Mustafa Emre AKIN, Ayşegül Neşe ÇITAK KURT

Differences in corpus callosum morphology between healthy adolescents and adolescents with migraine: a case control study

Background/aim: This study objected to compare the measurements of corpus callosum substructures of adolescents with migraine and healthy adolescents. Materials and methods: In a case-control design, adolescents aged 12–18 years with the diagnosis of migraine and healthy control group had brain magnetic resonance imaging examination. The CC dimensions including anteroposterior length, truncus, genu and splenium widths of the case and control groups were measured and compared. Results: The sample consisted of 188 adolescents, 109 girls (58.0%), and 79 boys (42.0%). Of these 87 (46.3%) were in the migraine group and 101 (53.7%) were in the healthy control group. The mean genu and splenium width of the migraine group were significantly lower than the control group (p = 0.024 and p = 0.01 respectively). Conclusion: The results of this study firstly demonstrated that CC splenium and genu widths were smaller in adolescents with migraine when compared to healthy adolescents. Our findings may contribute to enlighten migraine pathophysiology.Key words: Migraine, corpus callosum, corpus callosum/diagnostic imaging, magnetic resonance imaging, child, adolescent

PDF

___

1. Greene K, Irwin SL, Gelfand AA. Pediatric migraine: an update. Neurologic Clinics 2019; 37 (4): 815-833. doi: 10.1016/j.ncl.2019.07.009
2. Lakhan SE, Avramut M, Tepper SJ. Structural and functional neuroimaging in migraine: insights from 3 decades of research. Headache 2013; 53 (1): 46-66. doi: 10.1111/j.1526- 4610.2012.02274.x
3. Sprenger T, Borsook D. Migraine changes the brain: neuroimaging makes its mark. Current Opinion in Neurology 2012; 25 (3): 252-262. doi: 10.1097/WCO.0b013e3283532ca3
4. Schwedt TJ, Dodick DW. Advanced neuroimaging of migraine. Lancet Neurology 2009; 8 (6): 560-568. doi: 10.1016/S1474- 4422(09)70107-3
5. Hamedani AG, Rose KM, Peterlin BL, Mosley TH, Coker LH et al. Migraine and white matter hyperintensities: the ARIC MRIstudy. Neurology 2013; 81 (15): 1308-1313. doi: 10.1212/WNL.0b013e3182a8235b
6. Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain: a systematic review and metaanalysis. Neurology 2013; 81 (14): 1260-1268. doi: 10.1212/WNL.0b013e3182a6cb32
7. Schmitz N, Admiraal-Behloul F, Arkink EB, Kruit MC, Schoonman GG et al. Attack frequency and disease duration as indicators for brain damage in migraine. Headache 2008; 48 (7): 1044-1055. doi: 10.1111/j.1526-4610.2008.01133.x
8. Rocca MA, Messina R, Colombo B, Falini A, Comi G et al. Structural brain MRI abnormalities in pediatric patients with migraine. Journal of Neurology 2014; 261 (2): 350-357. doi: 10.1007/s00415-013-7201-y
9. Tehrani KHN. An investigation of the prevalence of subclinical brain lesions in MRI images of migraine patients. Open Access Macedonian Journal of Medical Sciences 2018; 6 (7): 1239- 1243. doi: 10.3889/oamjms.2018.263
10. Candee MS, McCandless RT, Moore KR, Arrington CB, Minich LL, Bale JF Jr. White matter lesions in children and adolescents with migraine. Pediatric Neurology 2013; 49 (6): 393-396. doi: 10.1016/j.pediatrneurol.2013.08.025
11. Eidlitz-Markus T, Zeharia A, Haimi-Cohen Y, Konen O. MRI white matter lesions in pediatric migraine. Cephalalgia 2013; 33 (11): 906-913. doi: 10.1177/0333102413480955
12. Van der Knaap LJ, Van der Ham IJ. How does the corpus callosum mediate interhemispheric transfer? A review. Behavioural Brain Research 2011; 223 (1): 211-221. doi: 10.1016/j.bbr.2011.04.018
13. Horton JE, Crawford HJ, Harrington G, Downs JH 3rd. Increased anterior corpus callosum size associated positively with hypnotizability and the ability to control pain. Brain 2004; 127 (Pt 8): 1741-1747. doi: 10.1093/brain/awh196
14. Yuan K, Qin W, Liu P, Zhao L, Yu D et al. Reduced fractional anisotropy of corpus callosum modulates inter-hemispheric resting state functional connectivity in migraine patients without aura. PLoS One 2012; 7 (9): e45476. doi: 10.1371/journal.pone.0045476
15. Messina R, Rocca MA, Colombo B, Pagani E, Falini A et al. White matter microstructure abnormalities in pediatric migraine patients. Cephalalgia 2015; 35 (14): 1278-1286. doi: 10.1177/0333102415578428
16. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018; 38 (1): 1- 211. doi: 10.1177/0333102417738202
17. Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. Brain 1989; 112 (3): 799-835. doi:10.1093/brain/112.3.799
18. Fabri M, Polonara G. Functional topography of human corpus callosum: an FMRI mapping study. Neural Plasticity 2013; 2013: 251308. doi: 10.1155/2013/251308
19. Coppola G, Di Renzo A, Tinelli E, Petolicchio B, Di Lorenzo C et al. Patients with chronic migraine without history of medication overuse are characterized by a peculiar white matter fiber bundle profile. Journal of Headache and Pain 2020; 21 (1): 92. doi: 10.1186/s10194-020-01159-6
20. Li R, Chang N, Liu Y, Zhang Y, Luo Y et al. The integrity of the substructure of the corpus callosum in patients with right classic trigeminal neuralgia-a diffusion tensor imaging study. Journal of Craniofacial Surgery 2020. doi: 10.1097/SCS.0000000000007082
21. Ünver O, Kutlubay B, Besci T, Ekinci G, Baltacıoğlu F et al. Transient splenial lesion of the corpus callosum related to migraine with aura in a pediatric patient. Acta Medica (Hradec Kralove) 2016; 59 (2): 64-66. doi: 10.14712/18059694.2016.91
22. Lin FY, Yang CY. Reversible splenial lesion of the corpus callosum in migraine with aura. Neurologist 2011; 17 (3): 157- 159. doi: 10.1097/NRL.0b013e31821733c2