Hatice PAŞAOĞLU, Neslihan BUKAN, Gülsen BULDUK, Şevki ÇELEN

6490

Lipid Peroxidation, Nitrate and Nitrite Levels in Eclamptic and Intrauterine Growth Retarded Pregnancies

In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 µmol/L p < 0.001) and IUGR (24.3 ± 9.5 µmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 µmol /L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p < 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.
Anahtar Kelimeler:

Eclampsia, IUGR, nitric oxide, lipid peroxidation

Lipid Peroxidation, Nitrate and Nitrite Levels in Eclamptic and Intrauterine Growth Retarded Pregnancies

In this study we investigated nitric oxide metabolites nitrate+nitrite and lipid peroxidation product (malonyldialdehyde: MDA) related to the pathogenesis of eclampsia and intrauterine growth retarded (IUGR) pregnancy. Plasma nitrate+nitrite levels were higher in the eclamptic (31.6 ± 16.7 µmol/L p < 0.001) and IUGR (24.3 ± 9.5 µmol/L p < 0.005) groups than in the control group (18.8 ± 6.9 µmol /L). Plasma MDA levels were higher in the eclamptic group (5.5 ± 2.5 nmol/ml (p < 0.05) but not significantly different in the IUGR (3.4 ± 2.4 nmol/ml p > 0.05) group than control group (3.0 ± 1.3 nmol/ml). In addition, the plasma nitrite+nitrate and MDA levels in the eclamptic group were higher than in the IUGR group (p < 0.05). These variations could play different roles in the pathogenesis of eclampsia and IUGR pregnancy.
Keywords:

Eclampsia, IUGR, nitric oxide, lipid peroxidation,

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Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
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Lipid Peroxidation, Nitrate and Nitrite Levels in Eclamptic and Intrauterine Growth Retarded Pregnancies

Hatice PAŞAOĞLU, Neslihan BUKAN, Gülsen BULDUK, Şevki ÇELEN