Alpaslan ALP,
Cem ŞİMŞEK,
Osman DAĞ,
Tolga YILDIRIM,
Abdullah Tarık ASLAN,
Şefika AYAR,
Cavanşir VAHABOV,
Hakan GÖKER,
Yahya BÜYÜKAŞIK,
Halis ŞİMŞEK,
H. Yasemin BALABAN
2319
Lack of awareness of Hepatitis B screening and vaccination in high-risk group
Lack of awareness of Hepatitis B screening and vaccination in high-risk group
Background/aim: Hepatitis B virus (HBV) vaccination rates are insufficient in high-risk patients worldwide. This study aimed to investigate the screening, immunization, and vaccination rates in three high-risk groups for HBV infection: allogeneic hematopoietic stem cell transplantation (AHSCT), renal transplantation (RT), and chronic hepatitis C (CHC) groups. Materials and methods: The serological data of consecutive patients between 2014 and 2019 were reviewed using the hospital database. Results: The HBV screening rates were 100.0%, 90.4%, and 82.4% in the AHSCT, CHC, and RT groups, respectively (p = 0.003). The immunization rates against HBV through either previous exposure or vaccination were 79.5%, 71.7%, and 46.5% in the AHSCT, RT, and CHC groups, respectively (p < 0.001). The HBV vaccination rate was significantly low in the CHC group (71.5%, 69.0%, 34.6% in the AHSCT, RT, and CHC groups, respectively, p < 0.001). If patients lost their immunity due to immunosuppressive therapy were accounted, the vaccination rates increased to 95.2% in the AHSCT group and 72.9% in the RT group. The rate of annual screening for HBV status was 97.9% in the AHSCT group, but it was only 23.9% in the RT group. Conclusion: HBV screening and vaccination rates were significantly lower in the RT and CHC groups than in the AHSCT group.Key words: Vaccination, Hepatitis B virus, immunity
___
- 1. Salama, II, Sami SM, Said ZN, Salama SI, Rabah TM et al. Early and long term anamnestic response to HBV booster dose among fully vaccinated Egyptian children during infancy. Vaccine 2018; 36: 2005-2011. doi: 10.1016/j.vaccine.2018.02.103
- 2. Akyıldız M, Ahıskalı E, Zeybel M, Yurdaydın C. Regional epidemiology, burden and management of hepatits B virus in the Middle East. Clinical Liver Disease 2019; 14: 212-214. doi: 10.1002/cld.887
- 3. Gurol E, Saban C, Oral O, Cigdem A, Armagan A. Trends in hepatitis B and hepatitis C virus among blood donors over 16 years in Turkey. European Journal of Epidemiology 2006; 21: 299-305. doi: 10.1007/s10654-006-0001-2
- 4. Üner A, Kırımi E, Tuncer İ, Ceylan A, Türkdoğan MK et al. Seroepidemiology of hepatitis B virus infection in children in the Eastern Anatolia. Eastern Journal of Medicine 2001; 6: 40- 42.
- 5. Tozun N, Ozdogan O, Cakaloglu Y, Idilman R, Karasu Z et al. Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study. Clinical Microbiology and Infection 2015; 21: 1020-1026. doi: 10.1016/j. cmi.2015.06.028
- 6. Schillie S, Vellozzi C, Reingold A, Harris A, Haber P et al. Prevention of hepatitis B virus infection in the United States: recommendation of the Advisory Committee on Immunization Practices. MMWR. Recommendations and Reports 2018; 67: 1-31. doi: 10.15585/mmwr.rr6701a1
- 7. Burton CE, Doucette KE, Mabilangan CA, Plitt SS, Lee BE et al. Hepatitis B and C serologic profiles of Canadian organ donors and recipients: retrospective 10-year review at a single center. Transplant Infectious Disease 2016; 18: 520-528. doi: 10.1111/ tid.12558
- 8. Williams WW, Lu PJ, O’Halloran A, Kim DK, Ghroskopf LA et al. Surveillance of vaccination coverage among adult populations—United States, 2015. MMWR CDC Surveillance Summaries 2017; 66: 1–28. doi: 10.15585/mmwr.ss6611a1
- 9. Stroffolini T, Sagnelli E, Sagnelli C, Smedile A, Furlan C et al. The burden of HBV infection in HCV patients in Italy and the risk of reactivation under DAA therapy. Digestive and Liver Disease 2019; 51: 434-437. doi: 10.1016/j.dld.2018.09.010
- 10. Launay O, Le Strat Y, Tosini W, Kara L, Quelet S et al. Impact of free on-site vaccine and/or healthcare workers training on hepatitis B vaccination acceptability in high-risk subjects: a pre-post cluster randomized study. Clinical Microbiology and Infection 2014; 20: 1033-1039. doi: 10.1111/1469-0691.12689
- 11. Bini EJ, Perumalswami PV. Hepatitis B virus infection among American patients with chronic hepatitis C virus infection: prevalence, racial/ethnic differences, and viral interactions. Hepatology 2010; 51: 759-766. doi: 10.1002/hep.23461
- 12. Urbini Dos Santos C, Sevá-Pereira T, Alves-Filho G, Lorena SL, Soares EC et al. Changes in serological markers of hepatitis B virus after renal transplantation. Transplantation Proceedings 2008; 40: 749-751. doi: 10.1016/j.transproceed.2008.02.066
- 13. Çakar MK, Suyani E, Sucak GT, Altindal Ş, Aki SZ et al. HBV-related events after allogeneic hematopoetic stem cell transplantation in a center from Turkey. Annals of Hematology 2013; 92: 395-402. doi: 10.1007/s00277-012-1620-1