Endobronchial ultrasound-guided transbronchial needle biopsy for the diagnosis of mediastinal lymphadenopathy in patients with extrathoracic malignancies

Mediastinal lymphadenopathy is common in extrathoracic malignancies and should not always be considered a metastatic lesion. The purpose of this study is to determine the diagnostic value of endobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNA) in patients with extrathoracic malignancies. Materials and methods: This study included 54 consecutive patients with extrathoracic malignancies who had suspected mediastinal metastases and had undergone EBUS-TBNA for diagnosis. Results: Using EBUS-TBNA, 27 of 54 patients (50%) were diagnosed with mediastinal metastases. Among patients with mediastinal metastases, 2 (3.7%) had a sarcoid-like reaction, 5 (9.3%) had tuberculosis, and 17 (31.5%) had reactive lymph nodes. In 3 cases (5.5%), a specific diagnosis could not be determined following EBUS-TBNA. Two patients underwent surgical staging of their mediastinal lymphadenopathy, which allowed the detection of mediastinal metastases in 1 patient and that of reactive lymph nodes in the other. The sensitivity, specificity, negative predictive value, and diagnostic accuracy of EBUS-TBNA for the diagnosis of extrathoracic malignancies were calculated as 93%, 100%, 92.6%, and 96.3%, respectively. Conclusion: EBUS-TBNA is a safe and effective procedure. We should consider whether EBUS-TBNA should be the primary diagnostic tool for the diagnosis of mediastinal lymphadenopathy in patients with extrathoracic malignancies.

Endobronchial ultrasound-guided transbronchial needle biopsy for the diagnosis of mediastinal lymphadenopathy in patients with extrathoracic malignancies

Mediastinal lymphadenopathy is common in extrathoracic malignancies and should not always be considered a metastatic lesion. The purpose of this study is to determine the diagnostic value of endobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNA) in patients with extrathoracic malignancies. Materials and methods: This study included 54 consecutive patients with extrathoracic malignancies who had suspected mediastinal metastases and had undergone EBUS-TBNA for diagnosis. Results: Using EBUS-TBNA, 27 of 54 patients (50%) were diagnosed with mediastinal metastases. Among patients with mediastinal metastases, 2 (3.7%) had a sarcoid-like reaction, 5 (9.3%) had tuberculosis, and 17 (31.5%) had reactive lymph nodes. In 3 cases (5.5%), a specific diagnosis could not be determined following EBUS-TBNA. Two patients underwent surgical staging of their mediastinal lymphadenopathy, which allowed the detection of mediastinal metastases in 1 patient and that of reactive lymph nodes in the other. The sensitivity, specificity, negative predictive value, and diagnostic accuracy of EBUS-TBNA for the diagnosis of extrathoracic malignancies were calculated as 93%, 100%, 92.6%, and 96.3%, respectively. Conclusion: EBUS-TBNA is a safe and effective procedure. We should consider whether EBUS-TBNA should be the primary diagnostic tool for the diagnosis of mediastinal lymphadenopathy in patients with extrathoracic malignancies.

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Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Possible metabolic impact of Ramadan fasting in healthy men

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Effect of nodule size on the reliability of fine-needle aspiration biopsy in thyroid nodules

Ali Erkan UÇAR, Seyit Muhsin SARIKAYA, Ömer PARLAK, Abdussamed YALÇIN

Comparison of estrogen and betamethasone in the topical treatment of labial adhesions in prepubertal girls

Nazile ERTÜRK

The validity and reliability of the Turkish version of the University of Toronto Atrial Fibrillation Severity Scale

Nihan KAHYA EREN, Selcen YAKAR TÜLÜCE, Barış KILIÇASLAN, Cem NAZLI, Oktay ERGENE

A pilot experimental study of a catheter to facilitate treatment for penetrating cardiac injury

Mahmut TOKUR, Mehmet ERGİN, İbrahim Can KÜRKÇÜOĞLU, Zerrin Defne DÜNDAR

Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo

Emine Nur RİFAİOĞLU, Füsun AYDOĞAN, Bilge Bülbül ŞEN, Tuğba ŞEN, Özlem EKİZ

Effects of short-term hyperglycemia on the vasoconstriction of the aorta

Soner DÖNMEZ, Osman GÖKALP, Mustafa DOĞAN, Hüseyin VURAL, Barbaros YİĞİT

Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

İkbal KAYGUSUZ, Serap Aynur SİMAVLI, Ayla ESER, İlknur İNEGÖL GÜMÜŞ

Prohepcidin in maternal circulation: is it related to spontaneous preterm labor?

Yüksel ONARAN, Esra Aktepe KESKİN, Zehra Candan İltemir DUVAN

A new knot-supporting instrument and knot technique for laparoscopic surgery

Hasan BÖREKCİ, Elif BÖREKCİ, Hakan AK, Kürşad ZENGİN, Tugay ATALAY, Serhat TANIK