Handan KAYA, Sema HÜCÜMENOĞLU, Gülben ERDEM, Evrim DEMİRAY, Gülsün EKİCİOĞLU, Esin KOTİLOĞLU

8584

Hormonal Profile and Agnor Values in Pituitary Adenomas

Nucleolar organizer regions (NORs) are chromosomal segments in which ribosomal RNA is encoded. The AgNOR technique, which reveals these regions, has rarely been used in diagnosis and preceding the prognosis of pituitary adenoma. The purpose of this study was to evaluate the correlation of hormonal profile with the AgNOR counts, and the correlation of recurrence with the AgNOR counts and to determine the concordance between the evaluations of two different observers. This study included 33 patients wıth pituitary adenoma. The slides were stained with hematoxylin and eosin, silver colloid method for NORs and immunohistochemistry for the hormone expressions. Consistency was strong among the two pathologists (for hormonal profiling, the kappa test was used and p0. 05). In addition, we found no difference between recurrent patients and non-recurrent ones in terms of mean AgNOR numbers (p>0. 05). However, in recurrent patients, nucleolar silver staining was more frequently detected as clusters of AgNORs.
Anahtar Kelimeler:

Pituitary adenoma, AgNOR, immunohistochemistry, recurrence.

Hormonal Profile and Agnor Values in Pituitary Adenomas

Nucleolar organizer regions (NORs) are chromosomal segments in which ribosomal RNA is encoded. The AgNOR technique, which reveals these regions, has rarely been used in diagnosis and preceding the prognosis of pituitary adenoma. The purpose of this study was to evaluate the correlation of hormonal profile with the AgNOR counts, and the correlation of recurrence with the AgNOR counts and to determine the concordance between the evaluations of two different observers. This study included 33 patients wıth pituitary adenoma. The slides were stained with hematoxylin and eosin, silver colloid method for NORs and immunohistochemistry for the hormone expressions. Consistency was strong among the two pathologists (for hormonal profiling, the kappa test was used and p0. 05). In addition, we found no difference between recurrent patients and non-recurrent ones in terms of mean AgNOR numbers (p>0. 05). However, in recurrent patients, nucleolar silver staining was more frequently detected as clusters of AgNORs.
Keywords:

Pituitary adenoma, AgNOR, immunohistochemistry, recurrence.,

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Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
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