Quantitative analysis of distal femoral epiphysis blood supply in healthy infants with superb microvascular imaging: a pilot study

Quantitative analysis of distal femoral epiphysis blood supply in healthy infants with superb microvascular imaging: a pilot study

Background/aim: This study aimed to determine the blood supply of the distal femoral epiphysis (DFE) using superb microvascular imaging in newborns and infants, and to investigate the correlation with ossification center (OC) length, sex, and age. Materials and methods: A total of 140 cases were evaluated in this study. The cases were divided into 2 groups of less than 90 days and over 90 days. Cartilage blood supply was measured with vascularity index (%) (VI). Results: The mean OC length and median VI values were measured as 10.20 ± 3.72 mm and 0.80% (0.58–1.50) for boys and 10.03 ± 3.36 mm and 0.70% (0.30–1.40) for girls, respectively. There was no significant difference in OC length and VI between sexes. The mean OC length in Group II was significantly higher than in Group I (12.14 ± 3.14 vs 8.09 ± 2.64) (p < 0.001). The median VI in Group I was higher than in Group II (1.40% vs 0.40%) (p < 0.001). There were positive correlations between age and OC length (r = 0.716), negative correlations between age and VI (r = –0.822), and between VI and OC length (r = –0.657). Conclusion: Quantitative reference values for DFE blood supply and OC length can guide the diagnosis and follow-up of many skeletal diseases.Key words: Blood supply, distal femoral epiphysis, infant, newborn, superb microvascular imaging, ultrasound

___

  • 1. Jiang ZZ, Huang YH, Shen HL, Liu XT. Clinical applications of superb microvascular imaging in the liver, breast, thyroid, skeletal muscle, and carotid plaques. Journal of Ultrasound in Medicine 2019; 38 (11): 2811-2820. doi: 10.1002/jum.15008
  • 2. Machado P, Segal S, Lyshchik A, Forsberg F. A novel microvascular flow technique: initial results in thyroids. Ultrasound Quarterly 2016; 32 (1): 67-74. doi: 10.1097/RUQ.0000000000000156
  • 3. Gitto S, Messina C, Chianca V, Tuscano B, Lazzara A et al. Superb microvascular imaging (SMI) in the evaluation of musculoskeletal disorders: a systematic review. La Radiologia Medica 2020; 125 (5): 481-490. doi: 10.1007/s11547-020- 01141-x
  • 4. Lim AKP, Satchithananda K, Dick EA, Abraham S, Cosgrove DO. Microflow imaging: New Doppler technology to detect lowgrade inflammation in patients with arthritis. European Radiology 2018; 28 (3): 1046-1053. doi: 10.1007/s00330- 017-5016-4
  • 5. Savino A, Carinci S, Bucci I, Sabatino G, Chiarelli F et al. Bone maturity and thyroidal status at birth: role of the ultrasonographic evaluation of the distal femoral epiphysis. Ultraschall in der Medizin 2011; 32 (2): E129-133. doi: 10.1055/s-0031-1281972
  • 6. Arslan S, Karahan AY, Oncu F, Bakdik S, Durmaz MS et al. diagnostic performance of superb microvascular imaging and other sonographic modalities in the assessment of lateral epicondylosis. Journal of Ultrasound in Medicine 2018; 37 (3): 585-593. doi: 10.1002/jum.14369
  • 7. Eliahou R, Simanovsky N, Hiller N, Simanovsky N. Fractureseparation of the distal femoral epiphysis in a premature neonate. Journal of Ultrasound in Medicine 2006; 25 (12): 1603-1605. doi: 10.7863/jum.2006.25.12.1603
  • 8. Sureda D, Quiroga S, Arnal C, Boronat M, Andreu J et al. Juvenile rheumatoid arthritis of the knee: evaluation with US. Radiology 1994; 190 (2): 403-406. doi: 10.1148/radiology.190.2.8284388
  • 9. Nemec U, Nemec SF, Weber M, Brugger PC, Kasprian G et al. Human long bone development in vivo: analysis of the distal femoral epimetaphysis on MR images of fetuses. Radiology 2013; 267 (2): 570-580. doi: 10.1148/radiol.13112441
  • 10. Pazzaglia UE, Beluffi G, Benetti A, Bondioni MP, Zarattiniet G. A review of the actual knowledge of the processes governing growth and development of long bones. Fetal and Pediatric Pathology 2011; 30 (3): 199-208. doi: 10.3109/15513815.2010.524693
  • 11. Bayramoglu Z, Caliskan E, Karakas Z, Karaman S, Tugcu D et al. Diagnostic performances of superb microvascular imaging, shear wave elastography and shape index in pediatric lymph nodes categorization: a comparative study. The British Journal of Radiology 2018; 91 (1087): 20180129. doi: 10.1259/bjr.20180129
  • 12. Bayramoglu Z, Kandemirli SG, Akyol Sarı ZN, Kardelen AD, Poyrazoglu S et al. Superb microvascular imaging in the evaluation of pediatric Graves disease and hashimoto thyroiditis. Journal of Ultrasound in Medicine 2020; 39 (5): 901-909. doi: 10.1002/jum.15171
  • 13. Lee YS, Kim MJ, Han SW, Lee HS, Im YJ et al. Superb microvascular imaging for the detection of parenchymal perfusion in normal and undescended testes in young children. European Journal of Radiology 2016; 85 (3): 649-656. doi: 10.1016/j.ejrad.2015.12.023
  • 14. Zucker EJ, Lee EY, Restrepo R, Eisenberg RL. Hip disorders in children. American Journal of Roentgenology 2013; 201 (6): W776-796. doi: 10.2214/AJR.13.10623
  • 15. Windschall D, Pommerenke M, Haase R. Ultrasound assessment of the skeletal development of the proximal tibial, proximal femoral, and distal femoral epiphyses in premature and mature newborns. Ultrasound in Medicine & Biology 2016; 42 (2): 451-458. doi: 10.1016/j.ultrasmedbio.2015.10.020
  • 16. Mahony BS, Callen PW, Filly RA. The distal femoral epiphyseal ossification center in the assessment of third-trimester menstrual age: sonographic identification and measurement. Radiology 1985; 155 (4): 201-204. doi: 10.1148/radiology.155.1.3883417
  • 17. Birang S, Ameri AA, Najmi Z. Distal femoral epiphyses ossification center diameter and third trimester gestational age in Iranian population. Ginekologia Polska 2013; 84 (12): 1025-1029. doi: 10.17772/gp/1674
  • 18. Panghaal V, Janow G, Trinh A, Ilowite N, Levin TL. Normal epiphyseal cartilage measurements in the knee in children: an alternative sonographic approach. Journal of Ultrasound in Medicine 2012; 31 (1): 49-53. doi: 10.7863/jum.2012.31.1.49
  • 19. Paesano PL, Vigone MC, Siragusa V, Chiumello G, Maschio AD et al. Assessment of skeletal maturation in infants: comparison between two methods in hypothyroid patients. Pediatric Radiology 1998; 28 (8): 622-626. doi: 10.1007/s002470050432
  • 20. Spannow AH, Pfeiffer-Jensen M, Andersen NT, Herlin T, Stenbøg E. Ultrasonographic measurements of joint cartilage thickness in healthy children: age- and sex-related standard reference values. The Journal of Rheumatology 2010; 37 (12): 2595-2601. doi: 10.3899/jrheum.100101
  • 21. Jans LB, Jaremko JL, Ditchfield M, Verstraete KL. Evolution of femoral condylar ossification at MR imaging: frequency and patient age distribution. Radiology 2011; 258 (3): 880-888. doi: 10.1148/radiol.10101103
  • 22. Gebarski K, Hernandez RJ. Stage-I osteochondritis dissecans versus normal variants of ossification in the knee in children. Pediatric Radiology 2005; 35 (9): 880-886. doi: 10.1007/s00247-005-1507-6
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

What plays a role in the severity of atopic dermatitis in children?

Murat CANSEVER, Çiğdem ORUÇ

Translation and validation of a Turkish version of the Xerostomia Inventory XI in patients with primary Sjögren’s syndrome

Veli ÇOBANKARA, Hande ŞENOL, Aylin KESKİN, Sinem BOZCUK, Elif GÜR KABUL, Bilge BAŞAKCI ÇALIK

Cross-cultural adaptation, reliability, and validity of the Turkish version of the obesityspecific quality of life questionnaire: quality of life, obesity, and dietetics (QOLOD) rating scale

Mehmet Enes GÖKLER, Nimetcan Mehmet YAĞMA, Egemen ÜNAL, Salih MOLLAHALİLOĞLU

Risk factors related to the size and volume of femoral artery pseudoaneurysm after catheter angiography: a single-center study

İsa ÇAM, Ercüment ÇİFTÇİ, Özgür ÇAKIR, Ayşegül DURMAZ, Zeki TALAS, Duygu TEMİZ KARADAĞ, Mühip KANKO

Diagnostic value of procalcitonin and C reactive protein for infection and sepsis in elderly patients

Çiler ZİNCİRCİOĞLU, Hüseyin ÖZKARAKAŞ, Aykut SARITAŞ, Gürsel ERSAN, Kazım ROLLAS, Nimet ŞENOĞLU, Işıl Köse GÜLDOĞAN

Exercise capacity, muscle strength, dyspnea, physical activity, and quality of life in preoperative patients with lung cancer

Gülşah BARĞI, Ali ÇELİK, İsmail Cüneyt KURUL, , Ece BAYTOK, Zeliha ÇELİK, Meral BOŞNAK GÜÇLÜ

The utility of magnetic resonance angiography in children with nutcracker syndrome

0000-0002-9785-8067, Ayşegül CANSU, Dilara ATASOY, Ayşe Füsun BEKİRÇAVUŞOĞLU, Ali AHMETOĞLU

Mean platelet volume in familial Mediterranean fever related AA amyloidosis and comparison with common primary glomerular diseases

Rahmi YILMAZ, Emine Arzu AYHAN, Neriman Sıla KOÇ, Tolga YILDIRIM, Yunus ERDEM, Müge ÜZERK KİBAR, Berranur KÜTAHYA, Fatma İŞ, Mehmet ERDEVİR

Serum antiganglioside antibodies in patients with autoimmune limbic encephalitis

Elif ŞANLI, Vuslat YILMAZ, Birgül BAŞTAN TÜZÜN, Erdem TÜZÜN, Murat KÜRTÜNCÜ, Özlem SELÇUK, Cansu ELMAS TUNÇ, Şenol IŞILDAK, Ayşe Özlem ÇOKAR, Ayla ÇULHA OKTAR

Galectin-3: can it be a diagnostic tool for pneumonia in covid-19 patients?

Yasemin Coşkun YAVUZ, Ömer KARAŞAHİN, Mustafa KAHRAMAN, Can SEVİNÇ, Serkan CERRAH, Engin ŞEBİN, Hasan GÖĞEBAKAN, Ahmed Ramiz BAYKAN, Emine KARTAL BAYKAN