereç: Farklı jinekolojik kanser tanısı alan 12 hasta retrospektif olarak araştırıldı. Terapötik modaliteler, yaşam süreleri, başlangıç cerrahisi zamanından; beyin metastazı olana kadar süredeki klinik gidişatları, CA-125 düzeyleri değerlendirildi. Bulgular: Over kanseri ile takip edilen 6 hastanın ortalama yaşam süresi 41,4 aydı. Diğer jinekolojik kanserlerdeki ortalama yaşam süresi ise 27,7 aydı. Servikal kanserler hariç CA-125 değeri beyin metastazı olduğu zaman yüksek seyretmekteydi. CA-125: 202 IU mL 1 idi. Beyin metastazı olduktan sonra yapılan cerrahi girişim veya verilen medikal tedavi arasında fark olmadığı saptanmıştır. Sonuç: Beyin metastazı tüm jinekolojik onkoloji kanserlerinde gözükebilir ve de yapılan multimodal tedavi yaklaşımlarına rağmen kötü prognoza sahiptir.

Kranial metastazı olan 12 jinekolojik onkoloji hastasının klinik gidişatı: Tek merkez deneyimi

Aim: To present 12 gynecologic cancer cases with brain metastasis and a discussion of the relevant literature. Gynecologic malignancy is the second most common cancer in elderly women, following breast cancer. Th ese cancers usually spread locally at fi rst, and common distant metastatic sites are the lungs, liver, spleen, and distant lymph nodes. Th e brain is not a usual site of metastatic involvement. Materials and methods: Th e study included 12 cases with various gynecologic malignancies that were retrospectively analyzed. Th erapeutic modalities, survival, and time between initial surgery and brain metastasis were recorded. Results: Th e mean survival was 41.4 months in 6 patients with ovarian cancer versus 27.7 months in those with other gynecological cancers. At the time of brain metastasis, the CA-125 level was elevated in all of the patients, except one that had cervical cancer. Th e mean CA-125 level was 202 IU mL 1. Th ere were no diff erences in the mean overall survival between the patients that underwent surgical resection and those that received medical treatment. Conclusion: Brain metastasis can occur in all gynecologic cancers and has a poor prognosis, despite multimodal treatment.

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