Akgün YAMAN, Salih ÇETİNER, Filiz KİBAR, Yaşar SERTDEMİR, Reyhan BİLİCİ SALMAN, Emrah SALMAN, Suade Özlem BADAK, Emine Duygu ERSÖZLÜ, Alev ÇETİN DURAN, Barış BORAL, Eren ERKEN

Importance of 14-3-3eta, anti-CarP, and anti-Sa in the diagnosis of seronegative rheumatoid arthritis

Background/aim: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation. The study aimed toassess serum 14-3-3eta, anti-CarP, and anti-Sa in seronegative RA (SNRA) patients who were treatment-naïve as well as in healthysubjects. This is the first study in the literature to examine these autoantibodies together in SNRA patients.Materials and methods: Forty-five treatment-naïve SNRA patients and 45 healthy subjects were recruited. Drugs change the levels ofautoantibodies; therefore, patients who took any medication had been excluded from our study. Anti-carbamylated protein, anti-Sa, and14-3-3eta were measured by using three different ELISA kits.Results: Median serum concentration of healthy controls in 14-3-3eta was 0.02 (0.02–0.27) ng/mL. Median serum concentration ofSNRA patients in 14-3-3eta was 1.00 (0.48–1.28) ng/mL. Data were analyzed with Mann–Whitney U tests; the P-value was

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