Does different subfertility etiology affect pregnancy rates in intrauterine insemination cycles?

Does different subfertility etiology affect pregnancy rates in intrauterine insemination cycles?

Background/aim: To investigate the relationship between subfertility etiologies and success rates in controlled ovarian stimulation andintrauterine insemination (COS–IUI) cycles.Materials and methods: The medical records of 218 couples who applied to a university-based fertility center were analyzedretrospectively. Detailed infertility examination data and pregnancy outcomes were compared according to different subfertilityetiologies. The study groups with regard to subfertility etiologies were minimal–mild endometriosis, unexplained infertility, and mildmale infertility. The primary outcome measure was live birth rate.Results: There were no statistically significant differences between the groups regarding demographics except for total motile spermcount. Live birth rates in the male infertility group were comparable to the endometriosis and unexpected infertility groups (6.6%,11.9%, and 10.3%, respectively; P = 0.63).Conclusion: The success rate of the mild male subfertility group following COS–IUI cycles for live birth rates was similar to those of theendometriosis and unexplained subfertility groups.

___

  • 1. Stephen EH, Chandra A. Declining estimates of infertility in the United States: 1982–2002. Fertility and Sterility 2006; 86(3): 516-523. doi: 10.1016/j.fertnstert.2006.02.129
  • 2. Dickey RP, Pyrzak R, Lu PY, Taylor SN, Rye PH. Comparison of the sperm quality necessary for successful intrauterine insemination with World Health Organization threshold values for normal sperm. Fertility and Sterility 1999; 71(4): 684-689. doi: 10.1016/s0015-0282(98)00519-6
  • 3. Kennedy S, Bergqvist A, Chapron C, D’Hooghe T, Dunselman G et al. ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group. ESHRE guidelines for the diagnosis and treatment of endometriosis. Human Reproduction 2005; 20(10): 2698-2704. doi: 10.1093/ humrep/dei135
  • 4. Practice Committee of the American Society for Reproductive Medicine. Effectiveness and treatment for unexplained infertility. Fertility and Sterility 2006; 86(5 Suppl 1): S111-S114. doi: 10.1016/j.fertnstert.2006.07.1475
  • 5. Francavilla F, Sciarretta F, Sorgentone S, Necozione S, Santucci R et al. Intrauterine insemination with or without mild ovarian stimulation in couples with male subfertility due to oligo/ astheno- and/or teratozoospermia or antisperm antibodies: a prospective cross-over trial. Fertility and Sterility 2009; 92(3): 1009-1011. doi: 10.1016/j.fertnstert.2009.01.112
  • 6. Hull MG. Effectiveness of infertility treatments: choice and comparative analysis. International Journal of Gynecology and Obstetrics 1994; 47(2): 99-108. doi: 10.1016/0020- 7292(94)90348-4
  • 7. Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD et al. Letrozole, gonadotropin, or clomiphene for unexplained infertility. The New England Journal of Medicine 2015; 373(13): 1230-1240. doi: 10.1056/NEJMoa1414827
  • 8. Veltman-Verhulst SM, Hughes E, Ayeleke RO, Cohlen BJ. Intra-uterine insemination for unexplained subfertility. Cochrane Database Systematic Review 2016; 19; 2:CD001838. doi: 10.1002/14651858.CD001838.pub5
  • 9. The European IVF-monitoring Consortium (EIM). European Society of Human Reproduction and Embryology (ESHRE), Calhaz-Jorge C, De Geyter C, Kupka MS, de Mouzon J, Erb K et al. Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE. Human Reproduction 2017; 32(10): 1957-1973. doi: 10.1093/humrep/ dex264
  • 10. Guzick, DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST et al. Sperm morphology, motility, and concentration in fertile and infertile men. The New England Journal of Medicine 2001; 345(19): 1388-1393. doi: 10.1056/ NEJMoa003005
  • 11. Van Voorhis BJ, Barnett M, Sparks AE, Syrop CH, Rosenthal G et al. Effect of the total motile sperm count on the efficacy and cost-effectiveness of intrauterine insemination and in vitro fertilization. Fertility and Sterility 2001; 75(4): 661-668. doi: 10.1016/s0015-0282(00)01783-0
  • 12. Cohlen BJ. Should we continue performing intrauterine insemination in the year 2004? Gynecologic and Obstetric Investigation 2005; 59(1): 3-13. doi:10.1159/000080492
  • 13. Kennedy S, Bergqvist A, Chapron C, D’Hooghe T, Dunselman G et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Human Reproduction 2005; 20(10): 2698-2704. doi: 10.1093/humrep/dei135
  • 14. Cissen M, Bensdorp A, Cohlen BJ, Repping S, de Bruin JP et al. Assisted reproductive technologies for male subfertility. Cochrane Database Systematic Review 2016; 2:CD000360. doi: 10.1002/14651858.CD000360.pub5
  • 15. Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: a committee opinion. Fertility and Sterility 2015; 103(3): e9-e17. doi: 10.1016/j.fertnstert.2014.12.093
  • 16. Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Human Reproduction Update 2006; 12(6): 685-718. doi: 10.1093/humupd/dml034
  • 17. Berker B, Kahraman K, Taskin S, Sukur YE, Sonmezer M et al. Recombinant FSH versus clomiphene citrate for ovarian stimulation in couples with unexplained infertility and male subfertility undergoing intrauterine insemination: a randomized trial. Archives of Gynecology and Obstetrics 2011; 284(6): 1561-1566. doi: 10.1007/s00404-011-1997-4
  • 18. Goverde AJ, McDonnell J, Vermeiden JP, Schats R, Rutten FF et al. Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-effectiveness analysis. Lancet 2000; 355(9197): 13-18. doi: 10.1016/S0140-6736(99)04002-7
  • 19. Bensdorp AJ, Cohlen BJ, Heineman MJ, Vandekerckhove P. Intra-uterine insemination for male subfertility. Cochrane Database Systematic Review 2007; 18(3): CD000360. doi: 10.1002/14651858.CD000360.pub4
  • 20. Bhattacharya S, Harrild K, Mollison J, Wordsworth S, Tay C et al. Clomifene citrate or unstimulated intrauterine insemination compared with expectant management for unexplained infertility: pragmatic randomised controlled trial. British Medical Journal 2008; 337: a716. doi: 10.1136/bmj.a716
  • 21. Wordsworth S, Buchanan J, Mollison J, Harrild K, Robertson L. et al. Clomifene citrate and intrauterine insemination as first-line treatments for unexplained infertility: are they cost effective? Human Reproduction 2011; 26(2): 369-375. doi: 10.1093/humrep/deq315
  • 22. Veltman-Verhulst SM, Cohlen BJ, Hughes E, Heineman MJ. Intra-uterine insemination for unexplained subfertility. Cochrane Database Systematic Review 2012; 9: CD001838. doi: 10.1002/14651858.CD001838.pub4
  • 23. Sicchieri F, Silva AB, Silva ACJSRE, Navarro PAAS, Ferriani RA et al. Prognostic factors in intrauterine insemination cycles. JBRA Assisted Reproduction 2018; 22(1): 02-07. doi: 10.5935/1518-0557.20180002
  • 24. Werbrouck E, Spiessens C, Meuleman C, D’Hooghe T. No difference in cycle pregnancy rate and in cumulative livebirth rate between women with surgically treated minimal to mild endometriosis and women with unexplained infertility after controlled ovarian hyperstimulation and intrauterine insemination. Fertility and Sterility 2006; 86(3): 566-571. doi: 10.1016/j.fertnstert.2006.01.044
  • 25. Prado-Perez J, Perez-Rivadeneira E, Sanon-Julien F. The impact of endometriosis on the rate of pregnancy of patients submitted to intrauterine insemination. Fertility and Sterility 2002; 77: S51. doi: 10.1016/S0015-0282(01)03182-X
  • 26. Ghaffari F, Sadatmahalleh SJ, Akhoond MR, Eftekhari Yazdi P, Zolfaghari Z. Evaluating the effective factors in pregnancy after intrauterine insemination: A retrospective study. International Journal of Fertility and Sterility 2015; 9(3): 300-308. doi: 10.22074/ijfs.2015.4544
  • 27. Wu HM, Tzeng CR, Chen CH, Chen PH. Pelvic endometriosis with peritoneal fluid reduces pregnancy rates in women undergoing intrauterine insemination. Taiwanese Journal of Obstetrics and Gynecology 2013; 52(4): 512-515. doi: 10.1016/j.tjog.2013.10.010
  • 28. Duffy JM, Arambage K, Correa FJ, Olive D, Farquhar C et al. Laparoscopic surgery for endometriosis. Cochrane Database Systematic Review 2014; 4: CD011031. doi: 10.1002/14651858. CD011031.pub2
  • 29. Miller DC, Hollenbeck BK, Smith GD, Randolph JF, Christman GM et al. Processed total motile sperm count correlates with pregnancy outcome after intra-uterine insemination. Urology 2002; 60(3): 497-501. doi: 10.1016/s0090-4295(02)01773-9
  • 30. Patel P, Carrasquillo R, Madhusoodanan V, Dadoun S, Patel A et al. Impact of abnormal sperm morphology on live birth rates following intrauterine insemination. Journal of Urology 2019; 101097JU0000000000000288. doi: 10.1097/ JU.0000000000000288
  • 31. Cohlen B, Bijkerk A, Van der Poel S, Ombelet W. IUI: review and systematic assessment of the evidence that supports global recommendations. Human Reproduction Update 2018; 24(3): 300-319. doi: 10.1093/humupd/dmx041
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Kinesiophobia and related factors in systemic lupus erythematosus patients

Deran OSKAY, Saliha KARATAY, Hamit KÜÇÜK, Şeminur HAZNEDAROĞLU, Songül BAĞLAN YENTÜR, Abdurrahman TUFAN

Neuroprotective role of delta opioid receptors in hypoxic preconditioning

Güleser GÖKTAŞ, Şevin GÜNEY, Gülnur TAKE KAPLANOĞLU, Sibel DİNÇER

Comparison of ultrasound-guided transversus abdominis plane block, quadratus lumborum block, and caudal epidural block for perioperative analgesia in pediatric lower abdominal surgery

Sinan YILMAZ, Deniz KARA, Shainaaz Su Sandar Lwin DOOPLY, Ayda TÜRKÖZ, Serdar YEŞİLTAŞ, Kazım KARAASLAN, Celal Bulut İPEK, Asım ESEN

Ultrasound-guided pulsed radiofrequency neuromodulation of the suprascapular nerve in partial rotator cuff tears

Sami EKSERT, Ender SİR

Asli ŞAHİNER, Ece HALAT, Evren Alğin YAPAR

Ben Zheng ZHOU, Da Hu ZHANG, Wei Min YU, Jin Zhuo NING

Is the version angle of the glenoid different in bone and cartilage? An MRI study

Burak KULAKOĞLU, Alper DEVECİ, Erman CEYHAN, Enver KILIÇ, Yahya Can DURA, Sualp TURAN, Guzelali ÖZDEMİR, Deniz SÖZMEN CILIZ

Kadir Serkan YALÇIN, Ali KOŞAR

Comparison of 2-year clinical and radiological outcomes between volar plating and external fixation with additional K-wires for AO Type C distal radius fractures

Uğur ÖZDEMİR, İzzet BİNGÖL, Levent BAYAM, Özgür ÇİÇEKLİ, Erhan ŞÜKÜR, Alauddin KOCHAİ

Incidence of second primary malignancies in patients with thyroid cancer in the Turkish population

Muhammet KOCABAŞ, İlker ÇORDAN, Feridun KARAKURT, Mustafa CAN, Mustafa KULAKSIZOĞLU, Melia KARAKÖSE