Reza VAZIRINEJAD, Roya NAJAFIPOUR, Mohsen REZAEIAN, Alireza GHAZIZADEH, Fateme DOUST MOHAMMADI

Opium and risk of gastrointestinal cancer: a case-control study

Background/aim: Gastrointestinal (GI) cancers are among the most common cancers in the world. Many risk factors may increasethe chance of developing GI cancers. In recent years, a number of epidemiological studies have reported evidence of carcinogenic effectsof opium in humans. This study aimed to investigate the relationship between opium use and GI cancer.Materials and methods: This case-control study was performed on 95 patients with GI cancer and 190 healthy individuals (matchedfor age, sex, place of residence, and smoking) in Rafsanjan, Iran, in 2018. Diet information, as well as history of smoking, the use ofhookah, opium, and its derivatives was collected using a checklist in interview sessions. Conditional logistic regression was performedto investigate the proposed relationship and to estimate odds ratios (OR).Results: After adjusting the confounding variables, the use of opium was significantly associated with an increased risk of GI cancerdevelopment (OR = 5.95, 95% CI: 2.4–14.9). Also, a dose-response association was found between the cumulative use of opium and therisk of GI cancers. Consumption of fruit and vegetables reduced the risk of developing GI cancers in opium users (OR = 4.9 and 4.7,respectively).Conclusion: Opium, in the form used among drug users in this area, can lead to an increased risk of GI cancers. Fruit and vegetableshave a protective and modifying effect on the risk of GI cancer development caused by opium consumption.

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